The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
The natural polyamine spermine functions directly as a free radical scavenger
Open accessAbstract
The polyamines are small organic cations that are absolutely required for eukaryotic cell growth. Although their growth requirements are well established, the molecular functions of the polyamines are ill-defined. Oxidative damage to DNA by reactive oxygen species is a continual problem that cells must guard against to survive. The polyamine spermine, which is normally found in millimolar concentrations in the nucleus, is shown here to function directly as a free radical scavenger, and adducts formed as a result of this function are identified. These data suggest that spermine is a major natural intracellular compound capable of protecting DNA from free radical attack.
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Cites
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Polyamines as Targets for Therapeutic Intervention
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Polyamines as Targets for Therapeutic Intervention
Marton, L. J. (1995) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.35.1.55 · Cited by 554
Interactions of polyamines with ion channels
WILLIAMS, K. (1997) · Biochemical Journal · doi:10.1042/bj3250289 · Cited by 498
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The role of polyamine catabolism in polyamine analogue-induced programmed cell death
Ha, H. C., Woster, P. M., Yager, J. D., & Casero, R. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11557 · Cited by 277
Self-citationZweier, J. L., Broderick, R., Kuppusamy, P., Thompson-Gorman, S., & Lutty, G. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)51062-6 · Cited by 244
Self-citationSite-specific Oxidative DNA Damage at Polyguanosines Produced by Copper Plus Hydrogen Peroxide
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Cited by
Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer?s disease
HYND, M. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2004.03.007 · Cited by 938
ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells
Snezhkina, A. V., Kudryavtseva, A. V., Kardymon, O. L., Savvateeva, M. V., Melnikova, N. V., Krasnov, G. S., & Dmitriev, A. A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/6175804 · Cited by 934
Polyamines: essential factors for growth and survival
Kusano, T., Berberich, T., Tateda, C., & Takahashi, Y. (2008) · Planta · doi:10.1007/s00425-008-0772-7 · Cited by 892
Role of reactive oxygen species in apoptosis: implications for cancer therapy
Matés, J. M., & Sánchez-Jiménez, F. M. (2000) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(99)00088-6 · Cited by 771
Remaining mysteries of molecular biology: the role of polyamines in the cell
Miller-Fleming, L., Olin-Sandoval, V., Campbell, K., & Ralser, M. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.06.020 · Cited by 658
Metadata
- Authors
- Ha, H. C., Sirisoma, N. S., Kuppusamy, P., Zweier, J. L., Woster, P. M., & Casero, R. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-09-15
- Volume
- 95
- Issue
- 19
- Pages
- 11140-11145
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1987176581
- Cited by
- 675
- References
- 26
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- green
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- Ha, H. C., Sirisoma, N. S., Kuppusamy, P., Zweier, J. L., Woster, P. M., & Casero, R. A. (1998). The natural polyamine spermine functions directly as a free radical scavenger. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.19.11140
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
