The DOI matches its Crossref record; 40 of the 41 references it cites were found in a registry or an index.
A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria.
Open accessAbstract
A novel Saccharomyces cerevisiae mutant, unable to grow in the presence of 12.5 mM EGTA, was isolated by replica plating. The phenotype of the mutant is caused by a single amino acid change (Gly149 to Arg) in the essential yeast gene CDC1. The mutant could be suppressed by overexpression of the SMF1 gene, which was isolated as an extragenic high-copy suppressor. The SMF1 gene codes for a highly hydrophobic protein and its deletion renders the yeast cells sensitive to low manganese concentration. In accordance with this observation, the smf1 null mutant exhibits reduced Mn2+ uptake at micromolar concentrations. Using a specific antibody, we demonstrated that Smf1p is located in the yeast plasma membrane. These results suggest that Smf1p is involved in high-affinity Mn2+ uptake. This assumption was also tested by overexpressing the SMF1 gene in the temperature-sensitive mutant of the mitochondrial processing peptidase (MAS1). SMF1 overexpression as well as addition of 1 mM Mn2+ to the growth medium complemented this mutation. This also suggests that in vivo Mas1p is a manganese-dependent peptidase. The yeast Smf1p resembles a protein from Drosophila and mammalian macrophages. The latter was implicated in conferring resistance to mycobacteria. A connection between Mn2+ transport and resistance or sensitivity to mycobacteria is discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Homologous proteins in yeast, 63 flies, 64 and zebrafish 65 also transport iron and similar divalent cations.”
From Forging a field: the golden age of iron biology. (2008) · cites this paper as [63]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
DNA sequencing with chain-terminating inhibitors
Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572
Transformation of intact yeast cells treated with alkali cations
Ito, H., Fukuda, Y., Murata, K., & Kimura, A. (1983) · Journal of Bacteriology · doi:10.1128/jb.153.1.163-168.1983 · Cited by 7,518
Sherman, F. (1991) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(91)94004-v · Cited by 4,078
Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast.
Rothstein, R. (1991) · Methods in Enzymology · doi:10.1016/0076-6879(91)94022-5 · Cited by 1,283
Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg
Vidal, S. M., Malo, D., Vogan, K., Skamene, E., & Gros, P. (1993) · Cell · doi:10.1016/0092-8674(93)90135-d · Cited by 1,104
ZINC PROTEINS: Enzymes, Storage Proteins, Transcription Factors, and Replication Proteins
Coleman, J. E. (1992) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.61.070192.004341 · Cited by 980
The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake.
Askwith, C., Eide, D., Van Ho, A., Bernard, P. S., Li, L., Davis-Kaplan, S., Sipe, D. M., & Kaplan, J. (1994) · Cell · doi:10.1016/0092-8674(94)90346-8 · Cited by 670
Dancis, A., Yuan, D. S., Haile, D., Askwith, C., Eide, D., Moehle, C., Kaplan, J., & Klausner, R. D. (1994) · Cell · doi:10.1016/0092-8674(94)90345-x · Cited by 659
Goud, B., Salminen, A., Walworth, N. C., & Novick, P. (1988) · Cell · doi:10.1016/0092-8674(88)90093-1 · Cited by 585
The yeast secretory pathway is perturbed by mutations in PMR1, a member of a Ca2+ ATPase family
Rudolph, H. K., Antebi, A., Fink, G. R., Buckley, C. M. F., Dorman, T. E., LeVitre, J., Davidow, L. S., Mao, J.-I., & Moir, D. T. (1989) · Cell · doi:10.1016/0092-8674(89)90410-8 · Cited by 536
Research works printed but not linked: 4
- [8]Rooney, E. K. & Gross, J. D. (1992) Proc. Natl. Acad. Sci. USA 89, 8025-8029.
- [13]Noumi, T., Beltrán, C., Nelson, H. & Nelson, N. (1991) Proc. Natl. Acad. Sci. USA 88, 1938–1942.
- [17]Maniatis, T., Fritsch, E. F. & Sambrook, J. (1984) Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Lab. Press, Plainview, NY), pp. 88–148.
- [19]Sanger, F., Nicklen, S. & Coulson, A. R. (1977) Proc. Natl. Acad. Sci. USA 74, 5463–5467.
