Cited by 325Fungal and yeast genetics researchHeavy Metal Exposure and ToxicityTrace Elements in Health

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A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria.

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Supek, F, Supekova, L, Nelson, H, Nelson, N·1996·Proceedings of the National Academy of Sciences

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Abstract

A novel Saccharomyces cerevisiae mutant, unable to grow in the presence of 12.5 mM EGTA, was isolated by replica plating. The phenotype of the mutant is caused by a single amino acid change (Gly149 to Arg) in the essential yeast gene CDC1. The mutant could be suppressed by overexpression of the SMF1 gene, which was isolated as an extragenic high-copy suppressor. The SMF1 gene codes for a highly hydrophobic protein and its deletion renders the yeast cells sensitive to low manganese concentration. In accordance with this observation, the smf1 null mutant exhibits reduced Mn2+ uptake at micromolar concentrations. Using a specific antibody, we demonstrated that Smf1p is located in the yeast plasma membrane. These results suggest that Smf1p is involved in high-affinity Mn2+ uptake. This assumption was also tested by overexpressing the SMF1 gene in the temperature-sensitive mutant of the mitochondrial processing peptidase (MAS1). SMF1 overexpression as well as addition of 1 mM Mn2+ to the growth medium complemented this mutation. This also suggests that in vivo Mas1p is a manganese-dependent peptidase. The yeast Smf1p resembles a protein from Drosophila and mammalian macrophages. The latter was implicated in conferring resistance to mycobacteria. A connection between Mn2+ transport and resistance or sensitivity to mycobacteria is discussed.

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Molecular approaches for increasing the micronutrient density in edible portions of food crops
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Authors: Supek, F., Supekova, L., Nelson, H., & Nelson, N.
Affiliations: Roche Institute of Molecular Biology, Nutley, NJ 07110, USA.
ORCID: Nelson, H
Nelson, N
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1996-05-14
Volume: 93
Issue: 10
Pages: 5105-5110
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.93.10.5105
PMC: PMC39414
OpenAlex: W2015326313
Cited by: 325
References: 41
Citations by year: 2026: 1 · 2024: 4 · 2023: 7 · 2022: 10 · 2021: 11 · 2020: 9 · 2019: 8 · 2018: 6 · 2017: 8 · 2016: 3 · 2015: 10 · 2014: 9 · 2013: 5 · 2012: 5
FWCI: 10.74
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: manganese transporter, manganese deficiency, plasma membrane proteins, mitochondrial processing peptidase, Mas receptor, extragenic suppressors, Saccharomyces cerevisiae mutants
MeSH terms: Mitochondrial Processing Peptidase, Amino Acid Sequence, Animals, Biological Transport, Active, Carrier Proteins, Fungal Proteins, Genes, Fungal, Genetic Complementation Test, Macrophages, Manganese, Membrane Proteins, Metalloendopeptidases, Molecular Sequence Data, Mycobacterium, Phenotype, Saccharomyces cerevisiae, Point Mutation

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A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria.

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