Cited by 633Cannabis and Cannabinoid ResearchMast cells and histamineInflammatory mediators and NSAID effects

The DOI matches its Crossref record; 43 of the 44 references it cites were found in a registry or an index, and 1 are not checked yet.

Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide

Open access

Facci, L, Dal Toso, R, Romanello, S, Buriani, A, Skaper, S D, Leon, A·1995·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.92.8.3376PMC PMC42169

Open this paper in CoChat — free account

Abstract

Mast cells are multifunctional bone marrow-derived cells found in mucosal and connective tissues and in the nervous system, where they play important roles in tissue inflammation and in neuroimmune interactions. Very little is known about endogenous molecules and mechanisms capable of modulating mast cell activation. Palmitoylethanolamide, found in peripheral tissues, has been proposed to behave as a local autacoid capable of downregulating mast cell activation and inflammation. A cognate N-acylamide, anandamide, the ethanolamide of arachidonic acid, occurs in brain and is a candidate endogenous agonist for the central cannabinoid receptor (CB1). As a second cannabinoid receptor (CB2) has been found in peripheral tissues, the possible presence of CB2 receptors on mast cells and their interaction with N-acylamides was investigated. Here we report that mast cells express both the gene and a functional CB2 receptor protein with negative regulatory effects on mast cell activation. Although both palmitoylethanolamide and anandamide bind to the CB2 receptor, only the former downmodulates mast cell activation in vitro. Further, the functional effect of palmitoylethanolamide, as well as that of the active cannabinoids, was efficiently antagonized by anandamide. The results suggest that (i) peripheral cannabinoid CB2 receptors control, upon agonist binding, mast cell activation and therefore inflammation; (ii) palmitoylethanolamide, unlike anandamide, behaves as an endogenous agonist for the CB2 receptor on mast cells; (iii) modulatory activities on mast cells exerted by the naturally occurring molecule strengthen a proposed autacoid local inflammation antagonism (ALIA) mechanism; and (iv) palmitoylethanolamide and its derivatives may provide antiinflammatory therapeutic strategies specifically targeted to mast cells ("ALIAmides").

Integrity signals

Registry

Crossref · 10.1073/pnas.92.8.3376

Cites

43 of 44 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633
Molecular characterization of a peripheral receptor for cannabinoids
Munro, S., Thomas, K. L., & Abu-Shaar, M. (1993) · Nature · doi:10.1038/365061a0 · Cited by 5,092
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011
Determination and characterization of a cannabinoid receptor in rat brain
Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S., & Howlett, A. C. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09876-1 · Cited by 2,443
Inflammation. Basic principles and clinical correlates
(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90156-x · Cited by 2,388
Cannabinoid receptor localization in brain.
Herkenham, M., Lynn, A. B., Little, M. D., Johnson, M. R., Melvin, L. S., de Costa, B. R., & Rice, K. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1932 · Cited by 2,321
Manual of pharmacologic calculations with computer programs
(1988) · International Journal of Biochemistry · doi:10.1016/0020-711x(88)90084-5 · Cited by 1,458
Molecular cloning of a human cannabinoid receptor which is also expressed in testis
Gérard, C. M., Mollereau, C., Vassart, G., & Parmentier, M. (1991) · Biochemical Journal · doi:10.1042/bj2790129 · Cited by 698

