The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Activation of the genetically defined m1 muscarinic receptor potentiates N -methyl- d -aspartate (NMDA) receptor currents in hippocampal pyramidal cells
Open accessAbstract
Evidence suggests that cholinergic input to the hippocampus plays an important role in learning and memory and that degeneration of cholinergic terminals in the hippocampus may contribute to the memory loss associated with Alzheimer’s disease. One of the more prominent effects of cholinergic agonists on hippocampal physiology is the potentiation of N -methyl- d -aspartate (NMDA)-receptor currents by muscarinic agonists. Here, we employ traditional pharmacological reagents as well as m1-toxin, an m1 antagonist with unprecedented selectivity, to demonstrate that this potentiation of NMDA-receptor currents in hippocampal CA1 pyramidal cells is mediated by the genetically defined m1 muscarinic receptor. Furthermore, we demonstrate the colocalization of the m1 muscarinic receptor and the NR1a NMDA receptor subunit at the electron microscopic level, indicating a spatial relationship that would allow for physiological interactions between these two receptors. This work demonstrates that the m1-muscarinic receptor gene product modulates excitatory synaptic transmission, and it has important implications in the study of learning and memory as well as the design of drugs to treat neurodegenerative diseases such as Alzheimer’s.
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Cites
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Cited by
Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development
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Metabotropic Glutamate Receptors 1 and 5 Differentially Regulate CA1 Pyramidal Cell Function
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G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors
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Metadata
- Authors
- Marino, M. J., Rouse, S. T., Levey, A. I., Potter, L. T., & Conn, P. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-09-15
- Volume
- 95
- Issue
- 19
- Pages
- 11465-11470
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2050620515
- Cited by
- 275
- References
- 63
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Activation of the genetically defined m1 muscarinic receptor potentiates N -methyl- d -aspartate (NMDA) receptor currents in hippocampal pyramidal cells. https://app.cochat.ai/papers/10.1073/pnas.95.19.11465
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- Marino, M. J., Rouse, S. T., Levey, A. I., Potter, L. T., & Conn, P. J. (1998). Activation of the genetically defined m1 muscarinic receptor potentiates N -methyl- d -aspartate (NMDA) receptor currents in hippocampal pyramidal cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.19.11465
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
