Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats

Pettit, Hugh O.; Ettenberg, Aaron; Bloom, Floyd E.; Koob, George F.

doi:10.1007/bf00427441

Cited by 651Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats

Pettit, Hugh O., Ettenberg, Aaron, Bloom, Floyd E., Koob, George F.·1984·Psychopharmacology

DOI 10.1007/bf00427441

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Abstract

The hypothesis that separate neural systems mediate the reinforcing properties of opioid and psychomotor stimulant drugs was tested by examining the role of mesolimbic dopamine (DA) neurons in maintaining intravenous heroin and cocaine self-administration. After local destruction of the DA terminals in the nucleus accumbens (NAcc) with 6-hydroxydopamine (6-OHDA), rats trained to self-administer cocaine and heroin on alternate days were observed for changes in their drug-seeking behaviors. Postlesion responding for cocaine showed a time-dependent decrease or extinction, whereas heroin self-administration showed a time-dependent recovery. By the fifth trial postlesion, heroin self-administration had recovered to 76% of prelesion baseline levels, but cocaine self-administration had dropped to 30% of prelesion baseline rates. Thus, selective lesions of the DA terminals in the nucleus accumbens significantly attenuate cocaine but not heroin self-administration. These data support the hypothesis that independent neural substrates are responsible for the reinforcing actions of these two drugs.

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Lesion or inactivation of the mesolimbic DA system in the VTA or NAc decreases cocaine, amphetamine, heroin, and nicotine self-administration in rats.
“In addition, lesion or inactivation of the mesolimbic DA system in the VTA [137,138] or in the NAc [139-143] decreases cocaine, amphetamine, heroin, and nicotine self-administration in rats.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [141]

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Authors: Pettit, H. O., Ettenberg, A., Bloom, F. E., & Koob, G. F.
Affiliations: Texas Christian University (US)
University of California, Santa Barbara (US)
Scripps Clinic (US)
ORCID: Koob, George F.
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 1984-10
Volume: 84
Issue: 2
Pages: 167-173
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/bf00427441
OpenAlex: W1964909230
Cited by: 651
References: 37
Citations by year: 2026: 5 · 2025: 7 · 2024: 7 · 2023: 9 · 2022: 15 · 2021: 6 · 2020: 13 · 2019: 16 · 2018: 10 · 2017: 9 · 2016: 11 · 2015: 13 · 2014: 15 · 2013: 15 · 2012: 17
FWCI: 5.74
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: nucleus accumbens, dopamine, cocaine self-administration, heroin self-administration, 6-hydroxydopamine lesion, drug reinforcement, opioid reinforcement, drug-seeking behavior
MeSH terms: Animals, Cocaine, Heroin, Dopamine, Hydroxydopamines, Male, Norepinephrine, Nucleus Accumbens, Rats, Inbred Strains, Self Administration, Septal Nuclei, 3,4-Dihydroxyphenylacetic Acid, Oxidopamine, Rats

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Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats

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