The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits
Open accessAbstract
Fragile X syndrome arises from blocked expression of the fragile X mental retardation protein (FMRP). Golgi-impregnated mature cerebral cortex from fragile X patients exhibits long, thin, tortuous postsynaptic spines resembling spines observed during normal early neocortical development. Here we describe dendritic spines in Golgi-impregnated cerebral cortex of transgenic fragile X gene ( Fmr1 ) knockout mice that lack expression of the protein. Dendritic spines on apical dendrites of layer V pyramidal cells in occipital cortex of fragile X knockout mice were longer than those in wild-type mice and were often thin and tortuous, paralleling the human syndrome and suggesting that FMRP expression is required for normal spine morphological development. Moreover, spine density along the apical dendrite was greater in the knockout mice, which may reflect impaired developmental organizational processes of synapse stabilization and elimination or pruning.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These effects, together with spine elongation, suggests a phenotype of reduced or delayed synapse maturation that is reminiscent of the phenotypes observed in mouse models of fragile X syndrome (Comery et al., 1997; Irwin et al., 2001), Rett syndrome (Armstrong, 2005; Belichenko et al., 2009; Chao et al., 2007), and Angelman syndrome (Dindot et al., 2008; Sato and Stryker, 2010; Yashiro et al., 2”
From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Comery et al., 1997
In the citing paper
“The increased spine length and density observed in human postmortem studies were replicated in Fmr1 KO mice [74, 167–169], although differences were noted dependent on age and brain area.”
From Autism spectrum disorder: neuropathology and animal models (2017) · cites this paper as [74]
In the citing paper
“Absence of FMRP in both humans and mice results in improper development of dendritic spines on cortical pyramidal neurons (Comery et al., 1997; Irwin et al., 2000; Irwin et al., 2001; Irwin et al., 2002).”
From Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders (2014) · cites this paper as Comery et al., 1997
In the citing paper
“In a mouse model of Fragile X syndrome, spines are more numerous, and a higher percentage of them appear immature upon examination of adult fixed tissues (Comery et al., 1997; Irwin et al., 2000).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Comery et al., 1997
In the citing paper
“In a mouse model of Fragile X syndrome, spines are more numerous, and a higher percentage of them appear immature upon examination of adult fixed tissues (Comery et al., 1997; Irwin et al., 2000).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Comery et al., 1997
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Verkerk, A. J. M. H., Pieretti, M., Sutcliffe, J. S., Fu, Y.-H., Kuhl, D. P. A., Pizzuti, A., Reiner, O., Richards, S., Victoria, M. F., Zhang, F., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90397-h · Cited by 3,481
Self-citationThe development of ocular dominance columns in normal and visually deprived monkeys
Le Vay, S., Wiesel, T. N., & Hubel, D. H. (1980) · Journal of Comparative Neurology · doi:10.1002/cne.901910102 · Cited by 1,123
Fmr1 knockout mice: A model to study fragile X mental retardation
THEDUTCHBELGIANFRAGILEXCONSOR (1994) · Cell · doi:10.1016/0092-8674(94)90569-x · Cited by 1,108
Devys, D., Lutz, Y., Rouyer, N., Bellocq, J., & Mandel, J. (1993) · Nature Genetics · doi:10.1038/ng0893-335 · Cited by 781
FMR1 Protein: Conserved RNP Family Domains and Selective RNA Binding
Ashley, C. T., Wilkinson, K. D., Reines, D., & Warren, S. T. (1993) · Science · doi:10.1126/science.7692601 · Cited by 752
Weiler, I. J., Irwin, S. A., Klintsova, A. Y., Spencer, C. M., Brazelton, A. D., Miyashiro, K., Comery, T. A., Patel, B., Eberwine, J., & Greenough, W. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5395 · Cited by 644
Self-citationThe protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein.
Siomi, H., Siomi, M. C., Nussbaum, R. L., & Dreyfuss, G. (1993) · Cell · doi:10.1016/0092-8674(93)90420-u · Cited by 641
A point mutation in the FMR-1 gene associated with fragile X mental retardation
Boulle, K. D., Verkerk, A. J. M. H., Reyniers, E., Vits, L., Hendrickx, J., Roy, B. V., Bos, F. V. D., de Graaff, E., Oostra, B. A., & Willems, P. J. (1993) · Nature Genetics · doi:10.1038/ng0193-31 · Cited by 624
Self-citation(1994) · PubMed · Cited by 565
Analysis of neocortex in three males with the Fragile X syndrome
Hinton, V. J., Brown, W. T., Wisniewski, K., & Rudelli, R. D. (1991) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320410306 · Cited by 527
Flagged first, then by citations
Research works printed but not linked: 4
- W T Brown Am J Hum Genet 58, 903–905 (1996).