Flagged first, then by citations

Show all 43 references

Sorted by citations

Items 301–400 of 633

New Targets in Pain, Non-Neuronal Cells, and the Role of Palmitoylethanolamide
Hesselink, J. M. K. (2012) · The Open Pain Journal · doi:10.2174/1876386301205010012 · Cited by 55
Mast Cells as a Target—A Comprehensive Review of Recent Therapeutic Approaches
Baran, J., Sobiepanek, A., Mazurkiewicz-Pisarek, A., Rogalska, M., Gryciuk, A., Kuryk, Ł., Abraham, S. N., & Staniszewska, M. (2023) · Cells · doi:10.3390/cells12081187 · Cited by 55
Expression of the CB1 cannabinoid receptor in macrophage-like cells from brain tissue: immunochemical characterization by fusion protein antibodies
Sinha, D., Bonner, T. I., Bhat, N. R., & Matsuda, L. A. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00181-1 · Cited by 55
Characterization of palmitoylethanolamide transport in mouse Neuro‐2a neuroblastoma and rat RBL‐2H3 basophilic leukaemia cells: comparison with anandamide
Jacobsson, S. O. P., & Fowler, C. J. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704029 · Cited by 55
Synthesis of 3-aryl-5-decapentyl-1,2,4-oxadiazoles possessing antiinflammatory and antitumor properties
Bezerra, N. M. M., Oliveira, S. P. D., Srivastava, R. M., & Silva, J. R. D. (2005) · Il Farmaco · doi:10.1016/j.farmac.2005.08.003 · Cited by 55
Cannabinoid receptor genes
Onaivi, E. S., Chakrabarti, A. K., & Chaudhuri, G. (1996) · Progress in Neurobiology · doi:10.1016/0301-0082(95)00044-5 · Cited by 55
Palmitoylethanolamide reduces inflammation and itch in a mouse model of contact allergic dermatitis
Vaia, M., Petrosino, S., Filippis, D. D., Negro, L., Guarino, A. M., Carnuccio, R., Marzo, V. D., & Iuvone, T. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.10.005 · Cited by 54
Therapeutic Efficacy of Palmitoylethanolamide and Its New Formulations in Synergy with Different Antioxidant Molecules Present in Diets
Peritore, A. F., Siracusa, R., Crupi, R., & Cuzzocrea, S. (2019) · Nutrients · doi:10.3390/nu11092175 · Cited by 55
Cannabidiol, unlike synthetic cannabinoids, triggers activation of RBL-2H3 mast cells
Giudice, E. D., Rinaldi, L., Passarotto, M., Facchinetti, F., D’Arrigo, A., Guiotto, A., Carbonare, M. D., Battistin, L., & Leon, A. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.1206738 · Cited by 54
Self-citation
Immune regulation by cannabinoid compounds through the inhibition of the cyclic AMP signaling cascade and altered gene expression
Kaminski, N. E. (1996) · Biochemical Pharmacology · doi:10.1016/0006-2952(96)00480-7 · Cited by 53
Cannabinoid receptor agonists and antagonists
Barth, F. (1998) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.8.3.301 · Cited by 52
Antinociceptive effects of the non-selective cannabinoid receptor agonist CP 55,940 are absent in CB1(−/−) and not CB2(−/−) mice in models of acute and persistent pain
Sain, N. M. H., Liang, A., Kane, S. A., & Urban, M. O. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.004 · Cited by 51
Design and Synthesis of Potent N-Acylethanolamine-hydrolyzing Acid Amidase (NAAA) Inhibitor as Anti-Inflammatory Compounds
Li, Y., Yang, L., Chen, L., Zhu, C., Huang, R., Zheng, X., Qiu, Y., & Fu, J. X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043023 · Cited by 50
Palmitoylethanolamide protects mice against 6-OHDA-induced neurotoxicity and endoplasmic reticulum stress: In vivo and in vitro evidence
Avagliano, C., Russo, R., Caro, C. D., Cristiano, C., Rana, G. L., Piegari, G., Paciello, O., Citraro, R., Russo, E., Sarro, G. D., et al. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.09.004 · Cited by 50
The Cannabinoid 1 Receptor Antagonist, AM251, Prolongs the Survival of Rats with Severe Acute Pancreatitis
Matsuda, K., Mikami, Y., Takeda, K., Fukuyama, S., Egawa, S., Sunamura, M., Maruyama, I., & Matsuno, S. (2005) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.207.99 · Cited by 50
The cannabinoid receptor type 2 is time-dependently expressed during skeletal muscle wound healing in rats
Yu, T.-S., Cheng, Z.-H., Li, L., Zhao, R., Fan, Y., Du, Y., Ma, W.-X., & Guan, D.-W. (2010) · International Journal of Legal Medicine · doi:10.1007/s00414-010-0465-1 · Cited by 49
Possible Anandamide and Palmitoylethanolamide involvement in human stroke
Naccarato, M., Pizzuti, D., Petrosino, S., Simonetto, M., Ferigo, L., Grandi, F., Pizzolato, G., & Marzo, V. D. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-47 · Cited by 49
