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Light-directed synthesis of high-density oligonucleotide arrays using semiconductor photoresists
Open accessAbstract
High-density arrays of oligonucleotide probes are proving to be powerful new tools for large-scale DNA and RNA sequence analysis. A method for constructing these arrays, using light-directed DNA synthesis with photoactivatable monomers, can currently achieve densities on the order of 10 6 sequences/cm 2 . One of the challenges facing this technology is to further increase the volume, complexity, and density of sequence information encoded in these arrays. Here we demonstrate a new approach for synthesizing DNA probe arrays that combines standard solid-phase oligonucleotide synthesis with polymeric photoresist films serving as the photoimageable component. This opens the way to exploiting high-resolution imaging materials and processes from the microelectronics industry for the fabrication of DNA probe arrays with substantially higher densities than are currently available.
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Citations
Cited by
Designing materials for biology and medicine
Langer, R., & Tirrell, D. A. (2004) · Nature · doi:10.1038/nature02388 · Cited by 3,198
The Efficiency of Light-Directed Synthesis of DNA Arrays on Glass Substrates
McGall, G. H., Barone, A. D., Diggelmann, M., Fodor, S. P. A., Gentalen, E., & Ngo, N. (1997) · Journal of the American Chemical Society · doi:10.1021/ja964427a · Cited by 282
Self-citationPhotoelectrochemical synthesis of DNA microarrays
Chow, B. Y., Emig, C. J., & Jacobson, J. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813011106 · Cited by 48
Photolithographic synthesis of high-density DNA probe arrays: Challenges and opportunities
Pawloski, A. R., McGall, G., Kuimelis, R. G., Barone, D., Cuppoletti, A., Ciccolella, P., Spence, E., Afroz, F., Bury, P., Chen, C., et al. (2007) · Journal of Vacuum Science & Technology B: Microelectronics and Nanometer Structures Processing, Measurement, and Phenomena · doi:10.1116/1.2794325 · Cited by 15
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Metadata
- Authors
- McGall, G., Labadie, J., Brock, P., Wallraff, G., Nguyen, T., & Hinsberg, W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-11-26
- Volume
- 93
- Issue
- 24
- Pages
- 13555-13560
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2012878989
- Cited by
- 246
- References
- 0
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- green
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- McGall, G., Labadie, J., Brock, P., Wallraff, G., Nguyen, T., & Hinsberg, W. (1996). Light-directed synthesis of high-density oligonucleotide arrays using semiconductor photoresists. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.24.13555
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