The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Cockayne syndrome group B protein enhances elongation by RNA polymerase II
Open accessAbstract
Cockayne syndrome (CS) is characterized by impaired physical and mental development. Two complementation groups, CSA and CSB, have been identified. Here we report that the CSB gene product enhances elongation by RNA polymerase II. CSB stimulated the rate of elongation on an undamaged template by a factor of about 3. A thymine-thymine cyclobutane dimer located in the template strand is known to be a strong block to transcription. Addition of CSB to the blocked polymerase resulted in addition of one nucleotide to the nascent transcript. Finally, addition of transcription factor IIS is known to cause polymerase blocked at a thymine-thymine cyclobutane dimer to digest its nascent transcript, and CSB counteracted this transcript shortening action of transcription factor IIS. Thus a deficiency in transcription elongation may contribute to the CS phenotype.
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Sancar, A. (1996) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.65.070196.000355 · Cited by 1,131
Self-citationHenning, K. A., Li, L., Iyer, N., McDaniel, L. D., Reagan, M. S., Legerski, R., Schultz, R. A., Stefanini, M., Lehmann, A. R., Mayne, L. V., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90028-4 · Cited by 507
Selby, C. P., & Sancar, A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.3.1885 · Cited by 267
Self-citationRAD26, the functional S. cerevisiae homolog of the Cockayne syndrome B gene ERCC6.
van Gool, A. J., Verhage, R., Swagemakers, S. M., van de Putte, P., Brouwer, J., Troelstra, C., Bootsma, D., & Hoeijmakers, J. H. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06871.x · Cited by 246
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Metadata
- Authors
- Selby, C. P., & Sancar, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-10-14
- Volume
- 94
- Issue
- 21
- Pages
- 11205-11209
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2009536322
- Cited by
- 307
- References
- 5
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- green
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