- Cell 78, 23–33 (1994).
- C H Horner, E Arbuthnott J Anat 177, 179–184 (1991).
- D P Purpura Adv Neurol 12, 91–134 (1975).
Cited by
Sorted by citations
Items 501–600 of 1,000
The autism diagnosis in translation: shared affect in children and mouse models of ASD
Bishop, S. L., & Lahvis, G. P. (2011) · Autism Research · doi:10.1002/aur.216 · Cited by 40
Newborn, Carrier, and Early Childhood Screening Recommendations for Fragile X
Abrams, L. J., Cronister, A., Brown, W. T., Tassone, F., Sherman, S. L., Finucane, B. M., McConkie‐Rosell, A., Hagerman, R. J., Kaufmann, W. E., Picker, J. D., et al. (2012) · PEDIATRICS · doi:10.1542/peds.2012-0693 · Cited by 48
Scharkowski, F., Frotscher, M., Lutz, D., Körte, M., & Michaelsen‐Preusse, K. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw408 · Cited by 40
Ceolin, L., Bouquier, N., Boubaker-Vitre, J., Rialle, S., Séverac, D., Valjent, E., Perroy, J., & Puighermanal, E. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00340 · Cited by 40
Partial FMRP expression is sufficient to normalize neuronal hyperactivity in Fragile X neurons
Graef, J. D., Wu, H., Ng, C., Sun, C., Villegas, V., Qadir, D., Jesseman, K., Warren, S. T., Jaenisch, R., Cacace, A. M., et al. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14660 · Cited by 42
Abnormal neuronal morphology and neurochemistry in the auditory brainstem of Fmr1 knockout rats.
Ruby, K., Falvey, K., & Kulesza, R. J. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.06.061 · Cited by 41
The role of GABAergic system in neurodevelopmental disorders: a focus on autism and epilepsy.
Sgadó, P., Dunleavy, M., Genovesi, S., Provenzano, G., & Bozzi, Y. (2011) · PubMed Central · Cited by 40
Lepeta, K., Purzycka, K. J., Pachulska‐Wieczorek, K., Mitjans, M., Begemann, M., Vafadari, B., Bijata, K., Adamiak, R. W., Ehrenreich, H., Dziembowska, M., et al. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201707723 · Cited by 39
Alterations of Neocortical Pyramidal Neurons: Turning Points in the Genesis of Mental Retardation
Granato, A., & Giorgio, A. D. (2014) · Frontiers in Pediatrics · doi:10.3389/fped.2014.00086 · Cited by 41
Dendritic spine dysgenesis in neuropathic pain
Tan, A. M., & Waxman, S. G. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.11.024 · Cited by 40
Clemo, H. R., Lomber, S. G., & Meredith, M. A. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu225 · Cited by 45
D’Antoni, S., Lidia de, B. A. R. I., Valenti, D., Borro, M., Bonaccorso, C. M., Simmaco, M., Vacca, R. A., & Catania, M. V. (2019) · Biological Chemistry · doi:10.1515/hsz-2019-0221 · Cited by 42
Lee, K. J., Kim, H., Kim, T. S., Park, S.-H., & Rhyu, I. J. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.01.071 · Cited by 40
Loesch, D. Z., Huggins, R., Bui, M., Taylor, A. K., & Hagerman, R. J. (2002) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.10099 · Cited by 40
Gruss, M. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2003.12.001 · Cited by 40
Heads‐up: New roles for the fragile X mental retardation protein in neural stem and progenitor cells
Callan, M. A., & Zarnescu, D. C. (2011) · genesis · doi:10.1002/dvg.20745 · Cited by 39
Hirano, M., Yoshii, K., Sakai, M., Hasebe, R., Ichii, O., & Kariwa, H. (2014) · Journal of General Virology · doi:10.1099/vir.0.061432-0 · Cited by 40
Visual motion processing deficits in infants with the fragile X premutation
Gallego, P., Burris, J. L., & Rivera, S. M. (2014) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-6-29 · Cited by 39
Schaefer, T. L., Davenport, M. H., Grainger, L. M., Robinson, C. K., Earnheart, A. T., Stegman, M., Lang, A. L., Ashworth, A. A., Molinaro, G., Huber, K. M., et al. (2017) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-017-9184-y · Cited by 38
A Drosophila model of Fragile X syndrome exhibits defects in phagocytosis by innate immune cells
