The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Apoptosis and APC in colorectal tumorigenesis.
Open accessAbstract
Tumors result from disruptions in the homeostatic mechanisms that regulate cell birth and cell death. In colon cancer, one of the earliest manifestation of this imbalance is the formation of polyps, caused by somatic and inherited mutations of the adenomatous polyposis coli (APC) tumor suppressor gene in both humans and mice. While the importance of APC in tumorigenesis is well documented, how it functions to prevent tumors remains a mystery. Using a novel inducible expression system, we show that expression of APC in human colorectal cancer cells containing endogenous inactive APC alleles results in a substantial diminution of cell growth. Further evaluation demonstrated that this was due to the induction of cell death through apoptosis. These results suggest that apoptosis plays a role not only in advanced tumors but also at the very earliest stages of neoplasia.
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Cites
Identification and characterization of the familial adenomatous polyposis coli gene
Groden, J., Thliveris, A., Samowitz, W., Carlson, M., Gelbert, L., Albertsen, H., Joslyn, G., Stevens, J., Spirio, L., Robertson, M., et al. (1991) · Cell · doi:10.1016/0092-8674(81)90021-0 · Cited by 2,796
Identification of FAP Locus Genes from Chromosome 5q21
Kinzler, K. W., Nilbert, M. C., Su, L.-K., Vogelstein, B., Bryan, T. M., Levy, D. B., Smith, K. J., Preisinger, A. C., Hedge, P., McKechnie, D., et al. (1991) · Science · doi:10.1126/science.1651562 · Cited by 2,355
Self-citationHypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
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Tsujii, M., & DuBois, R. N. (1995) · Cell · doi:10.1016/0092-8674(95)90127-2 · Cited by 2,267
APC mutations occur early during colorectal tumorigenesis
Powell, S. M., Zilz, N., Beazer-Barclay, Y., Bryan, T. M., Hamilton, S. R., Thibodeau, S. N., Vogelstein, B., & Kinzler, K. W. (1992) · Nature · doi:10.1038/359235a0 · Cited by 1,924
Self-citationMutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients
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Self-citationTreatment of Colonic and Rectal Adenomas with Sulindac in Familial Adenomatous Polyposis
Giardiello, F. M., Hamilton, S. R., Krush, A. J., Piantadosi, S., Hylind, L. M., Celano, P., Booker, S. V., Robinson, C. R., & Offerhaus, G. J. A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305063281805 · Cited by 1,717
Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene
Su, L.-K., Kinzler, K. W., Vogelstein, B., Preisinger, A. C., Moser, A. R., Luongo, C., Gould, K. A., & Dove, W. F. (1992) · Science · doi:10.1126/science.1350108 · Cited by 1,536
Self-citationOzawa, M., Baribault, H., & Kemler, R. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03563.x · Cited by 1,396
Association of the APC Gene Product with β-Catenin
Rubinfeld, B., Souza, B., Albert, I., Müller, O., Chamberlain, S. H., Masiarz, F. R., Munemitsu, S., & Polakis, P. (1993) · Science · doi:10.1126/science.8259518 · Cited by 1,223
Cited by
Lessons from hereditary colorectal cancer
Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919
Self-citationIdentification of c- MYC as a Target of the APC Pathway
He, T.-C., Sparks, A. B., Rago, C., Hermeking, H., Zawel, L., da Costa, L. T., Morin, P. J., Vogelstein, B., & Kinzler, K. W. (1998) · Science · doi:10.1126/science.281.5382.1509 · Cited by 4,566
Self-citationConstitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma
Korinek, V., Barker, N., Morin, P. J., van Wichen, D., de Weger, R., Kinzler, K. W., Vogelstein, B., & Clevers, H. (1997) · Science · doi:10.1126/science.275.5307.1784 · Cited by 2,905
Self-citationPPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs
He, T.-C., Chan, T. A., Vogelstein, B., & Kinzler, K. W. (1999) · Cell · doi:10.1016/s0092-8674(00)81664-5 · Cited by 1,085
Self-citationPolakis, P. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008052 · Cited by 847
Metadata
- Authors
- Morin, P. J., Vogelstein, B., & Kinzler, K. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-07-23
- Volume
- 93
- Issue
- 15
- Pages
- 7950-7954
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1966121721
- Cited by
- 489
- References
- 43
- FWCI
- 28.44
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Apoptosis and APC in colorectal tumorigenesis. https://app.cochat.ai/papers/10.1073/pnas.93.15.7950
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- Morin, P. J., Vogelstein, B., & Kinzler, K. W. (1996). Apoptosis and APC in colorectal tumorigenesis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.15.7950
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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