The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits
Open accessAbstract
Fragile X syndrome arises from blocked expression of the fragile X mental retardation protein (FMRP). Golgi-impregnated mature cerebral cortex from fragile X patients exhibits long, thin, tortuous postsynaptic spines resembling spines observed during normal early neocortical development. Here we describe dendritic spines in Golgi-impregnated cerebral cortex of transgenic fragile X gene ( Fmr1 ) knockout mice that lack expression of the protein. Dendritic spines on apical dendrites of layer V pyramidal cells in occipital cortex of fragile X knockout mice were longer than those in wild-type mice and were often thin and tortuous, paralleling the human syndrome and suggesting that FMRP expression is required for normal spine morphological development. Moreover, spine density along the apical dendrite was greater in the knockout mice, which may reflect impaired developmental organizational processes of synapse stabilization and elimination or pruning.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These effects, together with spine elongation, suggests a phenotype of reduced or delayed synapse maturation that is reminiscent of the phenotypes observed in mouse models of fragile X syndrome (Comery et al., 1997; Irwin et al., 2001), Rett syndrome (Armstrong, 2005; Belichenko et al., 2009; Chao et al., 2007), and Angelman syndrome (Dindot et al., 2008; Sato and Stryker, 2010; Yashiro et al., 2”
From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Comery et al., 1997
In the citing paper
“The increased spine length and density observed in human postmortem studies were replicated in Fmr1 KO mice [74, 167–169], although differences were noted dependent on age and brain area.”
From Autism spectrum disorder: neuropathology and animal models (2017) · cites this paper as [74]
In the citing paper
“Absence of FMRP in both humans and mice results in improper development of dendritic spines on cortical pyramidal neurons (Comery et al., 1997; Irwin et al., 2000; Irwin et al., 2001; Irwin et al., 2002).”
From Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders (2014) · cites this paper as Comery et al., 1997
In the citing paper
“In a mouse model of Fragile X syndrome, spines are more numerous, and a higher percentage of them appear immature upon examination of adult fixed tissues (Comery et al., 1997; Irwin et al., 2000).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Comery et al., 1997
In the citing paper
“In a mouse model of Fragile X syndrome, spines are more numerous, and a higher percentage of them appear immature upon examination of adult fixed tissues (Comery et al., 1997; Irwin et al., 2000).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Comery et al., 1997
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Verkerk, A. J. M. H., Pieretti, M., Sutcliffe, J. S., Fu, Y.-H., Kuhl, D. P. A., Pizzuti, A., Reiner, O., Richards, S., Victoria, M. F., Zhang, F., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90397-h · Cited by 3,481
Self-citationThe development of ocular dominance columns in normal and visually deprived monkeys
Le Vay, S., Wiesel, T. N., & Hubel, D. H. (1980) · Journal of Comparative Neurology · doi:10.1002/cne.901910102 · Cited by 1,123
Fmr1 knockout mice: A model to study fragile X mental retardation
THEDUTCHBELGIANFRAGILEXCONSOR (1994) · Cell · doi:10.1016/0092-8674(94)90569-x · Cited by 1,108
Devys, D., Lutz, Y., Rouyer, N., Bellocq, J., & Mandel, J. (1993) · Nature Genetics · doi:10.1038/ng0893-335 · Cited by 781
FMR1 Protein: Conserved RNP Family Domains and Selective RNA Binding
Ashley, C. T., Wilkinson, K. D., Reines, D., & Warren, S. T. (1993) · Science · doi:10.1126/science.7692601 · Cited by 752
Weiler, I. J., Irwin, S. A., Klintsova, A. Y., Spencer, C. M., Brazelton, A. D., Miyashiro, K., Comery, T. A., Patel, B., Eberwine, J., & Greenough, W. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5395 · Cited by 644
Self-citationThe protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein.
Siomi, H., Siomi, M. C., Nussbaum, R. L., & Dreyfuss, G. (1993) · Cell · doi:10.1016/0092-8674(93)90420-u · Cited by 641
A point mutation in the FMR-1 gene associated with fragile X mental retardation
Boulle, K. D., Verkerk, A. J. M. H., Reyniers, E., Vits, L., Hendrickx, J., Roy, B. V., Bos, F. V. D., de Graaff, E., Oostra, B. A., & Willems, P. J. (1993) · Nature Genetics · doi:10.1038/ng0193-31 · Cited by 624
Self-citation(1994) · PubMed · Cited by 565
Analysis of neocortex in three males with the Fragile X syndrome
Hinton, V. J., Brown, W. T., Wisniewski, K., & Rudelli, R. D. (1991) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320410306 · Cited by 527
Research works printed but not linked: 4
- W T Brown Am J Hum Genet 58, 903–905 (1996).
