The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Similarity of Human Mitochondrial Transcription Factor 1 to High Mobility Group Proteins
Abstract
Human mitochondrial transcription factor 1 (mtTF1) has been sequenced and is a nucleus-encoded DNA binding protein of 204 amino acids (24,400 daltons). Expression of human mtTF1 in bacteria yields a protein with correct physical properties and the ability to activate mitochondrial DNA promoters. Analysis of the protein's sequence reveals no similarities to any other DNA binding proteins except for the existence of two domains that are characteristic of high mobility group (HMG) proteins. Human mtTF1 is most closely related to a DNA binding HMG-box region in hUBF, a human protein known to be important for transcription by RNA polymerase I.
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Cites
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Cited by
Metabolic control through the PGC-1 family of transcription coactivators
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“…targets of PGC-1α (Wu et al., 1999) and are able to stimulate the expression of mitochondrial transcription factor A (Tfam), a mitochondrial matrix protein essential for the replication and transcription of mitochondrial DNA (Clayton, 1991; Parisi and Clayton, 1991; Virbasius and Scarpulla, 1994).”
BackgroundThe mitochondrial genome: structure, transcription, translation and replication
Taanman, J.-W. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00161-3 · Cited by 1,635
Transcriptional paradigms in mammalian mitochondrial biogenesis and function
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Mitochondrial transcription factor A is necessary for mtDNA maintance and embryogenesis in mice
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Self-citationMitochondrial DNA in innate immune responses and inflammatory pathology
West, A. P., & Shadel, G. S. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.21 · Cited by 1,115
Metadata
- Authors
- Parisi, M. A., & Clayton, D. A.
- Venue
- Science
- Published
- 1991-05-17
- Volume
- 252
- Issue
- 5008
- Pages
- 965-969
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2067322059
- Cited by
- 543
- References
- 38
- FWCI
- 10.02
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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