The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease.
Open accessAbstract
The most frequent DNA adduct made by the anticancer drug cisplatin, the 1,2-intrastrand d(GpG) cross-link, as well as the minor 1,3-intrastrand d(GpTpG) adduct, were both repaired by an in vitro human excision repair system. Fragments of 27-29 nt containing the platinum damage were excised. The high mobility group (HMG)-domain proteins HMG1 and human mitochondrial transcription factor specifically inhibited repair of the 1,2-intrastrand cross-link by the human excision nuclease. These results suggest that the types and levels of HMG-domain proteins in a given tumor may influence the responsiveness of that cancer to cisplatin chemotherapy and they provide a rational basis for the synthesis of new platinum anticancer drug candidates.
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Cites
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Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins
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Specific Recognition of Cruciform DNA by Nuclear Protein HMG1
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Similarity of Human Mitochondrial Transcription Factor 1 to High Mobility Group Proteins
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Specific Binding of Chromosomal Protein HMG1 to DNA Damaged by the Anticancer Drug Cisplatin
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Self-citationStructural features of the HMG chromosomal proteins and their genes
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Self-citation
Cited by
Cellular processing of platinum anticancer drugs
Wang, D., & Lippard, S. J. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1691 · Cited by 3,801
Self-citationCisplatin: mode of cytotoxic action and molecular basis of resistance
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Mechanisms of resistance to cisplatin
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Metadata
- Authors
- Huang, J. C., Zamble, D. B., Reardon, J. T., Lippard, S. J., & Sancar, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-10-25
- Volume
- 91
- Issue
- 22
- Pages
- 10394-10398
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2022631460
- Cited by
- 347
- References
- 24
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease. https://app.cochat.ai/papers/10.1073/pnas.91.22.10394
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- Huang, J. C., Zamble, D. B., Reardon, J. T., Lippard, S. J., & Sancar, A. (1994). HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.22.10394
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
