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Cited by 203

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells

Open access
Miyamoto, Hiroshi, Yeh, Shuyuan, Wilding, George, Chang, Chawnshang·1998·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.95.13.7379
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Abstract

Although hormone therapy with antiandrogens has been widely used for the treatment of prostate cancer, some antiandrogens may act as androgen receptor (AR) agonists that may result in antiandrogen withdrawal syndrome. The molecular mechanism of this agonist response, however, remains unclear. Using mammalian two-hybrid assay, we report that antiandrogens, hydroxyflutamide, bicalutamide (casodex), cyproterone acetate, and RU58841, and other compounds such as genistein and RU486, can promote the interaction between AR and its coactivator, ARA70, in a dose-dependent manner. The chloramphenicol acetyltransferase assay further demonstrates that these antiandrogens and related compounds significantly enhance the AR transcriptional activity by cotransfection of AR and ARA70 in a 1:3 ratio into human prostate cancer DU145 cells. Our results suggest that the agonist activity of antiandrogens might occur with the proper interaction of AR and ARA70 in DU145 cells. These findings may provide a good model to develop better antiandrogens without agonist activity.

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Metadata

Authors
Miyamoto, H., Yeh, S., Wilding, G., & Chang, C.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1998-06-23
Volume
95
Issue
13
Pages
7379-7384
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.95.13.7379
OpenAlex
W2129750923
Cited by
203
References
1
FWCI
18.85
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells. https://app.cochat.ai/papers/10.1073/pnas.95.13.7379
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Miyamoto, H., Yeh, S., Wilding, G., & Chang, C. (1998). Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.13.7379

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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