CoChat
Sign Up
Cited by 413Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationFetal and Pediatric Neurological Disorders

Time of origin of corresponding cell classes in the cerebral cortex of normal and reeler mutant mice: An autoradiographic analysis

Caviness, V. S., Sidman, R. L.·1973·Journal of Comparative Neurology
DOI 10.1002/cne.901480202
Open this paper in CoChat — free account

Abstract

Reeler, a recessive mutation in mice, causes cytoarchitectonic abnormalities of the cerebral and cerebellar cortices. Although the relative positions of classes of cells in the cerebral cortex are markedly abnormal, the time of origin of cells in each class appears to be normal by autoradiographic criteria. In the retrohippocampal cortical structures and in the adjacent neocortex, the earliest generated cell class, the polymorphic, arises at the same embryonic time in normal and reeler littermates. Whereas these cells come to form the deepest stratum of the normal cortex, they lie in an immediately subpial position in the mutant, there being no cell‐sparse external plexiform (molecular) layer. A population of larger cells is generated next; these normally come to lie in more superficial layers but instead lie deep to the polymorphic cells in the mutant. Granule cells of the neocortex arise last, simultaneously in normal and reeler; they form the most superficial neocortical cell stratum in the normal, but lie at a more restricted level within the large cell zone in the mutant. These data indicate that the cytoarchitectonic anomaly in reeler is independent of the spatiotemporal program of cell generation. It appears likely that the reeler genetic locus governs embryonic events, as yet undefined, that direct the postmitotic migrating young neuron to class‐specific levels within the cortex.

Integrity signals

Registry

Crossref · 10.1002/cne.901480202

Cites

17 of 17 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The reeler mouse mutant has neurons generated normally but abnormally placed, resulting in disorganization of cortical laminar layers in the CNS.

    “The reeler is an autosomal recessive mouse mutant, in which neurons are generated normally but are abnormally placed, resulting in disorganization of cortical laminar layers in the CNS (7–12).”

    From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [11]

  • In the reeler mouse model, lamination of principal cells in cortex is inverted and the s.p. of the hippocampus is split in region CA1.

    “in the reeler mouse model, in which expression of reelin or associated proteins is disrupted, the lamination of PCs in cortex is inverted and the s.p. of the hippocampus is split in region CA1”

    From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [180]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Caviness, V. S., & Sidman, R. L.
Affiliations
Harvard University (US)
ORCID
Sidman, R. L.
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
1973-03-15
Volume
148
Issue
2
Pages
141-151
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.901480202
OpenAlex
W1994406909
Cited by
413
References
17
Citations by year
2025: 4 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 5 · 2018: 3 · 2017: 10 · 2016: 6 · 2015: 10 · 2014: 13 · 2013: 15 · 2012: 10
FWCI
3.77
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 11531 d)
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
Keywords
cerebral cortex, cell migration, cytoarchitecture, granule cells, cortical layers, neocortex, cerebellum, embryonic development
MeSH terms
Animals, Autoradiography, Cell Differentiation, Cerebral Cortex, Hippocampus, Movement Disorders, Neurons, Thymidine, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review