Stereochemical Selectivity of Methanandamides for the CB1 and CB2 Cannabinoid Receptors and Their Metabolic Stability
Goutopoulos, A., Fan, P., Khanolkar, A. D., Xie, X.-Q., Lin, S., & Makriyannis, A. (2001) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(01)00088-8 · Cited by 49
Role of metabolic programming in the modulation of microglia phagocytosis by lipids
Nadjar, A. (2018) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2018.07.006 · Cited by 49
Medicinal Marijuana: A Comprehensive Review
Gurley, R. J., Aranow, R., & Katz, M. H. (1998) · Journal of Psychoactive Drugs · doi:10.1080/02791072.1998.10399683 · Cited by 49
Adelmidrol, a palmitoylethanolamide analogue, reduces chronic inflammation in a carrageenin‐granuloma model in rats
Filippis, D. D., D’Amico, A., Cinelli, M. P., Esposito, G., Marzo, V. D., & Iuvone, T. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00353.x · Cited by 49
Fetal Alcohol Spectrum Disorder: Potential Role of Endocannabinoids Signaling
Basavarajappa, B. S. (2015) · Brain Sciences · doi:10.3390/brainsci5040456 · Cited by 48
Palmitoylethanolamide Modulation of Microglia Activation: Characterization of Mechanisms of Action and Implication for Its Neuroprotective Effects
D’Aloia, A., Molteni, L., Gullo, F., Bresciani, E., Artusa, V., Rizzi, L., Ceriani, M., Meanti, R., Lecchi, M., Coco, S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063054 · Cited by 48
Effects of the cannabimimetic fatty acid derivatives 2-arachidonoylglycerol, anandamide, palmitoylethanolamide and methanandamide upon IgE-dependent antigen-induced β-hexosaminidase, serotonin and TNFα release from rat RBL-2H3 basophilic leukaemia cells
Granberg, M., Fowler, C. J., & Jacobsson, S. O. P. (2001) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002100100424 · Cited by 48
The antinociceptive effect of Δ9-tetrahydrocannabinol in the arthritic rat involves the CB2 cannabinoid receptor
Cox, M. L., Haller, V. L., & Welch, S. P. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.05.024 · Cited by 48
Anti-Microbial Activity of Phytocannabinoids and Endocannabinoids in the Light of Their Physiological and Pathophysiological Roles
Sionov, R. V., & Steinberg, D. (2022) · Biomedicines · doi:10.3390/biomedicines10030631 · Cited by 51
The Endocannabinoid 2-Arachidonylglycerol Decreases the Immunological Activation of Guinea Pig Mast Cells: Involvement of Nitric Oxide and Eicosanoids
Vannacci, A., Giannini, L., Passani, M. B., Felice, A. D., Pierpaoli, S., Zagli, G., Fantappiè, O., Mazzanti, R., Masini, E., & Mannaioni, P. F. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.068635 · Cited by 47
Activation of CB2 receptors as a potential therapeutic target for migraine: evaluation in an animal model
Greco, R., Mangione, A. S., Sandrini, G., Nappi, G., & Tassorelli, C. (2014) · The Journal of Headache and Pain · doi:10.1186/1129-2377-15-14 · Cited by 46
Fatty Acid Synthase as a Factor Required for Exercise-Induced Cognitive Enhancement and Dentate Gyrus Cellular Proliferation
Chorna, N., Santos-Soto, I. J., Carballeira, N. M., Morales, J. L., de la Nuez, J., Cátala-Valentin, A., Chornyy, A. P., Vázquez, A., & de Ortı́z, S. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077845 · Cited by 47
Electroacupuncture Increases CB2 Receptor Expression on Keratinocytes and Infiltrating Inflammatory Cells in Inflamed Skin Tissues of Rats
Zhang, J., Chen, L., Su, T., Cao, F., Meng, X., Pei, L., Shi, J., Pan, H., & Li, M. (2010) · Journal of Pain · doi:10.1016/j.jpain.2010.02.013 · Cited by 46
Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse
Roviezzo, F., Rossi, A., Caiazzo, E., Orlando, P., Riemma, M. A., Iacono, V. M., Guarino, A. M., Ialenti, A., Cicala, C., Peritore, A. F., et al. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00857 · Cited by 46
New Perspectives in the Studies on Endocannabinoid and Cannabis: 2-Arachidonoylglycerol as a Possible Novel Mediator of Inflammation
Sugiura, T., Oka, S., Gokoh, M., Kishimoto, S., & Waku, K. (2004) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fmj04003x3 · Cited by 46
Activation of the cannabinoid 2 (CB2) receptor inhibits murine mesenteric afferent nerve activity
