The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Fatty acid synthesis: a potential selective target for antineoplastic therapy
Open accessAbstract
OA-519 is a prognostic molecule found in tumor cells from breast cancer patients with markedly worsened prognosis. We purified OA-519 from human breast carcinoma cells, obtained its peptide sequence, and unambiguously identified it as fatty acid synthase through sequence homology and enzymology. Tumor fatty acid synthase is an approximately 270-kDa polypeptide which specifically abolished immunostaining of human breast cancers by anti-OA-519 antibodies. Tumor fatty acid synthase oxidized NADPH in a malonyl-CoA-dependent fashion and synthesized fatty acids composed of 80% palmitate, 10% myristate, and 10% stearate from acetyl-CoA, malonyl-CoA, and NADPH with a specific activity of 624 nmol of NADPH oxidized per min per mg. Tumor cell lines with elevated fatty acid synthase showed commensurate increases in incorporation of [U-14C]acetate into acylglycerols demonstrating that fatty acid synthase increases occur in the context of overall increases in endogenous fatty acid synthesis. Cerulenin inhibited acylglycerol synthesis in tumor cells and fibroblast controls in a dose-dependent fashion and also caused a growth inhibition which generally paralleled the level of endogenous fatty acid synthesis. Supraphysiologic levels of palmitate, 14 microM in dimethyl sulfoxide, significantly reversed the growth inhibition caused by cerulenin at concentrations of up to 5 micrograms/ml, indicating that cerulenin-mediated growth inhibition was due to fatty acid synthase inhibition.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Citations
Cites
Cleveland, D. W., Fischer, S. G., Kirschner, M. W., & Laemmli, U. K. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75212-0 · Cited by 5,556
Fatty acid synthase, a proficient multifunctional enzyme
Wakil, S. J. (1989) · Biochemistry · doi:10.1021/bi00437a001 · Cited by 823
A Practical Guide to Protein and Peptide Purification for Microsequencing
(1993) · Elsevier eBooks · doi:10.1016/c2009-0-03542-9 · Cited by 502
The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis
Ōmura, S. (1976) · Bacteriological Reviews · doi:10.1128/br.40.3.681-697.1976 · Cited by 403
Fletcher, J., Spector, A. A., & Ashbrook, J. D. (1971) · Biochemistry · doi:10.1021/bi00793a011 · Cited by 270
Stremmel, W., Strohmeyer, G. W., & Berk, P. D. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.3584 · Cited by 210
WEISS, L., HOFFMANN, G. E., Schreiber, R., Andres, H. H., Fuchs, E., KÖRBER, E., & Kolb, H. J. (1986) · Biological Chemistry Hoppe-Seyler · doi:10.1515/bchm3.1986.367.2.905 · Cited by 190
Binding Site of Cerulenin in Fatty Acid Synthetase1
Funabashi, H., Kawaguchi, A., Tomoda, H., Ōmura, S., Okuda, S., & Iwasaki, S. (1989) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a122739 · Cited by 179
Effects of free fatty acids on the growth of normal and neoplastic rat mammary epithelial cells.
Wicha, M. S., Liotta, L. A., & Kidwell, W. R. (1979) · PubMed · Cited by 169
Molecular cloning and sequencing of cDNAs encoding the entire rat fatty acid synthase.
