Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha-1 adrenergic response

Simpson, P

doi:10.1172/jci111023

Cited by 618Receptor Mechanisms and SignalingCardiac Fibrosis and RemodelingCardiomyopathy and Myosin Studies

Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha-1 adrenergic response

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Simpson, P·1983·Journal of Clinical Investigation

DOI 10.1172/jci111023PMC PMC1129233

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Abstract

We have shown recently that norepinephrine stimulates muscle cell hypertrophy in primary cultures from the neonatal rat ventricle and that this stimulation is not blocked by the beta adrenergic antagonist propranolol. The present study was done to define the adrenergic specificity of the myocyte hypertrophic response to norepinephrine. 90% pure, single-cell cultures of nongrowing myocytes were maintained in serum-free medium 199 with transferin and insulin. Myocyte size was quantitated 48 h after addition of adrenergic agents, by measuring cell volume, cell surface area, and cell protein. L-norepinephrine increased myocyte size to a maximum 150% of control; half-maximum effect was obtained at a concentration of 0.2 microM. This increase in cell size was inhibited by the nonselective alpha adrenergic antagonist phentolamine and by the alpha 1 adrenergic antagonists prazosin and terazosin; it was not inhibited by propranolol or by the alpha 2 adrenergic antagonist yohimbine. The beta adrenergic agonist isoproterenol did not increase cell size. Thus, norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response.

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Catecholamines have trophic properties on cardiac myocytes and in the intact animal heart.
“In support of this, catecholamines have been shown experimentally to have trophic properties on cardiac myocytes (35)and in the intact animal heart (36).”
From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [35]

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Stimulation of hypertrophy of cultured neonatal rat heart cells through an alpha 1-adrenergic receptor and induction of beating through an alpha 1- and beta 1-adrenergic receptor interaction. Evidence for independent regulation of growth and beating.
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The mechanism of norepinephrine inducing myocardial hypertrophy
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Authors: Simpson, P.
Affiliations: San Francisco VA Medical Center (US)
Corresponding author: Simpson, P
ORCID: Simpson, P
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1983-08-01
Volume: 72
Issue: 2
Pages: 732-738
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci111023
PMC: PMC1129233
OpenAlex: W2110889457
Cited by: 618
References: 20
Citations by year: 2026: 4 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 10 · 2012: 6
FWCI: 3.65
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: University of California, San Francisco
National Heart, Lung, and Blood Institute (R01HL031113)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
Keywords: norepinephrine, cardiac hypertrophy, alpha1-adrenoceptors, alpha-blockers, phentolamine, prazosin, terazosin, yohimbine, isoproterenol, propranolol
MeSH terms: Adrenergic alpha-Antagonists, Animals, Cardiomegaly, Isoproterenol, Myocardium, Norepinephrine, Phentolamine, Prazosin, Propranolol, Receptors, Adrenergic, Receptors, Adrenergic, alpha, Rats

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Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha-1 adrenergic response

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