Hillsley, K., Mccaul, C., Aerssens, J., Peeters, P. J., Gijsen, H. J. M., Moechars, D., Coulie, B. J., Grundy, D., & Stead, R. H. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00950.x · Cited by 45
Ontogenetic development of the response to anandamide and Δ9-tetrahydrocannabinol in mice
Fride, E., & Mechoulam, R. (1996) · Developmental Brain Research · doi:10.1016/0165-3806(96)00087-9 · Cited by 45
The adjuvant use of N-palmitoylethanolamine and transpolydatin in the treatment of endometriotic pain
Giugliano, E., Cagnazzo, E., Soave, I., Monte, G. L., Wenger, J. M., & Marci, R. (2013) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2013.01.009 · Cited by 44
The cannabinoid CB2 receptor inverse agonist JTE-907 suppresses spontaneous itch-associated responses of NC mice, a model of atopic dermatitis
Maekawa, T., Nojima, H., Kuraishi, Y., & Aisaka, K. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.05.040 · Cited by 44
Cannabinoid receptor‐independent actions of the aminoalkylindole WIN 55,212‐2 on trigeminal sensory neurons
Price, T. J., Patwardhan, A. M., Akopian, A. N., Hargreaves, K., & Flores, C. M. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705778 · Cited by 43
Methods to Study the Behavioral Effects and Expression of CB2 Cannabinoid Receptor and Its Gene Transcripts in the Chronic Mild Stress Model of Depression
Onaivi, E. S., Ishiguro, H., Sejal, P., Meozzi, P. A., Myers, L., Tagliaferro, P. A., Hope, B. T., Leonard, C. M., Uhl, G. R., & Brusco, A. (2006) · Humana Press eBooks · doi:10.1385/1-59259-999-0:291 · Cited by 43
Emollients With Endocannabinoids in the Treatment of Uremic Pruritus: Discussion of the Therapeutic Options
Szepietowski, J. C., Reich, A., & Szepietowski, T. (2005) · Therapeutic Apheresis and Dialysis · doi:10.1111/j.1774-9987.2005.00271.x · Cited by 43
Role of Endocannabinoid Activation of Peripheral CB1 Receptors in the Regulation of Autoimmune Disease
Sido, J. M., Nagarkatti, P. S., & Nagarkatti, M. (2014) · International Reviews of Immunology · doi:10.3109/08830185.2014.921165 · Cited by 43
Ultramicronized palmitoylethanolamide reduces viscerovisceral hyperalgesia in a rat model of endometriosis plus ureteral calculosis
Iuvone, T., Affaitati, G., Filippis, D. D., Lopopolo, M., Grassia, G., Lapenna, D., Negro, L., Costantini, R., Vaia, M., Cipollone, F., et al. (2015) · Pain · doi:10.1097/j.pain.0000000000000220 · Cited by 42
Peripheral and spinal activation of cannabinoid receptors by joint mobilization alleviates postoperative pain in mice
Martins, D. F., Mazzardo‐Martins, L., Cidral‐Filho, F. J., Gadotti, V. M., & Santos, A. R. S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.09.055 · Cited by 42
The Role of Cannabinoids in Inflammatory Modulation of Allergic Respiratory Disorders, Inflammatory Pain and Ischemic Stroke
Pini, A., Mannaioni, G., Pellegrini-Giampietro, D. E., Passani, M. B., Mastroianni, R., Bani, D., & Masini, E. (2012) · Current Drug Targets · doi:10.2174/138945012800675786 · Cited by 41
Dietary therapy: a new strategy for management of chronic pelvic pain
Sesti, F., Capozzolo, T., Pietropolli, A., Collalti, M., Bollea, M. R., & Piccione, E. (2010) · Nutrition Research Reviews · doi:10.1017/s0954422410000272 · Cited by 41
Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 by macrophages and increases the resistance of mice against infections
Redlich, S., Ribes, S., Schütze, S., & Nau, R. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-108 · Cited by 41
Chronic prostatitis: current treatment options
Pirola, G. M., Verdacchi, T., Rosadi, S., Annino, F., & Angelis, M. D. (2019) · Research and Reports in Urology · doi:10.2147/rru.s194679 · Cited by 40
CB2 cannabinoid receptor antagonist SR144528 decreases mu-opioid receptor expression and activation in mouse brainstem: Role of CB2 receptor in pain
Páldy, E., Bereczki, E., Sántha, M., Wenger, T., Borsodi, A. D., Zimmer, A., & Benyhe, S. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.08.005 · Cited by 40
Endocannabinoid structure–activity relationships for interaction at the cannabinoid receptors
Reggio, P. H. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0343 · Cited by 40
Marijuana and Cannabinoids
Cabral, G. A. (2001) · Journal of Cannabis Therapeutics · doi:10.1300/j175v01n03_06 · Cited by 39
Molecular packing and intermolecular interactions in N-acylethanolamines: crystal structure of N-myristoylethanolamine