- Cell 78, 23–33 (1994).
- C H Horner, E Arbuthnott J Anat 177, 179–184 (1991).
- D P Purpura Adv Neurol 12, 91–134 (1975).
Cited by
Sorted by citations
Items 801–900 of 1,000
From Discovery to Innovative Translational Approaches in 80 Years of Fragile X Syndrome Research
van der Lei, M. B., & Kooy, R. F. (2025) · Biomedicines · doi:10.3390/biomedicines13040805 · Cited by 6
Impaired synaptosome phagocytosis in macrophages of individuals with autism spectrum disorder
Nishi, Y., Toritsuka, M., Takada, R., Ishikawa, M., Ishida, R., Kayashima, Y., Yamauchi, T., Okumura, K., Takeda, T., Yamamuro, K., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03002-3 · Cited by 10
Perera-Murcia, G. R., Prior-González, M., Gutiérrez-Vera, B., López-Huerta, V. G., Cecilia, G.-M., Contreras-López, R., Tenorio-Hernández, L., & Cortés, Y. R. (2026) · Journal of Neuroscience · doi:10.1523/jneurosci.0791-25.2025 · Cited by 6
The role of brain-derived neurotrophic factor in neural circuit development and function
Autry, A. E., & Bambah-Mukku, D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-823672-7.00020-x · Cited by 6
Zeitouny, C., Körte, M., & Michaelsen‐Preusse, K. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106240 · Cited by 7
Molecular medicine of fragile X syndrome: based on known molecular mechanisms
Luo, S.-Y., Wu, L., & Duan, R. (2015) · World Journal of Pediatrics · doi:10.1007/s12519-015-0052-0 · Cited by 8
Modelling Autistic Neurons with Induced Pluripotent Stem Cells
Kathuria, A., Sala, C., Verpelli, C., & Price, J. (2017) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-319-52498-6_3 · Cited by 6
Linking Genes to Cognition: The Case of Fragile X Syndrome
Cornish, K. M., Bertone, A., Kogan, C. S., & Scerif, G. (2012) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780195305012.013.0004 · Cited by 6
Kulkarni, A., Lopez, D. H., & Extavour, C. G. M. (2020) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2020.00215 · Cited by 8
The Use of Peptides in the Treatment of Fragile X Syndrome: Challenges and Opportunities
Romagnoli, A., & Marino, D. D. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.754485 · Cited by 9
Animal Models of Fragile X Syndrome: Mice and Flies
Oostra, B. A., & Nelson, D. L. (2006) · Elsevier eBooks · doi:10.1016/b978-012369462-1/50012-0 · Cited by 6
Self-citationNeocortical vasculature abnormalities in the Fragile X mental retardation syndrome
Galvan, A. M., & Galvez, R. (2012) · Brain Research · doi:10.1016/j.brainres.2012.06.056 · Cited by 6
Modeling Features of Autism in Animals
Patterson, P. H. (2006) · CRC Press eBooks · doi:10.1201/9781420004205-18 · Cited by 6
Epidemiology of mental retardation in children
Murphy, C. C., Boyle, C. A., Schendel, D., Decouflé, P., & Yeargin‐Allsopp, M. (1998) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/(sici)1098-2779(1998)4:1 · Cited by 79
Activity of Human-Specific Interlaminar Astrocytes in a Chimeric Mouse Model of Fragile X Syndrome
Anding, A., Ren, B., Padmashri, R., Burkovetskaya, M. E., & Dunaevsky, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136510 · Cited by 5
Prasad, S., & Singh, K. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9545-0 · Cited by 5
DeMarco, E. C., Stoner, G., & Robles, E. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049507 · Cited by 6
Synaptopodin: a key regulator of Hebbian plasticity
Wu, P. Y., Inglebert, Y., & McKinney, R. A. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1482844 · Cited by 7
Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autism
Bridi, M., Luo, N., Kim, G., Menarchek, B. J., Lee, R. A., Rodríguez, B. A., Severín, D., Moreno, C., Contreras, A., Wesselborg, C., et al. (2024) · iScience · doi:10.1016/j.isci.2024.111494 · Cited by 6
Sontheimer, H. W. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821228-8.00014-7 · Cited by 5
