The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Radial glial cell transformation to astrocytes is bidirectional: regulation by a diffusible factor in embryonic forebrain.
Open accessAbstract
During development of mammalian cerebral cortex, two classes of glial cells are thought to underlie the establishment of cell patterning. In the embryonic period, migration of young neurons is supported by a system of radial glial cells spanning the thickness of the cortical wall. In the neonatal period, neuronal function is assisted by the physiological support of a second class of astroglial cell, the astrocyte. Here, we show that expression of embryonic radial glial identity requires extrinsic soluble signals present in embryonic forebrain. Moreover, astrocytes reexpress features of radial glia in vitro in the presence of the embryonic cortical signals and in vivo after transplantation into embryonic neocortex. These findings suggest that the transformation of radial glia cells into astrocytes is regulated by availability of inducing signals rather than by changes in cell potential.
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Cites
Mode of cell migration to the superficial layers of fetal monkey neocortex
Rakic, P. (1972) · Journal of Comparative Neurology · doi:10.1002/cne.901450105 · Cited by 2,170
Autoradiographic Study of Cell Migration during Histogenesis of Cerebral Cortex in the Mouse
ANGEVINE, J. B., & SIDMAN, R. L. (1961) · Nature · doi:10.1038/192766b0 · Cited by 1,530
Caviness, V. S., & Sidman, R. L. (1973) · Journal of Comparative Neurology · doi:10.1002/cne.901480202 · Cited by 413
Cited by
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage
Malatesta, P., Hartfuss, E., & Götz, M. (2000) · Development · doi:10.1242/dev.127.24.5253 · Cited by 1,157
Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain
Laywell, E. D., Rakic, P., Kukekov, V. G., Holland, E. C., & Steindler, D. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.250471697 · Cited by 721
Gal, J. S., Morozov, Y. M., Ayoub, A. E., Chatterjee, M., Rakic, P., & Haydar, T. F. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4499-05.2006 · Cited by 342
Reelin signaling directly affects radial glia morphology and biochemical maturation
Hartfuss, E., Förster, E., Bock, H. H., Hack, M. A., Leprince, P., Luque, J. M., Herz, J., Frotscher, M., & Götz, M. (2003) · Development · doi:10.1242/dev.00654 · Cited by 237
Metadata
- Authors
- Hunter, K. E., & Hatten, M. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-03-14
- Volume
- 92
- Issue
- 6
- Pages
- 2061-2065
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2070108346
- Cited by
- 167
- References
- 3
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hunter, K. E., & Hatten, M. E. (1995). Radial glial cell transformation to astrocytes is bidirectional: regulation by a diffusible factor in embryonic forebrain. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.6.2061
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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