Ramakrishnan, M., & Swamy, M. J. (1999) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(99)00035-8 · Cited by 39
Differences in the pharmacological properties of rat and chicken brain fatty acid amidohydrolase
Fowler, C. J., Börjesson, M., & Tiger, G. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703569 · Cited by 38
Receptor-independent effects of natural cannabinoids in rat peritoneal mast cells in vitro
Bueb, J., Lambert, D. M., & Tschirhart, E. J. (2001) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(01)00076-3 · Cited by 38
Amino acid residues crucial in pH regulation and proteolytic activation of N-acylethanolamine-hydrolyzing acid amidase
Wang, J., Zhao, L., Uyama, T., Tsuboi, K., Tonai, T., & Ueda, N. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.08.004 · Cited by 37
Derivatised lipids in membranes. Physico-chemical aspects of N-biotinyl phosphatidylethanolamines, N-acyl phosphatidylethanolamines and N-acyl ethanolamines
Marsh, D., & Swamy, M. J. (2000) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(99)00132-2 · Cited by 37
Cannabinoids: Potential Targets for Bladder Dysfunction
Ruggieri, M. R. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-16499-6_20 · Cited by 36
Administration of N-Acyl-Phosphatidylethanolamine Expressing Bacteria to Low Density Lipoprotein Receptor−/− Mice Improves Indices of Cardiometabolic Disease
Zhang, L., Chen, Z., Dosoky, N. S., Yancey, P. G., Boyd, K. L., Hasty, A. H., Linton, M. F., & Davies, S. S. (2019) · Scientific Reports · doi:10.1038/s41598-018-37373-1 · Cited by 36
Modulation of P‐glycoprotein activity by cannabinoid molecules in HK‐2 renal cells
Nieri, P., Romiti, N., Adinolfi, B., Chicca, A., Massarelli, I., & Chieli, E. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706778 · Cited by 36
The cannabinoid CB2 receptor selective agonist JWH133 reduces mast cell oedema in response to compound 48/80 in vivo but not the release of β-hexosaminidase from skin slices in vitro
Jonsson, K., Persson, E., & Fowler, C. J. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.05.059 · Cited by 36
ETHANOL INDUCES HIGHER BEC IN CB1 CANNABINOID RECEPTOR KNOCKOUT MICE WHILE DECREASING ETHANOL PREFERENCE
Lallemand, F., & de Witte, P. A. M. (2004) · Alcohol and Alcoholism · doi:10.1093/alcalc/agh115 · Cited by 36
Localization of cannabinoid and cannabinoid related receptors in the cat gastrointestinal tract
Stanzani, A., Galiazzo, G., Giancola, F., Tagliavia, C., Silva, M. D., Pietra, M., Fracassi, F., & Chiocchetti, R. (2020) · Histochemistry and Cell Biology · doi:10.1007/s00418-020-01854-0 · Cited by 38
A role for the endogenous cannabinoid system in the peripheal control of pain initiation
Calignano, A., Rana, G. L., Loubet‐Lescoulié, P., & Piomelli, D. (2000) · Progress in brain research · doi:10.1016/s0079-6123(00)29034-1 · Cited by 34
Evolution in pharmacologic thinking around the natural analgesic palmitoylethanolamide: from nonspecific resistance to PPAR-α agonist and effective nutraceutical
Hesselink, J. M. K. (2013) · Journal of Pain Research · doi:10.2147/jpr.s48653 · Cited by 34
Effects of cannabinoid receptor agonists on immunologically induced histamine release from rat peritoneal mast cells
Lau, H. Y. A., & Chow, S. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01430-4 · Cited by 34
Cannabinoids reduce granuloma‐associated angiogenesis in rats by controlling transcription and expression of mast cell protease‐5
Filippis, D. D., Russo, A., D’Amico, A., Esposito, G., Potenza, C., Cinelli, M. P., Russo, G., & Iuvone, T. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.211 · Cited by 34
Membrane localization of N-acylphosphatidylethanolamine in central neurons: Studies with exogenous phospholipases
Cadas, H., Schinelli, S., & Piomelli, D. (1996) · Journal of Lipid Mediators and Cell Signalling · doi:10.1016/0929-7855(96)00510-x · Cited by 34
Molecular packing and intermolecular interactions in two structural polymorphs of N-palmitoylethanolamine, a type 2 cannabinoid receptor agonist
Kamlekar, R. K., & Swamy, M. J. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600043-jlr200 · Cited by 34
Δ9-Tetrahydrocannabinol stimulates glucose utilization in C6 glioma cells
Sánchez, C., Velasco, G., & Guzmán, M. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00631-8 · Cited by 34