Talvio, K., Minkeviciene, R., Townsley, K. G., Achuta, V. S., Huckins, L. M., Corcoran, P., Brennand, K. J., & Castrén, M. L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1034679 · Cited by 5
Gredell, M., Lu, J., & Zuo, Y. (2023) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2023.1135479 · Cited by 5
The Role of MicroRNAs in Neurodegenerative Diseases: Implications for Early Detection and Treatment
Majer, A., Boese, A. S., & Booth, S. A. (2011) · Springer eBooks · doi:10.1007/978-3-642-22517-8_18 · Cited by 5
FMRP Regulates Neurogenesis In Vivo in Xenopus laevis Tadpoles
Faulkner, R. L., Wishard, T. J., Thompson, C. K., Liu, H.-H., & Cline, H. T. (2015) · eNeuro · doi:10.1523/eneuro.0055-14.2015 · Cited by 5
Human Pluripotent Stem Cells in Modeling Human Disorders: the Case of Fragile X Syndrome
Vershkov, D., & Benvenisty, N. (2016) · Regenerative Medicine · doi:10.2217/rme-2016-0100 · Cited by 6
GABAergic Progenitor Cell Graft Rescues Cognitive Deficits in Fragile X Syndrome Mice
Wang, C., Liu, J., Su, L., Wang, X., Bian, Y., Wang, Z., Ye, L., Lu, X., Zhou, L., Chen, W., et al. (2025) · Advanced Science · doi:10.1002/advs.202411972 · Cited by 4
Ciranna, L., & Costa, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062495 · Cited by 5
Autism and Schizophrenia Are Disorders of Evolvability
Gualtieri, C. T. (2014) · Open Journal of Medical Psychology · doi:10.4236/ojmp.2014.32019 · Cited by 4
PAK1 inhibition with Romidepsin attenuates H‐reflex hyperexcitability after spinal cord injury
Kauer, S. D., Benson, C. A., Carrara, J., Tarafder, A. A., Ibrahim, Y. H., Estacion, M. A., Waxman, S. G., & Tan, A. M. (2024) · The Journal of Physiology · doi:10.1113/jp284976 · Cited by 4
Felix-López, X. A., Argüello-García, R., Cerda-Flores, R. M., Peñaloza-Espinoza, R. I., Buentello‐Malo, L., Estrada-Mena, F. J., Ramos-Kuri, M., Gómez, F. S., & Arenas-Aranda, D. J. (2006) · Human Biology · doi:10.1353/hub.2007.0004 · Cited by 4
Limaye, A. M., Asangani, I. A., Bora, N., & Kondaiah, P. (2007) · Asian Journal of Andrology · doi:10.1111/j.1745-7262.2007.00293.x · Cited by 4
Lau, B. W.-M., Yau, S., Po, K.-T., & So, K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801977-1.00011-8 · Cited by 5
Modeling Fragile X Syndrome Using Human Pluripotent Stem Cells
Vershkov, D., Ben‐Hur, T., & Benvenisty, N. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804461-2.00006-8 · Cited by 4
Fragile X mental retardation: Misregulation of protein synthesis in the developing brain?
Feng, Y. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10063 · Cited by 4
Anagnostopoulos, A. V., & Scharpf, R. B. (1998) · Trends in Genetics · doi:10.1016/s0168-9525(98)01395-x · Cited by 4
The fragile X syndrome: bridging the gap from gene to behavior
D, S. E. M., & Feinstein, C. (2001) · Current Opinion in Psychiatry · doi:10.1097/00001504-200109000-00004 · Cited by 4
9th International workshop on Fragile X syndrome and X-linked mental retardation
Fryns, J., Borghgraef, M., Brown, T. W., Chelly, J., Fisch, G. S., Hamel, B. C. J., Hanauer, A., Lacombe, D., Luo, L., Macpherson, J., et al. (2000) · American Journal of Medical Genetics · doi:10.1002/1096-8628(20001023)94:5 · Cited by 9
Delayed Development of Dendritic Spines in Fxr2 Knockout Mouse
Deng, J., & Dunaevsky, A. (2014) · The Open Neuroscience Journal · doi:10.2174/1874082000903010148 · Cited by 3
Subramanian, M. P., Mills, W. T., Paranjpe, M. D., Onuchukwu, U. S., Inamdar, M., Maytin, A. R., Li, X., Pomerantz, J. L., & Meffert, M. K. (2023) · iScience · doi:10.1016/j.isci.2023.108676 · Cited by 3
New Innovations: Therapies for Genetic Conditions
Rajabi, F., & Picker, J. D. (2014) · Current Genetic Medicine Reports · doi:10.1007/s40142-014-0043-9 · Cited by 4
Nakayama, Y., Adachi, K., Shioda, N., Maeta, S., Nanba, E., & Kugoh, H. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112419 · Cited by 4
