The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to Eag and cyclic nucleotide-gated channels
Open accessAbstract
We have isolated a novel cDNA, that appears to represent a new class of ion channels, by using the yeast two-hybrid system and the SH3 domain of the neural form of Src (N-src) as a bait. The encoded polypeptide, BCNG-1, is distantly related to cyclic nucleotide-gated channels and the voltage-gated channels, Eag and H-erg. BCNG-1 is expressed exclusively in the brain, as a glycosylated protein of ≈132 kDa. Immunohistochemical analysis indicates that BCNG-1 is preferentially expressed in specific subsets of neurons in the neocortex, hippocampus, and cerebellum, in particular pyramidal neurons and basket cells. Within individual neurons, the BCNG-1 protein is localized to either the dendrites or the axon terminals depending on the cell type. Southern blot analysis shows that several other BCNG-related sequences are present in the mouse genome, indicating the emergence of an entire subfamily of ion channel coding genes. These findings suggest the existence of a new type of ion channel, which is potentially able to modulate membrane excitability in the brain and could respond to regulation by cyclic nucleotides.
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Cites
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Self-citationThe Role of the Funny Current in Pacemaker Activity
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Molecular identification of a hyperpolarization-activated channel in sea urchin sperm
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Metadata
- Authors
- Santoro, B., Grant, S. G. N., Bartsch, D., & Kandel, E. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-12-23
- Volume
- 94
- Issue
- 26
- Pages
- 14815-14820
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2004855428
- Cited by
- 274
- References
- 48
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Santoro, B., Grant, S. G. N., Bartsch, D., & Kandel, E. R. (1997). Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to Eag and cyclic nucleotide-gated channels. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.26.14815
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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