The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the J kappa recombination signal binding protein.
Open accessAbstract
Epstein-Barr virus nuclear antigen 2 (EBNA-2) plays an essential role in primary B-lymphocyte growth transformation. EBNA-2 is an acidic transcriptional transactivator that is brought to virus and cell EBNA-2 response elements by interaction with a factor that recognizes the double-stranded sequence MNYYGTGGGAA, where M is A or C, N is any nucleotide, and Y is a pyrimidine. A 63-kDa protein that recognizes this DNA sequence has now been purified by S-Sepharose and oligonucleotide affinity chromatography. p63 peptide sequence is identical to the predicted amino acid sequence for the human J kappa immunoglobulin recombination signal binding protein. Purified or recombinant in vitro-translated J kappa binds to the MNYYGTGGGAA EBNA-2 response element sequence and interacts with EBNA-2. Surprisingly, J kappa does not bind to the J kappa 1 heptamer recombination signal sequence (CACTGTG), and its prior identification as a heptamer binding protein was most likely due to the addition of a BamHI restriction site to the native heptamer creating a near EBNA-2 response element consensus (CACTGTGGGAT).
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Metadata
- Authors
- Grossman, S. R., Johannsen, E., Tong, X., Yalamanchili, R., & Kieff, E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-08-02
- Volume
- 91
- Issue
- 16
- Pages
- 7568-7572
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1970269101
- Cited by
- 345
- References
- 25
- FWCI
- 8.09
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the J kappa recombination signal binding protein. https://app.cochat.ai/papers/10.1073/pnas.91.16.7568
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- Grossman, S. R., Johannsen, E., Tong, X., Yalamanchili, R., & Kieff, E. (1994). The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the J kappa recombination signal binding protein. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.16.7568
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