Li, H., & Gavis, E. R. (2022) · Development · doi:10.1242/dev.200379 · Cited by 3
Bai, S.-Y., Zeng, D.-Y., Ouyang, M., Zeng, Y., Tan, W., & Xu, L. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1393536 · Cited by 2
Robinson, C. M., Patel, M. R., & Webb, D. J. (2016) · F1000Research · doi:10.12688/f1000research.8649.1 · Cited by 4
Steward, O., Wallace, C. S., & Worley, P. F. (2001) · International review of neurobiology · doi:10.1016/s0074-7742(01)45015-x · Cited by 3
Cytoskeletal Determinants of Dendritic Development and Function: Implications for Mental Retardation
Kaufmann, W. E. (1999) · Developmental Neuropsychology · doi:10.1207/s15326942dn1603_11 · Cited by 3
Ataxie cérébelleuse tardive due à la prémutation de l’X fragile
Chaussenot, A., Borg, M., Bayreuther, C., & Lebrun‐Frénay, C. (2008) · Revue Neurologique · doi:10.1016/j.neurol.2008.03.022 · Cited by 3
Galvez, R., Nicholson, D. A., & Disterhoft, J. F. (2011) · Developmental Psychobiology · doi:10.1002/dev.20554 · Cited by 3
Amygdala – and serum – neurotrophic factor levels depend on rearing condition in male rats
Babri, S., Mohaddes, G., & Mosaferi, B. (2018) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174418000144 · Cited by 3
Hoffmann, A., & Berry‐Kravis, E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800109-7.00020-0 · Cited by 3
Genetics of mental retardation
Anisimova, I. V. (2021) · Nauchno-prakticheskii zhurnal «Medicinskaia genetika» · doi:10.25557/2073-7998.2021.02.3-20 · Cited by 3
Isolation of mouse neuritic mRNAs
Reis, S. A., Oostra, B. A., & Willemsen, R. (2006) · Journal of Molecular Histology · doi:10.1007/s10735-006-9036-7 · Cited by 3
Self-citationThe Origins of Behavior and Cognition in the Developing Brain
Black, J., Jennings, V. L., Aldridge, G. M., & Greenough, W. T. (2008) · Elsevier eBooks · doi:10.1016/b978-0-323-04025-9.50007-6 · Cited by 4
Self-citationKhandjian, É. W., Robert, C., Khalfallah, O., & Davidovic, L. (2017) · Wiley eBooks · doi:10.1002/9780470015902.a0005533.pub2 · Cited by 3
Fragile X-Linked Mental Retardation
Gantois, I., Kooy, R. F., & Oostra, B. A. (2006) · Wiley-VCH eBooks · doi:10.1002/3527600906.mcb.200300051 · Cited by 3
Self-citationImplications of RNA ‐binding Proteins for Human Diseases
Lukong, K. E., & Fatimy, R. E. (2012) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0023866 · Cited by 3
The Role of the Postsynaptic Density and the Spine Cytoskeleton in Synaptic Plasticity
Marcora, E. M., Carlisle, H. J., & Kennedy, M. B. (2008) · Elsevier eBooks · doi:10.1016/b978-012370509-9.00036-x · Cited by 4
Fragile X syndrome: new developments
Harris, S. W., & Hagerman, R. J. (1999) · Current Opinion in Psychiatry · doi:10.1097/00001504-199909000-00008 · Cited by 3
Diagnóstico y recomendaciones para la atención de calidad a la primera infancia en ColombiaPreprint
Bernal, R. (2014) · RePEc: Research Papers in Economics · Cited by 3
Autistic behavior is a common outcome of biallelic disruption of PDZD8 in humans and mice
Pantiru, A., de Sompele, S. V., Ligneul, C., Chatelain, C., Barrea, C., Lerch, J. P., Filippi, B., Alkan, S., Baere, E. B. W. D., Johnston, J., et al. (2025) · Molecular Autism · doi:10.1186/s13229-025-00650-8 · Cited by 4
O’Leary, H., & Benke, T. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804066-9.00074-2 · Cited by 2
Development and Developmental Disorders of the Cerebral Cortex
ten Donkelaar, H. J., Vasung, L., Molnár, Z., Aronica, E., Lammens, M. M. Y., van Bokhoven, H., Ulzen, K. K.-V., & Hori, A. (2023) · Springer eBooks · doi:10.1007/978-3-031-26098-8_10 · Cited by 3
How dendritic spines shape is determined by MMP-9 activity in FXS
Dziembowska, M. (2023) · International review of neurobiology · doi:10.1016/bs.irn.2023.10.001 · Cited by 2
avances en neurociencia.: sinaptogénesis y aprendizaje del movimiento.