Amy, C. M., Witkowski, A., Naggert, J. Κ., Williams, B., Randhawa, Z. I., & Smith, S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.9.3114 · Cited by 161
Cited by
Sorted by citations
Items 601–700 of 718
PKCβII–ACSL4 Axis Triggers Ferroptosis and Its Potential Implication in Ferroptosis-Related Diseases
Guo, Y.-Q., Zhang, H., Deng, R., & Zhu, X. (2023) · Springer eBooks · doi:10.1007/978-3-031-39171-2_20 · Cited by 1
Borús, D. L., Zadra, G., Minsky, D. M., Costa, M. L., Córsico, B., Storch, J., & Scaglia, N. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2025.159661 · Cited by 2
Karnan, S., Ota, A., Hasan, M. N., Murakami, H., Rahman, M. L., Wahiduzzaman, M., Shihan, M. T. A., Jahan, N., Vu, L. Q., Hanamura, I., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08481-y · Cited by 3
Hayashi, S., Ogawa, Y., Wakabayashi, N., Tokuyama, K., Oku, M., Yamamoto, T., Kato, S., Nusrat, A., & Kadowaki, M. (2026) · The FASEB Journal · doi:10.1096/fj.202504287r · Cited by 1
Huang, Y., Xu, Q., Zheng, L., Zheng, H., Chen, H., Li, Y., & Ma, S. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1846176 · Cited by 1
Transcriptional Regulation of Lipogenesis as a Therapeutic Target for Cancer Treatment
Wang, C., Ji, J., Tian, L., & Pestell, R. G. (2013) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-1-4614-8039-6_10 · Cited by 1
Regulation of Cancer Cell Metabolism by Hypoxia
Pulkoski‐Gross, A., Evensen, N. A., & Cao, J. P. (2014) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-1-4614-9545-1_4 · Cited by 1
Single-Particle Electron Microscopy of Animal Fatty Acid Synthase
Brignole, E. J., & Asturias, F. J. (2010) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(10)83009-5 · Cited by 1
Transepithelial transport of Cerulenin across Caco-2 cell monolayers
Fu, D., Liu, Z., Liu, J.-S., Luo, Y., Shu, Y., Huang, S.-H., & Han, Z. (2009) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/bf03191153 · Cited by 1
Xu, S., Spencer, C. M., & Munger, J. C. (2015) · Journal of Virology · doi:10.1128/jvi.03671-14 · Cited by 1
Koltai, T., Reshkin, S. J., Baltazar, F., & Fliegel, L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-90528-2.00012-6 · Cited by 2
Эрнста, И. И. Б. В. Ж. —. Ф. Ф. Ф. Ж. —. В. И. А. Л. К., & КОВАЛЬЧУК, С. Н. (2021) · Sel skokhozyaistvennaya Biologiya · doi:10.15389/agrobiology.2021.6.1049rus · Cited by 1
Wagner, S., Ewald, C., Freitag, D., Herrmann, K., Koch, A., Bauer, J., Vogl, T. J., Kemmling, A., & Gufler, H. (2024) · Cancers · doi:10.3390/cancers16081591 · Cited by 1
Glucocorticoid Regulation of Fatty Acid Synthase in Fetal Lung
Rooney, S. A. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-014-8_5 · Cited by 1
Translational Bioinformatics and Drug Discovery
Gupta, P. P. (2017) · Translational medicine research · doi:10.1007/978-94-024-1045-7_2 · Cited by 1
Koltai, T., Reshkin, S. J., & Harguindey, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819059-3.00002-2 · Cited by 1
Groscolas, R., Oudart, H., Bougnoux, P., & Lhuillery, C. (1995) · Nutrition and Cancer · doi:10.1080/01635589509514395 · Cited by 1
Mackay, E. M. (2015) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/26165 · Cited by 1
Gullberg, R. C., Chotiwan, N., Islam, M. N., Clair, L. A. S., Lian, E., Edwards, T. J., Khadka, S., Teng, C., Graham, B., Krieger, K. D., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.21.481365 · Cited by 1
Data from Anastrozole Regulates Fatty Acid Synthase in Breast Cancer
Cairns, J., Ingle, J. N., Kalari, K. R., Goetz, M. P., Weinshilboum, R. M., Gao, H., Li, H., Bari, M. G., & Wang, L. (2023) · doi:10.1158/1535-7163.c.6543547 · Cited by 1
Karnan, S., Ota, A., Hasan, M. N., Murakami, H., Rahman, M. L., Wahiduzzaman, M., Shihan, M. T. A., Jahan, N., Vu, L. Q., Hanamura, I., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.14.603191 · Cited by 1
Defined media reveals the essential role of lipid scavenging to support cancer cell proliferationPreprint
Newsom, O. J., & Sullivan, L. B. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.12.637975 · Cited by 1
Progestin-Regulated Genes and Breast Cancer Risk: Good or Bad?