2‐Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, enhances the adhesion of HL‐60 cells differentiated into macrophage‐like cells and human peripheral blood monocytes
Gokoh, M., Kishimoto, S., Oka, S., Yasuchika, M., & Sugiura, T. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.10.030 · Cited by 33
Cannabinoids and Reproduction: A Lasting and Intriguing History
Cacciola, G., Chianese, R., Chioccarelli, T., Ciaramella, V., Fasano, S., Pierantoni, R., Meccariello, R., & Cobellis, G. (2010) · Pharmaceuticals · doi:10.3390/ph3103275 · Cited by 33
Activation of rabbit blood platelets by anandamide through its cleavage into arachidonic acid
Braud, S., Bon, C., Touqui, L., & Mounier, C. M. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01359-4 · Cited by 33
Synthesis, calorimetric studies, and crystal structures of N, O-diacylethanolamines with matched chains
Kamlekar, R. K., Tarafdar, P. K., & Swamy, M. J. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m900105-jlr200 · Cited by 32
Role of palmitoylethanolamide (PEA) in depression: Translational evidence
Gregorio, D. D., Manchia, M., Carpiniello, B., Valtorta, F., Nobile, M., Gobbi, G., & Comai, S. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.10.117 · Cited by 34
Cellular Targeting of Oligonucleotides by Conjugation with Small Molecules
Hawner, M., & Ducho, C. (2020) · Molecules · doi:10.3390/molecules25245963 · Cited by 31
The non-selective cannabinoid receptor agonist WIN 55,212-2 attenuates responses of C-fiber nociceptors in a murine model of cancer pain
Uhelski, M. L., Cain, D. M., Harding-Rose, C., & Simone, D. A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.05.003 · Cited by 30
µ‐opioid receptor, β‐endorphin, and cannabinoid receptor‐2 are increased in the colonic mucosa of irritable bowel syndrome patients
Dothel, G., Chang, L., Shih, W., Barbaro, M. R., Cremon, C., Stanghellini, V., Ponti, F. D., Mayer, E. A., Barbara, G., & Sternini, C. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13688 · Cited by 30
Cannabinoid receptors in the inflammatory cells of canine atopic dermatitis
Chiocchetti, R., Salamanca, G., Silva, M. D., Gobbo, F., Aspidi, F., Cunha, R. Z., Galiazzo, G., Tagliavia, C., Sarli, G., & Morini, M. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.987132 · Cited by 29
Local Peripheral Effects of β-Caryophyllene through CB2 Receptors in Neuropathic Pain in Mice
Kuwahata, H., Katsuyama, S., Komatsu, T., Nakamura, H., Corasaniti, M. T., Bagetta, G., Sakurada, S., Sakurada, T., & Takahama, K. (2012) · Pharmacology & Pharmacy · doi:10.4236/pp.2012.34053 · Cited by 29
Pain and beyond: fatty acid amides and fatty acid amide hydrolase inhibitors in cardiovascular and metabolic diseases
Pillarisetti, S., Alexander, C. W., & Khanna, I. (2009) · Drug Discovery Today · doi:10.1016/j.drudis.2009.08.002 · Cited by 29
Randomized Split-Mouth Study on Postoperative Effects of Palmitoylethanolamide for Impacted Lower Third Molar Surgery
Bacci, C., Cassetta, G., Emanuele, B., & Berengo, M. (2011) · ISRN Surgery · doi:10.5402/2011/917350 · Cited by 29
Characterization of Peripheral Human Cannabinoid Receptor (hCB2) Expression and Pharmacology Using a Novel Radioligand, [35S]Sch225336
Gonsiorek, W., Hesk, D., Chen, S., Kinsley, D., Fine, J. S., Jackson, J. V., Bober, L. A., Deno, G., Bian, H., Fossetta, J. D., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602364200 · Cited by 29
The Role of Cannabinoids in Allergic Diseases: Collegium Internationale Allergologicum (CIA) Update 2020
Angelina, A., Pérez‐Diego, M., López‐Abente, J., & Palomares, Ó. (2020) · International Archives of Allergy and Immunology · doi:10.1159/000508989 · Cited by 30
A New Palmitoylethanolamide Form Combined with Antioxidant Molecules to Improve Its Effectivess on Neuronal Aging
Morsanuto, V., Galla, R., Molinari, C. G., & Uberti, F. (2020) · Brain Sciences · doi:10.3390/brainsci10070457 · Cited by 29
Effect of the enzyme inhibitor, phenylmethylsulfonyl fluoride, on the IOP profiles of topical anandamides.
Laine, K., Järvinen, K., Pate, D. W., Urtti, A. O., & Järvinen, T. (2002) · PubMed · Cited by 29
Cannabidiol and Cannabigerol, Nonpsychotropic Cannabinoids, as Analgesics that Effectively Manage Bone Fracture Pain and Promote Healing in Mice
Khajuria, D. K., Karuppagounder, V., Nowak, I., Sepúlveda, D. E., Lewis, G. S., Norbury, C. C., Raup‐Konsavage, W. M., Vrana, K. E., Kamal, F., & Elbarbary, R. A. (2023) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4902 · Cited by 30