Merlo, L. M. (2006) · Cited by 2
Fragile X—A Family of Disorders: Changing Phenotype and Molecular Genetics
Spector, E. (2012) · Springer eBooks · doi:10.1007/978-1-4419-1688-4_19 · Cited by 2
Withers, G. S., Wallace, C. S., Gibbs, E. M., Emery, I. R., & Applegate, M. L. (2011) · Developmental Psychobiology · doi:10.1002/dev.20560 · Cited by 2
Martin, B. S., & Huntsman, M. M. (2014) · The Receptors · doi:10.1007/978-1-4939-1426-5_13 · Cited by 2
The Chronic Exercise–Cognition Interaction and Parkinson Disease
Hackney, M. E., Nocera, J. R., Bowers, D., Altmann, L. J. P., & Hass, C. J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800778-5.00015-3 · Cited by 2
Löhmann, C. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397266-8.00140-x · Cited by 2
Defects in Rho GTPase Signaling to the Spine Actin Cytoskeleton in FMR1 Knockout Mice
Lauterborn, J. C., & Gall, C. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804461-2.00014-7 · Cited by 2
Supersizing Intelligence: How the Collective Mind Builds on Dual Networks
Checkley, M. S., & Galindo, M. F. A. (2018) · Strategic Change · doi:10.1002/jsc.2202 · Cited by 2
Zebrafish as a Model to study Human Disease: Functional Studies of the FXR Proteins
Padje, S. V. ‘. (2007) · Cited by 2
Matrix Metalloproteinases in Fragile X Syndrome
Ethell, D. W., & Sidhu, H. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804461-2.00015-9 · Cited by 2
Automated detection and time lapse analysis of dendritic spines in laser scanning microscopy images
Cheng, J. (2009) · Digital Repository Service (Northeastern University) · doi:10.17760/d10019303 · Cited by 2
Kuchenbecker, K. (2006) · Cited by 2
The RNA Binding Protein FMRP Promotes Myelin Sheath GrowthPreprint
Doll, C. A., Yergert, K. M., & Appel, B. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/669895 · Cited by 2
Opto-CLIP reveals dynamic FMRP regulation of mRNAs upon CA1 neuronal activationPreprint
Singer, R. A., Rajchin, V., Park, K., Heintz, N., & Darnell, R. B. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.13.607210 · Cited by 2
A Transcriptomic Dataset of Embryonic Murine Telencephalon of Fmr1-Deficient Mice
Ebrahimiazar, S., Kikkawa, T., Minakuchi, Y., Miyashita, S., Manabe, S., Hoshino, M., Toyoda, A., & Osumi, N. (2025) · Scientific Data · doi:10.1038/s41597-025-05104-7 · Cited by 2
Homeostasis of dendritic spines in hippocampal CA1 cells
Mestrallet, C. A. (2011) · UCL Discovery (University College London) · Cited by 2
Moppert, S., & Mercado, E. (2024) · Developmental Psychobiology · doi:10.1002/dev.22504 · Cited by 1
Smith, E. G., Dominick, K. C., Schmitt, L., Pedapati, E. V., & Erickson, C. A. (2024) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-024-09582-5 · Cited by 1
Disrupted theta synchronization and synaptic connectivity in the visual cortex of Fmr1 KO mice
Cheng, X., Nareddula, S., Gao, H.-C., Chen, Y., Xiao, T., Nadew, Y. Y., Xu, F., Edens, P. A., Saldarriaga, V., Hu, X., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-65665-4 · Cited by 2
Goel, A., Razak, K. A., Chubykin, A. A., & Antoine, M. W. (2025) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-025-09634-4 · Cited by 1
Diacylglycerol kinases: Molecular mechanism of cellular and physiological functions
Kimura, T., & Epand, R. M. (2026) · Progress in Lipid Research · doi:10.1016/j.plipres.2025.101373 · Cited by 2
mRNA Translation and Proteasomal Degradation in Health and Neurological Disease
Isaac, A. R., Cozachenco, D., Wagner, B. D. A., Chauvet, M. G., & Lourenco, M. V. (2026) · Physiology · doi:10.1152/physiol.00023.2025 · Cited by 1
HK2 drives synaptic dysfunction in fragile X syndrome via epigenetic regulation of H3K18 lactylation