Rochefort, H., Sahla, M. E., & Chalbos, D. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-387-23761-5_5 · Cited by 1
Mitochondria and cellular energy metabolism in platinum chemotherapy
Hernlund, E. (2009) · Figshare · Cited by 1
NMR-Based metabolomic studies of breast cancer
Yabsley, W. (2013) · UPT. Syiah Kuala University Library (Syiah Kuala University)
Fatty Acid Synthase, a Novel Target for the Treatment of Drug Resistant Breast Cancers
Liu, H. (2009) · IUScholarWorks (Indiana University) · doi:10.7912/c2/287
Emerging Therapies for Esophageal Cancer
Orita, H., Brock, M. V., & Sato, K. (2012) · InTech eBooks · doi:10.5772/30655
Chapter 4 Tumor markers for prostate cancer
Gao, X., & Honn, K. V. (1999) · Advances in oncobiology/Advances in oncobiology (Print) · doi:10.1016/s1569-254x(99)80005-3
McMahon, K. M. (2011) · Bradford Scholars (University of Bradford)
The Effects of Genistein to Expression of Fatty Acid Synthase in Breast Cancer Cells
Ra, Y.-M., Yim, J.-S., Song, K.-H., Ko, D.-G., Choi, I., Choi, W.-J., & Yoon, D.-S. (2007) · Journal of Breast Cancer · doi:10.4048/jbc.2007.10.2.127
The Central Nervous System in Metabolic Syndrome
Martins, L., Whittle, A. J., Nogueiras, R., Vidal‐Puig, A., Diéguez, C., & López, M. (2013) · Springer eBooks · doi:10.1007/978-3-319-01008-3_7
Rôle des régulateurs du cycle cellulaire dans le contrôle métabolique de la cellule cancéreuse
Lopez-Meija, I. C., Lagarrigue, S., & Lluis Fajas, A. (2014) · Obésité · doi:10.1007/s11690-014-0424-y
The Role of Fatty Acid Synthase Over-expression in Human Breast Cancer
Hopperton, K. E. (2012) · TSpace (University of Toronto)
Hill, C. U. F. K. (2015) · Leicester Research Archive (University of Leicester)
CONTROL TRANSCRIPCIONAL I AL·LOSTÈRIC DEL GEN CARNITINA PALMITOÏLTRANSFERASA 1B (CPT1B)
de Farmàcia, F., de Bioquímica, D., & Molecular, I. B. (2006)
Trends in the Research and Applications of Fatty Acid Synthase Inhibitors
Xu, R. (2010) · The Chinese Journal of Modern Applied Pharmacy
Yasuda, S., & Igoshi, K. (2013) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-766-0.046
Role of Amylase in Ovarian Cancer
Mohamed, M. (2017) · Digital Commons - University of South Florida (University of South Florida)
Zoubi, M. S. A., Chipitsyna, G. I., Sarosiek, K., Kang, C. Y., Yeo, C. J., & Arafat, H. A. (2013) · Gastroenterology · doi:10.1016/s0016-5085(13)63978-5
Wang, C. J. (2018) · IUScholarWorks (Indiana University) · doi:10.7912/c2/332
Gangl, M. R. (2016) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
Alfhili, M. A. (2019) · The Scholarship East Carolina University's Institutional Repository (East Carolina University)
Molecular Aspects of Cancer Cell Metabolism: Altered Glycolysis and Lipid Metabolism
Patel, S. K., Verma, D., & Garg, N. (2020) · Springer eBooks · doi:10.1007/978-981-15-1991-8_3
Lipidic profiling of human breast cancer plasma samples using hplc-esi-qtof
Aroca, J. A. (2016) · instname:Universidad de los Andes
Ji, F., Yu, S., Wu, Y., Lv, J., Zhang, P., Li, X., Jiang, C., Zhang, R., Song, L., Chen, Y., et al. (2019) · doi:10.21203/rs.2.18626/v1
DEVELOPMENT OF TOOLS FOR ATOM-LEVEL INTERPRETATION OF STABLE ISOTOPE-RESOLVED METABOLOMICS DATASETS
Jin, H. (2021) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2021.303
Kaaks, R. (2005) · Defense Technical Information Center (DTIC)
Serrat, G. O. (2012) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Kovalchuk, S. N. (2021) · Sel skokhozyaistvennaya Biologiya · doi:10.15389/agrobiology.2021.6.1049eng
Prasanth, S., Arun, G., Haridas, M., & Abdulhameed, S. (2020) · doi:10.22541/au.158636279.91157439
Escribá, P. V. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.04.023
