The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Cocaine reward models: Conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice
Open accessAbstract
Cocaine and methylphenidate block uptake by neuronal plasma membrane transporters for dopamine, serotonin, and norepinephrine. Cocaine also blocks voltage-gated sodium channels, a property not shared by methylphenidate. Several lines of evidence have suggested that cocaine blockade of the dopamine transporter (DAT), perhaps with additional contributions from serotonin transporter (5-HTT) recognition, was key to its rewarding actions. We now report that knockout mice without DAT and mice without 5-HTT establish cocaine-conditioned place preferences. Each strain displays cocaine-conditioned place preference in this major mouse model for assessing drug reward, while methylphenidate-conditioned place preference is also maintained in DAT knockout mice. These results have substantial implications for understanding cocaine actions and for strategies to produce anticocaine medications.
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Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
Pettit, H. O., Ettenberg, A., Bloom, F. E., & Koob, G. F. (1984) · Psychopharmacology · doi:10.1007/bf00427441 · Cited by 651
Cited by
Dopamine, learning and motivation.
Wise, R. A. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1406 · Cited by 3,379
Tzschentke, T. M. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00070.x · Cited by 1,336
Conditioned place preference: what does it add to our preclinical understanding of drug reward?
Bardo, M. T., & Bevins, R. A. (2000) · Psychopharmacology · doi:10.1007/s002130000569 · Cited by 1,241
Nucleus accumbens shell and core dopamine: differential role in behavior and addiction
Di Chiara, G. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00286-3 · Cited by 996
Plasma membrane monoamine transporters: structure, regulation and function
Torres, G. E., Gainetdinov, R. R., & Caron, M. G. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1008 · Cited by 939
Metadata
- Authors
- Sora, I., Wichems, C., Takahashi, N., Li, X.-F., Zeng, Z., Revay, R., Lesch, K.-P., Murphy, D. L., & Uhl, G. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-06-23
- Volume
- 95
- Issue
- 13
- Pages
- 7699-7704
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2134340301
- Cited by
- 505
- References
- 3
- FWCI
- 11.09
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Cocaine reward models: Conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice. https://app.cochat.ai/papers/10.1073/pnas.95.13.7699
- The paper
- Sora, I., Wichems, C., Takahashi, N., Li, X.-F., Zeng, Z., Revay, R., Lesch, K.-P., Murphy, D. L., & Uhl, G. R. (1998). Cocaine reward models: Conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.13.7699
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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