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Free radical adducts induce alterations in DNAcytosine methylation.
Open accessAbstract
Methylation of cytosines in DNA is important for the regulation of expression of many genes. During carcinogenesis, normal patterns of gene methylation can be altered. Oxygen radical injury, shown to damage DNA in a variety of ways associated with cancer development and other conditions, has been suggested to affect DNA methylation, but a mechanism has not been demonstrated. Using oligonucleotides containing the common oxygen radical adduct 8-hydroxyguanine to replace guanine, we found that the enzymatic methylation of adjacent cytosines is profoundly altered. Furthermore, there is a high degree of positional specificity with respect to this effect. Thus, free radical injury may explain some of the altered methylation observed during carcinogenesis.
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Cited by
WISEMAN, H., & HALLIWELL, B. (1996) · Biochemical Journal · doi:10.1042/bj3130017 · Cited by 2,345
Cuzzocrea, S., Riley, D. P., Caputi, A. P., & Salvemini, D. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01484-4 · Cited by 1,087
Oxidative stress response and Nrf2 signaling in aging
Zhang, H., Davies, K. J. A., & Forman, H. J. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.036 · Cited by 804
Oxidative stress, DNA methylation and carcinogenesis
Franco, R., Schoneveld, O., Georgakilas, A. G., & Panayiotidis, M. I. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.02.026 · Cited by 603
Epigenetics, oxidative stress, and Alzheimer disease
Zawia, N. H., Lahiri, D. K., & Cardozo-Pelaez, F. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.02.006 · Cited by 337
Metadata
- Authors
- Weitzman, S. A., Turk, P. W., Milkowski, D. H., & Kozlowski, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-02-15
- Volume
- 91
- Issue
- 4
- Pages
- 1261-1264
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2042369211
- Cited by
- 299
- References
- 0
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- green
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- Weitzman, S. A., Turk, P. W., Milkowski, D. H., & Kozlowski, K. (1994). Free radical adducts induce alterations in DNAcytosine methylation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.4.1261
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