Yasuda, S., & Igoshi, K. (2013) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-766-0_46
Diseases & Disorders | Fatty Acid Metabolism and Cancer
Kuhajda, F. P. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-819460-7.00563-6
Self-citationSerum Fatty Acid Synthase Level in Patients with Prostate Cancer and Benign Prostatic Hyperplasia
Farooq, Y. (2020) · Indian Journal of Forensic Medicine & Toxicology · doi:10.37506/ijfmt.v14i1.118
Proteomic Dynamics of Breast Cancers Identifies Potential Therapeutic Protein TargetsPreprint
Sun, R., Zhu, Y., Sayad, A., Ge, W., Luna, A., Liang, S., Segura, L. T., Rajapakse, V. N., Chen-huan, Y., Zhang, H., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.03.494776
An Integrative Pan-Cancer Analysis of FASN in Human TumorsPreprint
谭, 明., lin, X., chen, H., Ye, W., Yi, J., & Su, J. (2022) · Research Square · doi:10.21203/rs.3.rs-1698683/v1
The role of fatty acids metabolism on cancer progression and therapeutics development
Moreira-Barbosa, C., Matos, A., Fernandes, R., Mendes-Ferreira, M., Rodrigues, R. C., Cruz, T., Costa, Â. M., Cardoso, A. P., Ghilardi, C., Oliveira, M. J., et al. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824043-4.00007-5
Metabolismo lipídico en un modelo experimental de cáncer de pulmón: rol de FABP5
Garcia, K. A. (2022) · El Servicio de Difusión de la Creación Intelectual (National University of La Plata) · doi:10.35537/10915/143241
Pei, Z., Sun, P., Huang, P., Lal, B., Laterra, J., & Watkins, P. A. (2023) · doi:10.1158/0008-5472.c.6499716.v1
Fritz, V., Benfodda, Z., Rodier, G., Henriquet, C., Iborra, F., Avancès, C., Allory, Y., TAILLE, A. D. L., Culine, S., Blancou, H., et al. (2023) · doi:10.1158/1535-7163.c.6531641
Fritz, V., Benfodda, Z., Rodier, G., Henriquet, C., Iborra, F., Avancès, C., Allory, Y., TAILLE, A. D. L., Culine, S., Blancou, H., et al. (2023) · doi:10.1158/1535-7163.c.6531641.v1
Data from Lipoprotein Lipase Links Dietary Fat to Solid Tumor Cell Proliferation
Kuemmerle, N. B., Rysman, E., Lombardo, P. S., Flanagan, A. J., Lipe, B. C., Wells, W. A., Pettus, J. R., Froehlich, H. M., Memoli, V. A., Morganelli, P. M., et al. (2023) · doi:10.1158/1535-7163.c.6535440
R�os, S., Santos, C. R., Moco, S., Baenke, F., Kelly, G. P., Howell, M., Zamboni, N., & Schulze, A. (2023) · doi:10.1158/2159-8290.22528403
R�os, S., Santos, C. R., Moco, S., Baenke, F., Kelly, G. P., Howell, M., Zamboni, N., & Schulze, A. (2023) · doi:10.1158/2159-8290.22528403.v1
Data from Anastrozole Regulates Fatty Acid Synthase in Breast Cancer
Cairns, J., Ingle, J. N., Kalari, K. R., Goetz, M. P., Weinshilboum, R. M., Gao, H., Li, H., Bari, M. G., & Wang, L. (2023) · doi:10.1158/1535-7163.c.6543547.v1
Alsiary, R., Katouah, H. A., Al-Amodi, H. S. A. B., & Al-Toub, M. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815080384123010007
Crispino, P., Ciarambino, T., & Giordano, M. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45060299
Development of a fatty acid metabolism-related genes predictive model in colon cancer patientsPreprint
Wang, X., Chen, M., Bai, S., Li, R., Lan, N., Li, W., Wu, F., Liu, W., Hu, F., Zhang, X., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3085478/v1
Mendelian randomization analysis of the causal association between metabolites and skin cancer
Wang, D., Tan, M., Iv, N., Ung, R., Lim, G., Say, V., Phal, S., & Nov, P. (2025) · Dermatology Reports · doi:10.4081/dr.2025.10159
Huang, Y.-Y., Chang, Y.-L., Chen, Y., Chiang, W.-Y., Chiang, A.-T., Hsu, P., & Teng, S. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110914
