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Cited by 553

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

Open access
Song, Ho Yeong, Régnier, Catherine H., Kirschning, Carsten J., Goeddel, David V., Rothe, Mike·1997·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.94.18.9792
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Abstract

TNF-induced activation of the transcription factor NF-κB and the c-jun N-terminal kinase (JNK/SAPK) requires TNF receptor-associated factor 2 (TRAF2). The NF-κB-inducing kinase (NIK) associates with TRAF2 and mediates TNF activation of NF-κB. Herein we show that NIK interacts with additional members of the TRAF family and that this interaction requires the conserved “WKI” motif within the TRAF domain. We also investigated the role of NIK in JNK activation by TNF. Whereas overexpression of NIK potently induced NF-κB activation, it failed to stimulate JNK activation. A kinase-inactive mutant of NIK was a dominant negative inhibitor of NF-κB activation but did not suppress TNF- or TRAF2-induced JNK activation. Thus, TRAF2 is the bifurcation point of two kinase cascades leading to activation of NF-κB and JNK, respectively.

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Metadata

Authors
Song, H. Y., Régnier, C. H., Kirschning, C. J., Goeddel, D. V., & Rothe, M.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1997-09-02
Volume
94
Issue
18
Pages
9792-9796
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.94.18.9792
OpenAlex
W1986663284
Cited by
553
References
4
FWCI
27.54
Type
journal article
Language
en
Open access
green

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