Cited by 633Cannabis and Cannabinoid ResearchMast cells and histamineInflammatory mediators and NSAID effects

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Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide

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Facci, L, Dal Toso, R, Romanello, S, Buriani, A, Skaper, S D, Leon, A·1995·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.92.8.3376PMC PMC42169

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Abstract

Mast cells are multifunctional bone marrow-derived cells found in mucosal and connective tissues and in the nervous system, where they play important roles in tissue inflammation and in neuroimmune interactions. Very little is known about endogenous molecules and mechanisms capable of modulating mast cell activation. Palmitoylethanolamide, found in peripheral tissues, has been proposed to behave as a local autacoid capable of downregulating mast cell activation and inflammation. A cognate N-acylamide, anandamide, the ethanolamide of arachidonic acid, occurs in brain and is a candidate endogenous agonist for the central cannabinoid receptor (CB1). As a second cannabinoid receptor (CB2) has been found in peripheral tissues, the possible presence of CB2 receptors on mast cells and their interaction with N-acylamides was investigated. Here we report that mast cells express both the gene and a functional CB2 receptor protein with negative regulatory effects on mast cell activation. Although both palmitoylethanolamide and anandamide bind to the CB2 receptor, only the former downmodulates mast cell activation in vitro. Further, the functional effect of palmitoylethanolamide, as well as that of the active cannabinoids, was efficiently antagonized by anandamide. The results suggest that (i) peripheral cannabinoid CB2 receptors control, upon agonist binding, mast cell activation and therefore inflammation; (ii) palmitoylethanolamide, unlike anandamide, behaves as an endogenous agonist for the CB2 receptor on mast cells; (iii) modulatory activities on mast cells exerted by the naturally occurring molecule strengthen a proposed autacoid local inflammation antagonism (ALIA) mechanism; and (iv) palmitoylethanolamide and its derivatives may provide antiinflammatory therapeutic strategies specifically targeted to mast cells ("ALIAmides").

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Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633
Molecular characterization of a peripheral receptor for cannabinoids
Munro, S., Thomas, K. L., & Abu-Shaar, M. (1993) · Nature · doi:10.1038/365061a0 · Cited by 5,092
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011
Determination and characterization of a cannabinoid receptor in rat brain
Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S., & Howlett, A. C. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09876-1 · Cited by 2,443
Inflammation. Basic principles and clinical correlates
(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90156-x · Cited by 2,388
Cannabinoid receptor localization in brain.
Herkenham, M., Lynn, A. B., Little, M. D., Johnson, M. R., Melvin, L. S., de Costa, B. R., & Rice, K. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1932 · Cited by 2,321
Manual of pharmacologic calculations with computer programs
(1988) · International Journal of Biochemistry · doi:10.1016/0020-711x(88)90084-5 · Cited by 1,458
Molecular cloning of a human cannabinoid receptor which is also expressed in testis
Gérard, C. M., Mollereau, C., Vassart, G., & Parmentier, M. (1991) · Biochemical Journal · doi:10.1042/bj2790129 · Cited by 698

