The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
In vitro -generated neural precursors participate in mammalian brain development
Open accessAbstract
During embryogenesis, pluripotent stem cells segregate into daughter lineages of progressively restricted developmental potential. In vitro , this process has been mimicked by the controlled differentiation of embryonic stem cells into neural precursors. To explore the developmental potential of these cell-culture-derived precursors in vivo , we have implanted them into the ventricles of embryonic rats. The transplanted cells formed intraventricular neuroepithelial structures and migrated in large numbers into the brain tissue. Embryonic-stem-cell-derived neurons, astrocytes, and oligodendrocytes incorporated into telencephalic, diencephalic, and mesencephalic regions and assumed phenotypes indistinguishable from neighboring host cells. These observations indicate that entirely in vitro -generated neural precursors are able to respond to environmental signals guiding cell migration and differentiation and have the potential to reconstitute neuronal and glial lineages in the central nervous system.
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Cites
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
NeuN, a neuronal specific nuclear protein in vertebratesxs
Mullen, R. J., Buck, C. R., & Smith, A. M. (1992) · Development · doi:10.1242/dev.116.1.201 · Cited by 2,351
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Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 4,786
Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells
Lee, S.-H., Lumelsky, N., Studer, L., Auerbach, J. M., & McKay, R. D. (2000) · Nature Biotechnology · doi:10.1038/76536 · Cited by 1,257
Self-citationMultilineage differentiation from human embryonic stem cell lines
Odorico, J. S., Kaufman, D. S., & Thomson, J. A. (2001) · Stem Cells · doi:10.1634/stemcells.19-3-193 · Cited by 969
Metadata
- Authors
- Brüstle, O., Spiro, A. C., Karram, K., Choudhary, K., Okabe, S., & McKay, R. D. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-12-23
- Volume
- 94
- Issue
- 26
- Pages
- 14809-14814
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2147640763
- Cited by
- 311
- References
- 2
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Brüstle, O., Spiro, A. C., Karram, K., Choudhary, K., Okabe, S., & McKay, R. D. G. (1997). In vitro -generated neural precursors participate in mammalian brain development. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.26.14809
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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