The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy
Open accessAbstract
Sustained hyperleptinemia of 8 ng/ml was induced for 28 days in normal Wistar rats by infusing a recombinant adenovirus containing the rat leptin cDNA (AdCMV-leptin). Hyperleptinemic rats exhibited a 30–50% reduction in food intake and gained only 22 g over the experimental period versus 115–132 g in control animals that received saline infusions or a recombinant virus containing the β-galactosidase gene (AdCMV-βGal). Body fat was absent in hyperleptinemic rats, whereas control rats pair-fed to the hyperleptinemic rats retained ≈50% body fat. Further, plasma triglycerides and insulin levels were significantly lower in hyperleptinemic versus pair-fed controls, while fatty acid and glucose levels were similar in the two groups, suggestive of enhanced insulin sensitivity in the hyperleptinemic animals. Thus, despite equivalent reductions in food intake and weight gain in hyperleptinemic and pair-fed animals, identifiable fat tissue was completely ablated only in the former group, raising the possibility of a specific lipoatrophic activity for leptin.
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Cites
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Cited by
Leptin and the regulation of body weight in mammals
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Congenital leptin deficiency is associated with severe early-onset obesity in humans
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Adipose tissue as a buffer for daily lipid flux
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Metadata
- Authors
- Chen, G., Koyama, K., Yuan, X., Lee, Y., Zhou, Y.-T., O’Doherty, R., Newgard, C. B., & Unger, R. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-12-10
- Volume
- 93
- Issue
- 25
- Pages
- 14795-14799
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2020971663
- Cited by
- 318
- References
- 20
- FWCI
- 8.91
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy. https://app.cochat.ai/papers/10.1073/pnas.93.25.14795
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- Chen, G., Koyama, K., Yuan, X., Lee, Y., Zhou, Y.-T., O’Doherty, R., Newgard, C. B., & Unger, R. H. (1996). Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.25.14795
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