Cited by
Sorted by citations
Items 301–324 of 324
IRON AND ERYTHROPOIESIS Lessons from Anemic Mice
Andrews, N. C., & Fleming, M. D. (1999) · Cited by 1
van Dam, J. C. J. (2019) · doi:10.18174/464871 · Cited by 1
Clemens, S., Thomine, S., & Schroeder, J. I. (2002) · CRC Press eBooks · doi:10.1201/9780203910849.ch27 · Cited by 1
Nelson, N. (2002) · Wiley Encyclopedia of Molecular Medicine · doi:10.1002/0471203076.emm0926
Glucocorticoid regulation of Nramp1 in host resistance to mycobacteria
Brown, D. H., & Zwilling, B. S. (1997) · Springer eBooks · doi:10.1007/978-1-4471-0931-0_8
The diversity of the radio-resistant bacteriaDeinococcus radiodurans
Zhenli, 屠. T., Lijing, 方. F., & Jiagang, 王. W. (2012) · Acta Ecologica Sinica · doi:10.5846/stxb201101070029
Polymorphism of SLC11A1 gene in Doom pigs of Asom
DEVI, B., Laskar, S. K., Borah, P., KALITA, D. J., Zaman, G. U., Ferdoci, A. M., & Hussain, I. (2015) · The Indian Journal of Animal Sciences · doi:10.56093/ijans.v85i4.47853
Mechanisms of Cadmium Transport in Mammalian Cells
Fujishiro, H., Sakurai, T., & Himeno, S. (2006) · Biomedical research on trace elements · doi:10.11299/brte.17.349
Papel de MtNramp1, MtYSL1, MtYSL8 en la homeostasis de metales en el nódulo de Medicago truncatula
Rodríguez, M. D. R. C. (2017) · doi:10.20868/upm.thesis.48534
Moteshareie, H. (2019) · Carleton University's Institutional Repository (MacOdrum Library, Carleton University) · doi:10.22215/etd/2019-13407
Study on peptide-peptide interactions between transmembrane domains of Slc11a1 in model membranes
Qi, H., Wang, X., Su, L., Wang, S., & Wang, Y. (2021) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2021.119594
Evolution of quantitative trait locus hotspots in yeast speciesPreprint
Peltier, É., Bibi‐Triki, S., Dutreux, F., Caradec, C., Friedrich, A., Llorente, B., & Schacherer, J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.07.438839
Transport of Iron in Health and Diseases
Rolfs, A., & Hediger, M. A. (2002) · Springer eBooks · doi:10.1007/0-306-47466-2_256
La fascinadora bellesa dels vells llibres escrits a mà
Marcet, A. M. M. (2001) · Serra d'Or
Yim, J., & Holland, S. M. (2004) · Springer eBooks · doi:10.1007/978-3-642-18937-1_11
Nicolaus Von Wirén, A. (2005) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1029905.347659
Susceptibilité mendélienne aux maladies infectieuses chez l'homme : déficits en NEMO et NRAMP1
Hubeau, M. (2013) · theses.fr (ABES) · doi:10.70675/3a76475dz8fbdz46b9z8759z2e9f0feaa160
Characterization of poplar metal transporters to improve rehabilitation of metal polluted soils
Thi, V. A. L. (2015) · theses.fr (ABES) · doi:10.70675/788b8abfza866z4272za56cz64d837ead6aa
Regulation of cellular Mn homeostasis : unexpected functions of TMEM165, SERCA and SPCA1
Houdou, M. (2020) · theses.fr (ABES) · doi:10.70675/3f8f8e86z4809z4fceza763z96ca8df1ea4b
Metadata
- Authors
- Supek, F., Supekova, L., Nelson, H., & Nelson, N.
- Affiliations
- Roche Institute of Molecular Biology, Nutley, NJ 07110, USA.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1996-05-14
- Volume
- 93
- Issue
- 10
- Pages
- 5105-5110
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC39414
- OpenAlex
- W2015326313
- Cited by
- 325
- References
- 41
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 7 · 2022: 10 · 2021: 11 · 2020: 9 · 2019: 8 · 2018: 6 · 2017: 8 · 2016: 3 · 2015: 10 · 2014: 9 · 2013: 5 · 2012: 5
- FWCI
- 10.74
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- manganese transporter, manganese deficiency, plasma membrane proteins, mitochondrial processing peptidase, Mas receptor, extragenic suppressors, Saccharomyces cerevisiae mutants
- MeSH terms
- Mitochondrial Processing Peptidase, Amino Acid Sequence, Animals, Biological Transport, Active, Carrier Proteins, Fungal Proteins, Genes, Fungal, Genetic Complementation Test, Macrophages, Manganese, Membrane Proteins, Metalloendopeptidases, Molecular Sequence Data, Mycobacterium, Phenotype, Saccharomyces cerevisiae, Point Mutation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