O'Connor, R. M., Stone, E. F., Wayne, C. R., Marcinkevicius, E., Ulgherait, M., Delventhal, R., Pantalia, M., Hill, V. M., Zhou, C. G., McAllister, S. F., et al. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201607093 · Cited by 39
Neuronal RNP granules: from physiological to pathological assemblies
Graeve, F. D., & Besse, F. (2018) · Biological Chemistry · doi:10.1515/hsz-2018-0141 · Cited by 43
Dendritic spine abnormalities in mental retardation
Halbach, O. V. B. U. (2010) · Cell and Tissue Research · doi:10.1007/s00441-010-1070-9 · Cited by 43
Rapoport, S. I. (1999) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00095-7 · Cited by 39
EPHB receptor signaling in dendritic spine development
Irie, F. (2004) · Frontiers in bioscience · doi:10.2741/1325 · Cited by 40
Adaptive control of synaptic plasticity integrates micro- and macroscopic network function
Scott, D. N., & Frank, M. J. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01374-6 · Cited by 40
Wallingford, J., Scott, A. L., Rodrigues, K., & Doering, L. C. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00268 · Cited by 38
Event-related potential alterations in fragile X syndrome
Knoth, I. S., & Lippé, S. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00264 · Cited by 43
Galvez, R., Smith, R. L., & Greenough, W. T. (2005) · Developmental Brain Research · doi:10.1016/j.devbrainres.2005.03.010 · Cited by 38
Self-citationThe Fragile X Mental Retardation Protein in Circadian Rhythmicity and Memory Consolidation
Gatto, C. L., & Broadie, K. S. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8057-0 · Cited by 38
Implications of mRNA translation dysregulation for neurological disorders
Jishi, A., Qi, X., & Miranda, H. C. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.09.005 · Cited by 40
Fmr1 KO and Fenobam Treatment Differentially Impact Distinct Synapse Populations of Mouse Neocortex
Wang, G. X., Smith, S. J., & Mourrain, P. (2014) · Neuron · doi:10.1016/j.neuron.2014.11.016 · Cited by 36
Lithium: A Promising Treatment for Fragile X Syndrome
Liu, Z., & Smith, C. B. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn500077p · Cited by 39
Perturbation of dendritic protrusions in intellectual disability
Levenga, J., & Willemsen, R. (2012) · Progress in brain research · doi:10.1016/b978-0-444-54299-1.00008-x · Cited by 38
Silverman, J. L., & Ellegood, J. (2018) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000537 · Cited by 35
How autophagy can restore proteostasis defects in multiple diseases?
Joshi, V., Upadhyay, A., Prajapati, V. K., & Mishra, A. (2020) · Medicinal Research Reviews · doi:10.1002/med.21662 · Cited by 40
Transcriptional Dysregulation of Neocortical Circuit Assembly in ASD
Kwan, K. Y. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-418700-9.00006-x · Cited by 39
Fragile X syndrome, the Fragile X related proteins, and animal models
Hoogeveen, A. T., Willemsen, R., & Oostra, B. A. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10064 · Cited by 36
Self-citationNew insights of altered lipid profile in Fragile X Syndrome
Çaku, A., Seidah, N. G., Lortie, A., Gagné, N., Perron, P., Dubé, J., & Corbin, F. (2017) · PLOS ONE · doi:10.1371/journal.pone.0174301 · Cited by 36
Won, J., Jin, Y., Choi, J., Park, S., Lee, T. Y., Lee, S., Chang, K., & Hong, Y. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061314 · Cited by 41
Koh, J., Lim, J. S., Byun, H.-R., & Yoo, M.-H. (2014) · Molecular Brain · doi:10.1186/s13041-014-0064-z · Cited by 37
Distinct Defects in Spine Formation or Pruning in Two Gene Duplication Mouse Models of Autism
Wang, M., Li, H., Takumi, T., Qiu, Z., Xu, X., Yu, X., & Bian, W.-J. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0111-8 · Cited by 36
An Intellectual Disability-Related Missense Mutation in Rac1 Prevents LTP Induction
Tian, C., Kay, Y., Sadybekov, A., Rao, S., Katritch, V., & Herring, B. E. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00223 · Cited by 35
The Ubiquitin System: a Regulatory Hub for Intellectual Disability and Autism Spectrum Disorder
Kasherman, M. A., Premarathne, S., Burne, T. H. J., Wood, S. A., & Piper, M. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01881-x · Cited by 41
Gocel, J., & Larson, J. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.06.052 · Cited by 39
A Comparative Perspective on Wnt/β-Catenin Signalling in Cell Fate Determination
Garcin, C. L., & Habib, S. J. (2017) · Results and problems in cell differentiation · doi:10.1007/978-3-319-53150-2_15 · Cited by 40
Restifo, L. L. (2005) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20083 · Cited by 35
Huang, Y., Méndez, R., Fernández, M., & Richter, J. D. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02088-x · Cited by 36
New innovations: Therapeutic opportunities for intellectual disabilities
Picker, J. D., & Walsh, C. A. (2013) · Annals of Neurology · doi:10.1002/ana.24002 · Cited by 38
Rami, G., Caillard, O., Medina, I., Pellegrino, C., Fattoum, A., Ben‐Ari, Y., & Ferhat, L. (2005) · Hippocampus · doi:10.1002/hipo.20145 · Cited by 36
Neurobiological Mechanisms of Autism Spectrum Disorder and Epilepsy, Insights from Animal Models
Sierra-Arregui, T., Llorente, J., Mínguez, P., Tønnesen, J., & Peñagarikano, O. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.02.043 · Cited by 34
Aitken, K. J. (2008) · The Keio Journal of Medicine · doi:10.2302/kjm.57.15 · Cited by 33
FMRP regulates actin filament organization via the armadillo protein p0071
Nolze, A., Schneider, J., Keil, R., Lederer, M., Hüttelmaier, S., Kessels, M. M., Qualmann, B., & Hatzfeld, M. (2013) · RNA · doi:10.1261/rna.037945.112 · Cited by 35
Limbic Epileptogenesis in a Mouse Model of Fragile X Syndrome
Qiu, L.-F., Lu, T., Hu, X.-L., Yi, Y., Liao, W., & Xiong, Z. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn163 · Cited by 33
Fragile X Syndrome: A Model of Gene-Brain-Behavior Relationships
Hagerman, R. J., & Hagerman, P. J. (2001) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2001.3225 · Cited by 33
Ornoy, A., Echefu, B. E., & Becker, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910469 · Cited by 36
Argonaute2 Suppresses Drosophila Fragile X Expression Preventing Neurogenesis and Oogenesis Defects
Pepper, A. S.-R., Beerman, R. W., Bhogal, B., & Jongens, T. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007618 · Cited by 32
Modeling of Autism Genetic Variations in Mice: Focusing on Synaptic and Microcircuit Dysfunctions
Qiu, S., Aldinger, K. A., & Levitt, P. R. (2012) · Developmental Neuroscience · doi:10.1159/000336644 · Cited by 33
Chen, C., Bajnath, A., & Brumberg, J. C. (2014) · Cerebral Cortex · doi:10.1093/cercor/bht415 · Cited by 32
Pathogenesis of Börjeson-Forssman-Lehmann syndrome: Insights from PHF6 function
Jahani‐Asl, A., Cheng, C., Zhang, C., & Bonni, A. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.09.011 · Cited by 37
Fragile X mental retardation syndrome: from pathogenesis to diagnostic issues
Mandel, J., & Biancalana, V. (2004) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2004.03.034 · Cited by 33
Molecular Regulation of Dendritic Spine Shape and Function
Sala, C. (2002) · Neurosignals · doi:10.1159/000065433 · Cited by 32
Zalfa, F., & Bagni, C. (2004) · Current Issues in Molecular Biology · doi:10.21775/cimb.006.073 · Cited by 33
FMRP Regulates Neurogenesis In Vivo in Xenopus laevis Tadpoles
Faulkner, R. L., Wishard, T. J., Thompson, C. K., Liu, H.-H., & Cline, H. T. (2014) · eNeuro · doi:10.1523/eneuro.0055-14.2014 · Cited by 33
Fragile X syndrome and the amygdala
Suvrathan, A., & Chattarji, S. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.04.005 · Cited by 31
Brick, D. J., Nethercott, H. E., Montesano, S., Bañuelos, M. G., Stover, A. E., Schutte, S. S., O’Dowd, D. K., Hagerman, R. J., Ono, M. Y., Hessl, D. R., et al. (2014) · Stem Cells Translational Medicine · doi:10.5966/sctm.2014-0073 · Cited by 31
Pharmacotherapy for Fragile X Syndrome: Progress to Date
Davenport, M. H., Schaefer, T. L., Friedmann, K., Fitzpatrick, S. E., & Erickson, C. A. (2016) · Drugs · doi:10.1007/s40265-016-0542-y · Cited by 33
nArgBP2 regulates excitatory synapse formation by controlling dendritic spine morphology
Lee, S., Kim, Y., Han, J.-K., Park, H.-Y., Lee, U., Na, M., Jeong, S., Chung, C., Cestra, G., & Chang, S. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1600944113 · Cited by 32
Li, B., Sumera, A., Booker, S. A., & McCullagh, E. A. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00062 · Cited by 32
Molecular and Genetic Analysis of the Drosophila Model of Fragile X Syndrome
Tessier, C. R., & Broadie, K. S. (2011) · Results and problems in cell differentiation · doi:10.1007/978-3-642-21649-7_7 · Cited by 31
Fragile X mental retardation 1 and Filamin A interact genetically in Drosophila long-term memory
Bolduc, F. V. (2010) · Frontiers in Neural Circuits · doi:10.3389/neuro.04.022.2009 · Cited by 32
A Golgi study of neuronal architecture in a genetic mouse model for Lesch–Nyhan disease
Mikolaenko, I., Rao, L. M., Roberts, R. C., Kolb, B. E., & Jinnah, H. A. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.04.005 · Cited by 31
Fragile X syndrome: from gene discovery to therapy
Heulens, I. (2010) · Frontiers in bioscience · doi:10.2741/3785 · Cited by 32
Gruß, M., & Braun, K. A. (2001) · Neural Plasticity · doi:10.1155/np.2001.285 · Cited by 31
Zhang, K., Li, Y.-J., Feng, D., Zhang, P., Wang, Y., Li, X., Liu, S., Wu, Y., & Zhao, M. (2017) · Scientific Reports · doi:10.1038/srep43594 · Cited by 32
Yau, S., Bettio, L. E. B., Vetrici, M. A., Truesdell, A., Chiu, C., Chiu, J., Truesdell, E., & Christie, B. R. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.01.014 · Cited by 30
Novel Features of dFMR1, the Drosophila Orthologue of the Fragile X Mental Retardation Protein
Schenck, A., Bor, V. V. D., Bardoni, B., & Giangrande, A. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0510 · Cited by 31
Selective serotonin reuptake inhibitors in intellectual disability
Racusin, R. J., Kovner-Kline, K., & King, B. H. (1999) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/(sici)1098-2779(1999)5:4 · Cited by 13
Boda, B., Mendez, P., Boury‐Jamot, B., Magara, F., & Muller, D. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12488 · Cited by 30
Rare genetic brain disorders with overlapping neurological and psychiatric phenotypes
Peall, K. J., Owen, M. J., & Hall, J. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00896-x · Cited by 33
Khlghatyan, J., Evstratova, A., Chamberland, S., Marakhovskaia, A., Bahremand, A., Tóth, K., & Beaulieu, J. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00119 · Cited by 31
Sears, J. C., Choi, W. J., & Broadie, K. S. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.02.004 · Cited by 30
Stress-Sensitive Protein Rac1 and Its Involvement in Neurodevelopmental Disorders
Wang, X., Liu, D., Wei, F., Li, Y., Wang, X., Li, L., Wang, G., Zhang, S., & Zhang, L. (2020) · Neural Plasticity · doi:10.1155/2020/8894372 · Cited by 33
Epigenetic regulation of neuronal dendrite and dendritic spine development
Smrt, R. D., & Zhao, X. (2010) · Frontiers in Biology · doi:10.1007/s11515-010-0650-0 · Cited by 35
Distribution of fragile X mental retardation protein in the human auditory brainstem
Beebe, K., Wang, Y., & Kulesza, R. J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.05.006 · Cited by 30
Localization of mRNAs at Synaptic Sites on Dendrites
Steward, O., & Worley, P. F. (2001) · Results and problems in cell differentiation · doi:10.1007/978-3-540-40025-7_1 · Cited by 30
Lauterborn, J. C., Jafari, M., Babayan, A. H., & Gall, C. M. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht249 · Cited by 31
Kulinich, A. O., Reinhard, S. M., Rais, M., Lovelace, J. W., Scott, V., Binder, D. K., Razak, K. A., & Ethell, I. M. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104622 · Cited by 30