Tolerability of Palmitoylethanolamide in a Pediatric Population Suffering from Migraine: A Pilot Study
Papetti, L., Sforza, G., Tullo, G., Loro, P. A. D., Moavero, R., Ursitti, F., Ferilli, M. A. N., Tarantino, S., Vigevano, F., & Valeriani, M. (2020) · Pain Research and Management · doi:10.1155/2020/3938640 · Cited by 29
Future treatment options for atopic dermatitis – Small molecules and beyond
Schäkel, K., Döbel, T., & Bosselmann, I. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.11.009 · Cited by 28
Differences in peripheral endocannabinoid modulation of scratching behavior in facial vs. spinally-innervated skin
Spradley, J. M., Davoodi, A., Gee, L. B., Carstens, M. I., & Carstens, E. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.05.032 · Cited by 28
Design and evaluation of a novel fluorescent CB2 ligand as probe for receptor visualization in immune cells
Petrov, R. R., Ferrini, M. E., Jaffar, Z. H., Thompson, C. M., Roberts, K., & Diaz, P. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.07.099 · Cited by 29
N-Palmitoylethanolamine depot injection increased its tissue levels and those of other acylethanolamide lipids
Koulen, P., Grillo, Keereetaweep, J., Grillo, & Chapman, K. D. (2013) · Drug Design Development and Therapy · doi:10.2147/dddt.s48324 · Cited by 28
PEA and luteolin synergistically reduce mast cell-mediated toxicity and elicit neuroprotection in cell-based models of brain ischemia
Parrella, E., Porrini, V., Iorio, R. A., Benarese, M., Lanzillotta, A., Mota, M., Fusco, M., Tonin, P., Spano, P., & Pizzi, M. (2016) · Brain Research · doi:10.1016/j.brainres.2016.07.014 · Cited by 28
Effect of palmitoylethanolamide on inflammatory and neuropathic pain in rats
Seol, T., Lee, W., Park, S., Kim, K. N., Kim, T. Y., Oh, Y. N., & Jun, J. H. (2017) · Korean Journal of Anesthesiology · doi:10.4097/kjae.2017.70.5.561 · Cited by 28
The Peripheral Cannabinoid Receptor, Cb2, in Retrovirally-Induced Leukemic Transformation and Normal Hematopoiesis
Valk, P. J. M., & Delwel, R. (1998) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199809059244 · Cited by 28
A comprehensive review of the multifaceted role of cannabinoid receptor type 2 in neurodegenerative and neuropsychiatric disorders
García‐Gutiérrez, M. S., Torregrosa, A. B., Navarrete, F., Navarro, D., & Manzanares, J. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107657 · Cited by 27
The role of the endocannabinoid system in aetiopathogenesis of endometriosis: A potential therapeutic target
Tanaka, K., Mayne, L., Khalil, A., Baartz, D., Eriksson, L., Mortlock, S., Montgomery, G. W., McKinnon, B. D., & Amoako, A. A. (2019) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2019.11.012 · Cited by 27
Structure, phase behaviour and membrane interactions of N-acylethanolamines and N-acylphosphatidylethanolamines
Swamy, M. J., Tarafdar, P. K., & Kamlekar, R. K. (2010) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2010.01.002 · Cited by 27
Determination of physicochemical properties of delipidized hair.
McMullen, R. L., Laura, D., Chen, S. E., Koelmel, D., Zhang, G., & Gillece, T. W. (2013) · PubMed · Cited by 27
Enterocolic increase of cannabinoid receptor type 1 and type 2 and clinical improvement after probiotic administration in dogs with chronic signs of colonic dysmotility without mucosal inflammatory changes
Rossi, G., Gioacchini, G., Pengo, G., Suchodolski, J. S., Jergens, A. E., Allenspach, K., Gavazza, A., Scarpona, S., Berardi, S., Galosi, L., et al. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13717 · Cited by 27
Surface mass spectrometry of molecular species
Hanley, L., Kornienko, O., Ada, E. T., Fuoco, E. R., & Trevor, J. L. (1999) · Journal of Mass Spectrometry · doi:10.1002/(sici)1096-9888(199907)34:7 · Cited by 80
Cannabis sativa: Interdisciplinary Strategies and Avenues for Medical and Commercial Progression Outside of CBD and THC
Oultram, J. M. J., Pegler, J. L., Bowser, T. A., Ney, L. J., Eamens, A. L., & Grof, C. P. L. (2021) · Biomedicines · doi:10.3390/biomedicines9030234 · Cited by 30
Short-Term Efficacy of Ultramicronized Palmitoylethanolamide in Peripheral Neuropathic Pain
Cocito, D., Peci, E., Ciaramitaro, P., Merola, A., & Lopiano, L. (2014) · Pain Research and Treatment · doi:10.1155/2014/854560 · Cited by 26

