The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation
Open accessAbstract
The structure of truncated human apolipoprotein A-I (apo A-I), the major protein component of high density lipoprotein, has been determined at 4-Å resolution. The crystals comprise residues 44–243 (exon 4) of apo A-I, a fragment that binds to lipid similarly to intact apo A-I and that retains the lipid-bound conformation even in the absence of lipid. The molecule consists almost entirely of a pseudo-continuous, amphipathic α-helix that is punctuated by kinks at regularly spaced proline residues; it adopts a shape similar to a horseshoe of dimensions 125 × 80 × 40 Å. Four molecules in the asymmetric unit associate via their hydrophobic faces to form an antiparallel four-helix bundle with an elliptical ring shape. Based on this structure, we propose a model for the structure of apo A-I bound to high density lipoprotein.
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Cites
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Apolipoprotein E structure: insights into function
Hatters, D. M., Peters-Libeu, C. A., & Weisgraber, K. H. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.06.008 · Cited by 583
Hagn, F., Etzkorn, M., Raschle, T., & Wagner, G. (2013) · Journal of the American Chemical Society · doi:10.1021/ja310901f · Cited by 498
The molecular biology and clinical features of amyloid neuropathy
Benson, M. D., & Kincaid, J. C. (2007) · Muscle & Nerve · doi:10.1002/mus.20821 · Cited by 447
Refined structures of mouse P‐glycoprotein
Li, J., Jaimes, K. F., & Aller, S. G. (2014) · Protein Science · doi:10.1002/pro.2387 · Cited by 344
The protofilament substructure of amyloid fibrils11Edited by F. E. Cohen
Serpell, L. C., Sunde, M., Benson, M. D., Tennent, G. A., Pepys, M. B., & Fraser, P. E. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3908 · Cited by 342
Metadata
- Authors
- Borhani, D. W., Rogers, D. P., Engler, J. A., & Brouillette, C. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-11-11
- Volume
- 94
- Issue
- 23
- Pages
- 12291-12296
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2123715983
- Cited by
- 434
- References
- 36
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- green
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- Borhani, D. W., Rogers, D. P., Engler, J. A., & Brouillette, C. G. (1997). Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.23.12291
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