Modelling fragile X syndrome in the laboratory setting: A behavioral perspective
Melancia, F., & Trezza, V. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.04.042 · Cited by 31
Experiential contributions to social dominance in a rat model of fragile-X syndrome
Saxena, K., Webster, J., Hallas-Potts, A., Mackenzie, R., Spooner, P. A., Thomson, D., Kind, P. C., Chatterji, S., & Morris, R. (2018) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2018.0294 · Cited by 27
Cardiovascular malformations and other cardiovascular abnormalities in neurofibromatosis 1
Lin, A. E., Birch, P. H., Korf, B. R., Tenconi, R., Niimura, M., Pöyhönen, M., Uhas, K. A., Sigorini, M., Virdis, R., Romano, C., et al. (2000) · American Journal of Medical Genetics · doi:10.1002/1096-8628(20001113)95:2 · Cited by 243
Ultrastructural analysis of the functional domains in FMRP using primary hippocampal mouse neurons
Levenga, J., Buijsen, R. A. M., Rife, M. F., Moine, H., Nelson, D. L., Oostra, B. A., Willemsen, R., & de Vrij, F. M. S. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.05.004 · Cited by 29
Self-citationRNA Targets of the Fragile X Protein
Kaytor, M. D., & Orr, H. T. (2001) · Cell · doi:10.1016/s0092-8674(01)00590-6 · Cited by 29
D’Incal, C., Broos, J., Torfs, T., Kooy, R. F., & Vanden Berghe, W. (2022) · Cells · doi:10.3390/cells11081325 · Cited by 29
Astrocytes regulate neuronal network activity by mediating synapse remodeling
Kim, N., & Chung, W. (2022) · Neuroscience Research · doi:10.1016/j.neures.2022.09.007 · Cited by 31
The RNA binding protein fragile X mental retardation protein promotes myelin sheath growth
Doll, C. A., Yergert, K. M., & Appel, B. (2019) · Glia · doi:10.1002/glia.23731 · Cited by 27
Ambrozkiewicz, M. C., Borisova, E. V., Schwark, M., Ripamonti, S., Schaub, T., Тихоновна, С. А., Weber, A. I., Rhee, H. J., Altas, B., Yilmaz, R., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0714-8 · Cited by 29
RNA-Binding Specificity of the Human Fragile X Mental Retardation Protein
Athar, Y. M., & Joseph, S. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.04.021 · Cited by 30
Homeostatic Roles of the Proteostasis Network in Dendrites
Lottes, E. N., & Cox, D. N. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00264 · Cited by 26
Impact of maternal immune activation on dendritic spine development
Pękała, M., Doliwa, M., & Kalita, K. B. (2020) · Developmental Neurobiology · doi:10.1002/dneu.22804 · Cited by 27
Ciranna, L., & Costa, L. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00524 · Cited by 30
Metadata
- Authors
- Comery, T. A., Harris, J. B., Willems, P. J., Oostra, B. A., Irwin, S. A., Weiler, I. J., & Greenough, W. T.
- Affiliations
- University of Antwerp (BE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1997-05-13
- Volume
- 94
- Issue
- 10
- Pages
- 5401-5404
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC24690
- OpenAlex
- W2022959185
- Cited by
- 1,046
- References
- 30
- Citations by year
- 2026: 15 · 2025: 14 · 2024: 28 · 2023: 20 · 2022: 35 · 2021: 24 · 2020: 34 · 2019: 38 · 2018: 35 · 2017: 52 · 2016: 41 · 2015: 45 · 2014: 64 · 2013: 57 · 2012: 43
- FWCI
- 14.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Funders
- FRAXA Research Foundation (MH35321)
- John D. and Catherine T. MacArthur Foundation
- National Institute of Mental Health (MH-35321, R01MH035321, R37MH035321)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- fragile X syndrome, FMRP, Fmr1 knockout mice, dendritic spines, dendritic spine morphology, synaptic pruning, synapse stabilization, layer 5 pyramidal neurons, occipital cortex, Golgi impregnation, postsynaptic spines
- MeSH terms
- Animals, Cerebral Cortex, Dendrites, Female, Fragile X Syndrome, Golgi Apparatus, Humans, Mice, Inbred Strains, Occipital Lobe, Pyramidal Cells, Mice, Knockout, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