Authors: Facci, L., Dal Toso, R., Romanello, S., Buriani, A., Skaper, S. D., & Leon, A.
Affiliations: Researchlife, Castelfranco Veneto (TV), Italy.
ORCID: Buriani, A
Skaper, S D
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1995-04-11
Volume: 92
Issue: 8
Pages: 3376-3380
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.92.8.3376
PMC: PMC42169
OpenAlex: W1998941878
Cited by: 632
References: 43
Citations by year: 2026: 4 · 2025: 8 · 2024: 14 · 2023: 11 · 2022: 10 · 2021: 13 · 2020: 16 · 2019: 24 · 2018: 13 · 2017: 19 · 2016: 16 · 2015: 11 · 2014: 19 · 2013: 24 · 2012: 28
FWCI: 23.55
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Keywords: mast cells, CB2 receptor, anandamide, palmitoylethanolamide, mast cell activation, inflammation, anti-inflammatory therapy, neuroimmune interactions
MeSH terms: Amides, Animals, Arachidonic Acids, Base Sequence, Cannabinoids, Cell Membrane, Cells, Cultured, Ethanolamines, Inflammation, Male, Mast Cells, Molecular Sequence Data, Morpholines, Naphthalenes, Palmitic Acids, Receptors, Drug, Receptors, Cell Surface, RNA, Messenger, Down-Regulation, Rats, Wistar, Molecular Mimicry, Receptors, Cannabinoid, Receptor, Cannabinoid, CB2, Benzoxazines, Rats, Polyunsaturated Alkamides, Endocannabinoids

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks