The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
AtMRP1 gene of Arabidopsis encodes a glutathione S -conjugate pump: Isolation and functional definition of a plant ATP-binding cassette transporter gene
Open accessAbstract
Because plants produce cytotoxic compounds to which they, themselves, are susceptible and are exposed to exogenous toxins (microbial products, allelochemicals, and agrochemicals), cell survival is contingent on mechanisms for detoxifying these agents. One detoxification mechanism is the glutathione S -transferase-catalyzed glutathionation of the toxin, or an activated derivative, and transport of the conjugate out of the cytosol. We show here that a transporter responsible for the removal of glutathione S -conjugates from the cytosol, a specific Mg 2+ -ATPase, is encoded by the AtMRP1 gene of Arabidopsis thaliana . The sequence of AtMRP1 and the transport capabilities of membranes prepared from yeast cells transformed with plasmid-borne AtMRP1 demonstrate that this gene encodes an ATP-binding cassette transporter competent in the transport of glutathione S -conjugates of xenobiotics and endogenous substances, including herbicides and anthocyanins.
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Cites
An Algorithm for Least-Squares Estimation of Nonlinear Parameters
Marquardt, D. W. (1963) · Journal of the Society for Industrial and Applied Mathematics · doi:10.1137/0111030 · Cited by 30,728
Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line
Cole, S. P. C., Bhardwaj, G., Gerlach, J. H., Mackie, J. E., Grant, C. E., Almquist, K. C., Stewart, A. J., Kurz, E. U., Duncan, A. M. V., & Deeley, R. G. (1992) · Science · doi:10.1126/science.1360704 · Cited by 3,037
Cited by
Molecular mechanisms of plant metal tolerance and homeostasis
Clemens, S. (2001) · Planta · doi:10.1007/s004250000458 · Cited by 1,417
Biochemical and physiological mechanisms mediated by allelochemicals
Weir, T. L., Park, S.-W., & Vivanco, J. M. (2004) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2004.05.007 · Cited by 773
AtPCS1, a phytochelatin synthase from Arabidopsis : Isolation and in vitro reconstitution
Vatamaniuk, O. K., Mari, S., Lu, Y.-P., & Rea, P. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.7110 · Cited by 410
Self-citationMechanism of Heavy Metal Ion Activation of Phytochelatin (PC) Synthase
Vatamaniuk, O. K., Mari, S., Lu, Y.-P., & Rea, P. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002997200 · Cited by 390
Self-citationToxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters
Leslie, E. (2001) · Toxicology · doi:10.1016/s0300-483x(01)00454-1 · Cited by 376
Metadata
- Authors
- Lu, Y.-P., Li, Z.-S., & Rea, P. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-07-22
- Volume
- 94
- Issue
- 15
- Pages
- 8243-8248
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2082545023
- Cited by
- 282
- References
- 2
- FWCI
- 6.16
- Type
- journal article
- Language
- en
- Open access
- green
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- Lu, Y.-P., Li, Z.-S., & Rea, P. A. (1997). AtMRP1 gene of Arabidopsis encodes a glutathione S -conjugate pump: Isolation and functional definition of a plant ATP-binding cassette transporter gene. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.15.8243
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