Flagged first, then by citations

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Items 101–200 of 633

The N‐Acylethanolamine‐Hydrolyzing Acid Amidase (NAAA)
Tsuboi, K., Takezaki, N., & Ueda, N. (2007) · Chemistry & Biodiversity · doi:10.1002/cbdv.200790159 · Cited by 172
CB2 cannabinoid receptor mediation of antinociception
Ibrahim, M. M., Rude, M. L., Stagg, N. J., Mata, H. P., Lai, J. Y., Vanderah, T. W., Porreca, F., Buckley, N. E., Makriyannis, A., & Malan, P. T. (2006) · Pain · doi:10.1016/j.pain.2005.12.018 · Cited by 173
Neuroinflammation, Microglia and Mast Cells in the Pathophysiology of Neurocognitive Disorders: A Review
Skaper, S. D., Facci, L., & Giusti, P. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130224206 · Cited by 169
Self-citation
Influence of fatty acid ethanolamides and Δ9-tetrahydrocannabinol on cytokine and arachidonate release by mononuclear cells
Berdyshev, E. V., Boichot, E., Germain, N., Allain, N., Anger, J.-P., & Lagente, V. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01007-8 · Cited by 168
Postsynaptic localization of CB2 cannabinoid receptors in the rat hippocampus
Brusco, A., Tagliaferro, P. A., Saez, T. M. M., & Onaivi, E. S. (2008) · Synapse · doi:10.1002/syn.20569 · Cited by 166
Presence of the cannabinoid receptors, CB1 and CB2, in human omental and subcutaneous adipocytes
Roche, R., Hoareau, L., Bès-Houtmann, S., Gonthier, M., Laborde, C., Baron, J.-F., Haffaf, Y., Césari, M., & Festy, F. (2006) · Histochemistry and Cell Biology · doi:10.1007/s00418-005-0127-4 · Cited by 174
Quantification of Bioactive Acylethanolamides in Rat Plasma by Electrospray Mass Spectrometry
Giuffrida, A., de Fonseca, F. R., & Piomelli, D. (2000) · Analytical Biochemistry · doi:10.1006/abio.2000.4509 · Cited by 163
Cannabinoid receptors: nomenclature and pharmacological principles
Console‐Bram, L., Marcu, J. P., & Abood, M. E. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.02.009 · Cited by 169
The expanding field of cannabimimetic and related lipid mediators
Bradshaw, H. B., & Walker, J. M. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706093 · Cited by 164
Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain
Elmes, S. J. R., Jhaveri, M. D., Smart, D., Kendall, D. A., & Chapman, V. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03690.x · Cited by 160
Spinal and peripheral mechanisms of cannabinoid antinociception: behavioral, neurophysiological and neuroanatomical perspectives
Hohmann, A. G. (2002) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(02)00154-8 · Cited by 161
Endocannabinoid signalling in innate and adaptive immunity
Chiurchiù, V., Battistini, L., & Maccarrone, M. (2015) · Immunology · doi:10.1111/imm.12441 · Cited by 158
Endogenous Cannabinoid Signaling
Piomelli, D., Beltramo, M., Giuffrida, A., & Stella, N. (1998) · Neurobiology of Disease · doi:10.1006/nbdi.1998.0221 · Cited by 160
Hematopoietic cells expressing the peripheral cannabinoid receptor migrate in response to the endocannabinoid 2-arachidonoylglycerol
Alberich-Jordà, M., Verbakel, S. E., Valk, P. J. M., Vankan, Y., Maccarrone, M., Finazzi-Agrò, A., Löwenberg, B., & Delwel, R. (2002) · Blood · doi:10.1182/blood.v99.8.2786 · Cited by 161
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Marzo, V. D., Bisogno, T., Melck, D. J., Ross, R. A., Brockie, H. C., Stevenson, L., Pertwee, R. G., & PETROCELLIS, L. D. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01175-2 · Cited by 157
Pathways and mechanisms of N-acylethanolamine biosynthesis: can anandamide be generated selectively?
Schmid, H. H. O. (2000) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(00)00188-2 · Cited by 155
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Maccarrone, M., Valensise, H. C. C., Bari, M., Lazzarin, N., Romaninï, C., & Finazzi‐Agrò, A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7183 · Cited by 152
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Bifulco, M., Laezza, C., Valenti, M., Ligresti, A., Portella, G., & Marzo, V. D. (2004) · The FASEB Journal · doi:10.1096/fj.04-1754fje · Cited by 154
Carrier-Mediated Uptake of the Endogenous Cannabinoid Anandamide in RBL-2H3 Cells
Rakhshan, F., Day, T. A., Blakely, R., & Barker, E. L. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35376-5 · Cited by 149
Palmitoylethanolamide in CNS health and disease
Raso, G. M., Russo, R., Calignano, A., & Meli, R. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.05.006 · Cited by 153
Comparative Characterization of a Wild Type and Transmembrane Domain-Deleted Fatty Acid Amide Hydrolase: Identification of the Transmembrane Domain as a Site for Oligomerization
Patricelli, M. P., Lashuel, H. A., Giang, D. K., Kelly, J. W., & Cravatt, B. F. (1998) · Biochemistry · doi:10.1021/bi981733n · Cited by 147
(—)-Δ9-Tetrahydrocannabinol Antagonizes the Peripheral Cannabinoid Receptor-mediated Inhibition of Adenylyl Cyclase
Bayewitch, M. L., Rhee, M. H., Avidor‐Reiss, T., Breuer, A., Mechoulam, R., & Vogel, Z. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.17.9902 · Cited by 149
Palmitoylethanolamide: A Natural Compound for Health Management
Clayton, P., Hill, M., Bogoda, N. O., Subah, S., & Venkatesh, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105305 · Cited by 153
Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain
Jhaveri, M. D., Richardson, D. S., & Chapman, V. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707433 · Cited by 147
Anticonvulsant Activity of N‐Palmitoylethanolamide, a Putative Endocannabinoid, in Mice
Lambert, D. M., Vandevoorde, S., Diependaele, G., Govaerts, S. J., & Robert, A. R. (2001) · Epilepsia · doi:10.1046/j.1528-1157.2001.41499.x · Cited by 144
Involvement of the cannabimimetic compound, N-palmitoyl-ethanolamine, in inflammatory and neuropathic conditions: Review of the available pre-clinical data, and first human studies
Darmani, N. A., Izzo, A. A., Degenhardt, B. F., Valenti, M., Scaglione, G., Capasso, R., Sorrentini, I., & Marzo, V. D. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.01.001 · Cited by 144
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Pistis, M., & Melis, M. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710790980014 · Cited by 145
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Sugawara, K., Bíró, T., Tsuruta, D., Tóth, B. I., Kromminga, A., Zákány, N., Zimmer, A., Funk, W., Gibbs, B. F., Zimmer, A., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.11.009 · Cited by 138
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Harvima, I. T., Levi‐Schaffer, F., Dráber, P., Friedman, S., Polakovičová, I., Gibbs, B. F., Blank, U., Nilsson, G. P., & Maurer, M. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.03.007 · Cited by 138
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Samson, M.-T., Small-Howard, A. L., Shimoda, L. M. N., Koblan‐Huberson, M., Stokes, A. J., & Turner, H. C. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.10.4953 · Cited by 139
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Alexander, S. P. H., & Kendall, D. A. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707456 · Cited by 136
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Guida, F., Luongo, L., Boccella, S., Giordano, M., Romano, R., Bellini, G., Manzo, I., Furiano, A., Rizzo, A., Imperatore, R., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00342-1 · Cited by 133
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Involvement of peripheral cannabinoid and opioid receptors in β ‐caryophyllene‐induced antinociception
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Self-citation
Evidence that CB-1 and CB-2 cannabinoid receptors mediate antinociception in neuropathic pain in the rat
Scott, D. A., Wright, C. E., & Angus, J. A. (2004) · Pain · doi:10.1016/j.pain.2004.01.020 · Cited by 129
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Brusco, A., Tagliaferro, P. A., Saez, T. M. M., & Onaivi, E. S. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1432.037 · Cited by 127
Biochemistry of the Endogenous Ligands of Cannabinoid Receptors
Marzo, V. D., & Deutsch, D. G. (1998) · Neurobiology of Disease · doi:10.1006/nbdi.1998.0214 · Cited by 133
Targeting inflammation: New therapeutic approaches in chronic kidney disease (CKD)
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Endocannabinoids: a new class of vasoactive substances
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Alhouayek, M., & Muccioli, G. G. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.06.007 · Cited by 123
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Petrosino, S., Cristino, L., Karsak, M., Gaffal, E., Ueda, N., Tüting, T., Bisogno, T., Filippis, D. D., D’Amico, A., Saturnino, C., et al. (2009) · Allergy · doi:10.1111/j.1398-9995.2009.02254.x · Cited by 120
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Rankin, L., & Fowler, C. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217942 · Cited by 123
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Ross, R. A., Brockie, H. C., & Pertwee, R. G. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00437-4 · Cited by 119
Efficacy and tolerance of the cream containing structured physiological lipids with endocannabinoids in the treatment of uremic pruritus: a preliminary study.
Szepietowski, J. C., Szepietowski, T., & Reich, A. (2005) · PubMed · Cited by 119
Mast cell–glia axis in neuroinflammation and therapeutic potential of the anandamide congener palmitoylethanolamide
Skaper, S. D., & Facci, L. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0391 · Cited by 121
Self-citation
Comparative biology of the endocannabinoid system
Salzet, M., Breton, C., Bisogno, T., & Marzo, V. D. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01550.x · Cited by 119
Endocannabinoids and cannabinoid receptor genetics
Onaivi, E. S., Leonard, C. M., Ishiguro, H., Zhang, P. W., Lin, Z., Akinshola, B. E., & Uhl, G. R. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00007-2 · Cited by 119
Endocannabinoids in the immune system and cancer
Parolaro, D., Massi, P., Rubino, T., & Monti, E. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0355 · Cited by 119
The fatty acid amide hydrolase (FAAH) inhibitor PF‐3845 acts in the nervous system to reverse LPS‐induced tactile allodynia in mice
Booker, L., Kinsey, S. G., Abdullah, R. A., Blankman, J. L., Long, J. Z., Ezzili, C., Boger, D. L., Cravatt, B. F., & Lichtman, A. H. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01445.x · Cited by 116
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Varrassi, G. (2016) · Pain Physician · doi:10.36076/ppj/2016.19.11 · Cited by 116
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Edgemond, W. S., Hillard, C. J., Falck, J. R., Kearn, C. S., & Campbell, W. B. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.1.180 · Cited by 116
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Kehl, L. J., Hamamoto, D. T., Wacnik, P. W., Croft, D. L., Norsted, B. D., Wilcox, G. L., & Simone, D. A. (2003) · Pain · doi:10.1016/s0304-3959(02)00450-5 · Cited by 115
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Cabral, G. A., Ferreira, G. A., & Jamerson, M. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-20825-1_6 · Cited by 118
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Paterniti, I., Impellizzeri, D., Crupi, R., Morabito, R., Campolo, M., Esposito, E., & Cuzzocrea, S. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-20 · Cited by 113
Inflammation of the rat urinary bladder is associated with a referred thermal hyperalgesia which is nerve growth factor dependent
Jaggar, S., Scott, H. C., & Rice, A. S. C. (1999) · British Journal of Anaesthesia · doi:10.1093/bja/83.3.442 · Cited by 113
Analogues and homologues of N-palmitoylethanolamide, a putative endogenous CB2 cannabinoid, as potential ligands for the cannabinoid receptors
Lambert, D. M., DiPaolo, F. G., Sonveaux, P., Kanyonyo, M. R., Govaerts, S. J., Hermans, E., Bueb, J., Delzenne, N. M., & Tschirhart, E. J. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(99)00132-8 · Cited by 113
Endocannabinoids and related fatty acid derivatives in pain modulation
Walker, J. M., Krey, J. F., Chu, C. J., & Huang, S. M. (2002) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(02)00152-4 · Cited by 113
Neuropharmacology of the Endocannabinoid Signaling System-Molecular Mechanisms, Biological Actions and Synaptic Plasticity
Basavarajappa, B. S. (2007) · Current Neuropharmacology · doi:10.2174/157015907780866910 · Cited by 115
Mechanisms of anandamide‐induced vasorelaxation in rat isolated coronary arteries
White, R., Ho, W. ‐. V., Bottrill, F. E., Ford, W. R., & Hiley, C. R. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704333 · Cited by 112
Topische Cannabinoidagonisten
Ständer, S., Reinhardt, H., & Luger, T. A. (2006) · Der Hautarzt · doi:10.1007/s00105-006-1180-1 · Cited by 111
Cannabinoid receptor-inactive N -acylethanolamines and other fatty acid amides: metabolism and function
Schmid, H. H. O., & Berdyshev, E. V. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0348 · Cited by 111
Cardiovascular actions of cannabinoids and their generation during shock
Wagner, J. A., Varga, K. R., & Kunos, G. (1998) · Journal of Molecular Medicine · doi:10.1007/s001090050287 · Cited by 111
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Grabacka, M., Pierzchalska, M., Plonka, P. M., & Pierzchalski, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910545 · Cited by 115
Polymyxin B binds to anandamide and inhibits its cytotoxic effect
Wang, Y., Liu, Y., Sarker, K. P., Nakashima, M. N., Serizawa, T., Kishida, A., Akashi, M., Nakata, M., Kitajima, I., & Maruyama, I. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01313-2 · Cited by 110
Cannabinoids modulate pain by multiple mechanisms of action
Richardson, J. D. (2000) · The Journal of Pain · doi:10.1016/s1526-5900(00)90082-8 · Cited by 109
Inhibitory effect of palmitoylethanolamide on gastrointestinal motility in mice
Capasso, R., Izzo, A. A., Fezza, F., Pinto, A., Capasso, F., Mascolo, N., & Marzo, V. D. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704339 · Cited by 108
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Maccarrone, M., Cecconi, S., Rossi, G., Battista, N., Pauselli, R., & Finazzi‐Agrò, A. (2002) · Endocrinology · doi:10.1210/en.2002-220544 · Cited by 108
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Rukwied, R., Watkinson, A., McGlone, F. P., & Dvorak, M. M. (2003) · Pain · doi:10.1016/s0304-3959(02)00401-3 · Cited by 108
Effects on the Immune System
Cabral, G. A., & Staab, A. (2005) · Handbook of experimental pharmacology · doi:10.1007/3-540-26573-2_13 · Cited by 108
Biochemistry and pharmacology of arachidonylethanolamide, a putative endogenous cannabinoid
Hillard, C. J., & Campbell, W. B. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30024-9 · Cited by 109
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Authors: Facci, L., Dal Toso, R., Romanello, S., Buriani, A., Skaper, S. D., & Leon, A.
Affiliations: Researchlife, Castelfranco Veneto (TV), Italy.
ORCID: Buriani, A
Skaper, S D
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1995-04-11
Volume: 92
Issue: 8
Pages: 3376-3380
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.92.8.3376
PMC: PMC42169
OpenAlex: W1998941878
Cited by: 632
References: 43
Citations by year: 2026: 4 · 2025: 8 · 2024: 14 · 2023: 11 · 2022: 10 · 2021: 13 · 2020: 16 · 2019: 24 · 2018: 13 · 2017: 19 · 2016: 16 · 2015: 11 · 2014: 19 · 2013: 24 · 2012: 28
FWCI: 23.55
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Keywords: mast cells, CB2 receptor, anandamide, palmitoylethanolamide, mast cell activation, inflammation, anti-inflammatory therapy, neuroimmune interactions
MeSH terms: Amides, Animals, Arachidonic Acids, Base Sequence, Cannabinoids, Cell Membrane, Cells, Cultured, Ethanolamines, Inflammation, Male, Mast Cells, Molecular Sequence Data, Morpholines, Naphthalenes, Palmitic Acids, Receptors, Drug, Receptors, Cell Surface, RNA, Messenger, Down-Regulation, Rats, Wistar, Molecular Mimicry, Receptors, Cannabinoid, Receptor, Cannabinoid, CB2, Benzoxazines, Rats, Polyunsaturated Alkamides, Endocannabinoids

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Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide

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