The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy.
Open accessAbstract
Transgenic mice were generated by using the alpha-myosin heavy chain promoter coupled to the coding sequence of a constitutively active mutant alpha 1B-adrenergic receptor (AR). These transgenic animals demonstrated cardiac-specific expression of this alpha 1-AR with resultant activation of phospholipase C as shown by increased myocardial diacylglycerol content. A phenotype consistent with cardiac hypertrophy developed in adult transgenic mice with increased heart/body weight ratios, myocyte cross-sectional areas, and ventricular atrial natriuretic factor mRNA levels relative to nontransgenic controls. These transgenic animals may provide insight into the biochemical triggers that induce hypertrophy in cardiac disease and serve as a convenient experimental model for studies of this condition.
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Cites
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751
Simpson, P. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111023 · Cited by 618
Cited by
Signaling Pathways for Cardiac Hypertrophy and Failure
Hunter, J. J., & Chien, K. R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199910213411706 · Cited by 869
Progressive hypertrophy and heart failure in β 1 -adrenergic receptor transgenic mice
Engelhardt, S., Hein, L., Wiesmann, F., & Lohse, M. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.7059 · Cited by 785
Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor
Koch, W. J., Rockman, H. A., Samama, P., Hamilton, R., Bond, R. A., Milano, C. A., & Lefkowitz, R. J. (1995) · Science · doi:10.1126/science.7761854 · Cited by 719
Self-citationAdrenergic and Muscarinic Receptors in the Human Heart
Brodde, O.-E., & Michel, M. C. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01425-x · Cited by 673
Transgenic Gαq overexpression induces cardiac contractile failure in mice
D’Angelo, D. D., Sakata, Y., Lorenz, J. N., Boivin, G. P., Walsh, R. A., Liggett, S. B., & Dorn, G. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.8121 · Cited by 629
Metadata
- Authors
- Milano, C. A., Dolber, P. C., Rockman, H. A., Bond, R. A., Venable, M. E., Allen, L. F., & Lefkowitz, R. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-10-11
- Volume
- 91
- Issue
- 21
- Pages
- 10109-10113
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2082201094
- Cited by
- 371
- References
- 2
- FWCI
- 15.28
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Milano, C. A., Dolber, P. C., Rockman, H. A., Bond, R. A., Venable, M. E., Allen, L. F., & Lefkowitz, R. J. (1994). Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.21.10109
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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