Luan, Y., Zhang, H., Ma, N., Zhang, Y., Xu, Z., Zhang, W., Zhang, X., & Liu, Y. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1903604 · Cited by 1
Translational Control of Synaptic Plasticity and Memory
Khoutorsky, A., Gkogkas, C. G., & Sonenberg, N. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3991-2_14 · Cited by 1
Spine Morphology and Plasticity in X-linked Mental Retardations
Arikkath, J. (2014) · The Open Neuroscience Journal · doi:10.2174/1874082000903010134 · Cited by 1
Path to understanding the pathophysiology of Fragile X syndrome
Mulle, J. G., Peñagarikano, O., & Warren, S. T. (2007) · Future Neurology · doi:10.2217/14796708.2.5.567 · Cited by 1
Phase II and III drugs for the treatment of fragile X syndrome
Politte, L. C., & McDougle, C. J. (2012) · Expert Opinion on Orphan Drugs · doi:10.1080/21678707.2013.750240 · Cited by 1
Translational Neuroimaging for Drug Discovery and Development in Autism Spectrum Disorders
Badura, L. L., Saxe, M., Risterucci, C., Brammer, M. J., McTighe, S. M., Ring, R. H., & Smith, D. G. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-386945-6.00009-3 · Cited by 1
Fragile X Mental Retardation Syndrome
Steinbach, P. (2005) · Springer eBooks · doi:10.1007/3-540-29623-9_2540 · Cited by 1
Maeda, K., Tanimura, M., Masago, Y., Horiyama, T., Takemoto, H., Sasaki, T., Koyama, R., Ikegaya, Y., & Ogawa, K. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1455812 · Cited by 1
Haynes, R. L., Kinney, H. C., & Volpe, J. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-10513-5.00007-3 · Cited by 1
Neuroanatomical Considerations Specific to the Study of Neurogenetics
Galaburda, A. M., & Schmitt, J. E. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-353-8_2 · Cited by 5
Costa, R. M., Elgersma, Y., & Silva, A. J. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-353-8_3 · Cited by 3
Prevalence Studies on Fragile X Alleles in Autism
Rodríguez‐Revenga, L., Madrigal, I., & Milà, M. (2013) · Springer eBooks · doi:10.1007/978-1-4614-4788-7_185 · Cited by 1
Regulation of dendritic spine morphogenesis and synapse formation by copines
Galic, M. (2006) · edoc (University of Basel) · doi:10.5451/unibas-004198769 · Cited by 1
Gelsolin : a regulator of postsynaptic actin assembly and AMPA receptor expression
Zhao, P. (2003) · edoc (University of Basel) · doi:10.5451/unibas-003354194 · Cited by 1
Mouse Models of Triplet Repeat Diseases
Bates, G. P., & Hay, D. (2004) · Humana Press eBooks · doi:10.1385/1-59259-804-8:003 · Cited by 1
Metadata
- Authors
- Comery, T. A., Harris, J. B., Willems, P. J., Oostra, B. A., Irwin, S. A., Weiler, I. J., & Greenough, W. T.
- Affiliations
- University of Antwerp (BE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1997-05-13
- Volume
- 94
- Issue
- 10
- Pages
- 5401-5404
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC24690
- OpenAlex
- W2022959185
- Cited by
- 1,046
- References
- 30
- Citations by year
- 2026: 15 · 2025: 14 · 2024: 28 · 2023: 20 · 2022: 35 · 2021: 24 · 2020: 34 · 2019: 38 · 2018: 35 · 2017: 52 · 2016: 41 · 2015: 45 · 2014: 64 · 2013: 57 · 2012: 43
- FWCI
- 14.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Funders
- FRAXA Research Foundation (MH35321)
- John D. and Catherine T. MacArthur Foundation
- National Institute of Mental Health (MH-35321, R01MH035321, R37MH035321)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- fragile X syndrome, FMRP, Fmr1 knockout mice, dendritic spines, dendritic spine morphology, synaptic pruning, synapse stabilization, layer 5 pyramidal neurons, occipital cortex, Golgi impregnation, postsynaptic spines
- MeSH terms
- Animals, Cerebral Cortex, Dendrites, Female, Fragile X Syndrome, Golgi Apparatus, Humans, Mice, Inbred Strains, Occipital Lobe, Pyramidal Cells, Mice, Knockout, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