Additional file 4 of Lipid metabolic features of T cells in the Tumor Microenvironment
Lou, W., Chaoju, 宫. G., Ye, Z., Hu, Y., Zhu, M., Fang, Z., & Xu, H. (2022) · Figshare · doi:10.6084/m9.figshare.21291866
Additional file 2 of Lipid metabolic features of T cells in the Tumor Microenvironment
Lou, W., Chaoju, 宫. G., Ye, Z., Hu, Y., Zhu, M., Fang, Z., & Xu, H. (2022) · Figshare · doi:10.6084/m9.figshare.21291860
Zhengdong, A., Xiaoying, X., Shuhui, F., Rui, L., Zehui, T., Guanbin, S., Li, Y., Xi, T., & Wanqian, L. (2024) · Figshare · doi:10.6084/m9.figshare.26703298
Zhengdong, A., Xiaoying, X., Shuhui, F., Rui, L., Zehui, T., Guanbin, S., Li, Y., Xi, T., & Wanqian, L. (2024) · Figshare · doi:10.6084/m9.figshare.25560909
Additional file 3 of Lipid metabolic features of T cells in the Tumor Microenvironment
Lou, W., Chaoju, 宫. G., Ye, Z., Hu, Y., Zhu, M., Fang, Z., & Xu, H. (2022) · Figshare · doi:10.6084/m9.figshare.21291863
Zhengdong, A., Xiaoying, X., Shuhui, F., Rui, L., Zehui, T., Guanbin, S., Li, Y., Xi, T., & Wanqian, L. (2024) · Figshare · doi:10.6084/m9.figshare.26703295
Zhengdong, A., Xiaoying, X., Shuhui, F., Rui, L., Zehui, T., Guanbin, S., Li, Y., Xi, T., & Wanqian, L. (2024) · Figshare · doi:10.6084/m9.figshare.25560882
Additional file 1 of Lipid metabolic features of T cells in the Tumor Microenvironment
Lou, W., Chaoju, 宫. G., Ye, Z., Hu, Y., Zhu, M., Fang, Z., & Xu, H. (2022) · Figshare · doi:10.6084/m9.figshare.21291857
Zhengdong, A., Xiaoying, X., Shuhui, F., Rui, L., Zehui, T., Guanbin, S., Li, Y., Xi, T., & Wanqian, L. (2024) · Figshare · doi:10.6084/m9.figshare.26703292
Characterisation of potential vaccine targets in Haemonchus contortus
Bouchet, C., Knight, J. S., Cleland, S. B., Grant, W. N., & Umair, S. (2026) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2026.111737
Minville-Walz, M. (2010) · theses.fr (ABES) · doi:10.70675/38d9ce8czc395z4debza0d9zb24a4fb63da0
Rôle de l'autophagie dans l'émergence des cellules souches cancéreuses : implication du métabolisme
El-Hout, M. (2019) · theses.fr (ABES) · doi:10.70675/881cf980z01caz4a56z8a81zdcebe1247536
EVT-701 : targeting electron transport chain complex I as therapeutic approach in cancer
Yolba, R. L. (2021) · theses.fr (ABES) · doi:10.70675/9cadea77z03ccz4a54zb381zf34a432615a5
Tan, H., Wang, L., Wang, L., Xie, S., Zhu, W., Zhu, W., & Tan, Q. (2026) · Aquaculture International · doi:10.1007/s10499-026-02575-2
Metadata
- Authors
- Kuhajda, F. P., Jenner, K., Wood, F. D., Hennigar, R. A., Jacobs, L. B., Dick, J. D., & Pasternack, G. R.
- Affiliations
- Johns Hopkins University (US)
- ORCID
- Hennigar, R A
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1994-07-05
- Volume
- 91
- Issue
- 14
- Pages
- 6379-6383
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC44205
- OpenAlex
- W2090846942
- Cited by
- 705
- References
- 26
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 12 · 2023: 32 · 2022: 33 · 2021: 30 · 2020: 19 · 2019: 29 · 2018: 18 · 2017: 31 · 2016: 39 · 2015: 28 · 2014: 38 · 2013: 33 · 2012: 36
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Keywords
- fatty acid synthase, breast cancer, cerulenin, antineoplastic therapy, fatty acid synthesis, palmitate, NADPH oxidation, malonyl-CoA, tumor growth inhibition
- MeSH terms
- Acetates, Antibodies, Antigens, Neoplasm, Blood Proteins, Breast Neoplasms, Carbon Radioisotopes, Cell Division, Cell Line, Cerulenin, Fatty Acids, Female, Haptoglobins, Humans, Immunohistochemistry, Kinetics, Malonyl Coenzyme A, Palmitic Acids, Prognosis, Tumor Cells, Cultured, Biomarkers, Tumor, Drug Design, Palmitic Acid, Fatty Acid Synthases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
