The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Identification of FAP Locus Genes from Chromosome 5q21
Abstract
Recent studies suggest that one or more genes on chromosome 5q21 are important for the development of colorectal cancers, particularly those associated with familial adenomatous polyposis (FAP). To facilitate the identification of genes from this locus, a portion of the region that is tightly linked to FAP was cloned. Six contiguous stretches of sequence (contigs) containing approximately 5.5 Mb of DNA were isolated. Subclones from these contigs were used to identify and position six genes, all of which were expressed in normal colonic mucosa. Two of these genes (APC and MCC) are likely to contribute to colorectal tumorigenesis. The MCC gene had previously been identified by virtue of its mutation in human colorectal tumors. The APC gene was identified in a contig initiated from the MCC gene and was found to encode an unusually large protein. These two closely spaced genes encode proteins predicted to contain coiled-coil regions. Both genes were also expressed in a wide variety of tissues. Further studies of MCC and APC and their potential interaction should prove useful for understanding colorectal neoplasia.
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Basic local alignment search tool
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Self-citationPredicting coiled coils from protein sequences.
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The GTPase superfamily: conserved structure and molecular mechanism
Bourne, H. R., Sanders, D. A., & McCormick, F. (1991) · Nature · doi:10.1038/349117a0 · Cited by 3,392
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Metadata
- Authors
- Kinzler, K. W., Nilbert, M. C., Su, L.-K., Vogelstein, B., Bryan, T. M., Levy, D. B., Smith, K. J., Preisinger, A. C., Hedge, P., McKechnie, D., Finniear, R., Markham, A., Groffen, J., Boguski, M. S., Altschul, S. F., Horii, A., Ando, H., Miyoshi, Y., Miki, Y., Nishisho, I., & Nakamura, Y.
- Venue
- Science
- Published
- 1991-08-09
- Volume
- 253
- Issue
- 5020
- Pages
- 661-665
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2059813946
- Cited by
- 2,355
- References
- 3
- FWCI
- 118.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kinzler, K. W., Nilbert, M. C., Su, L.-K., Vogelstein, B., Bryan, T. M., Levy, D. B., Smith, K. J., Preisinger, A. C., Hedge, P., McKechnie, D., Finniear, R., Markham, A., Groffen, J., Boguski, M. S., Altschul, S. F., Horii, A., Ando, H., Miyoshi, Y., Miki, Y., . . . Nakamura, Y. (1991). Identification of FAP Locus Genes from Chromosome 5q21. Science. https://doi.org/10.1126/science.1651562
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