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Muscarinic Receptor Subtypes
Open accessAbstract
In 1914, Sir Henry Dale provided the basis for the classical and comfortable definition of muscarinic and nicotinic acetylcholine receptors: Muscarinic receptors are selectively activated by muscarine and blocked by atropine; nicotinic receptors are activated by nicotine and blocked by curare. This definition lasted over 60 years, despite isolated reports that the picture might not be so simple. We now know, as the result of molecular biological studies, that there are multiple variants of both muscarinic and nicotinic receptors . These receptors are members of two quite separate gene superfamilies and only share the property of being activated by the same ligand, acetylcholine. The aim of this review is to discuss the structure, function, and binding properties of the different muscarinic receptor species, attempting where possible to coordinate the diverse experimental data into a uniform picture. For a more comprehensive review on muscarinic receptors, readers are di rected to a recent book by Brown (l).
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Raiteri, M., Leardi, R., & Marchi, M. (1984) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21528-2 · Cited by 314
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Bowes, J., Brown, A. J., Hamon, J., Jarolimek, W., Sridhar, A., Waldron, G., & Whitebread, S. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3845 · Cited by 748
Abrams, P., Andersson, K., Buccafusco, J. J., Chapple, C., de Groat, W. C., Fryer, A. D., Kay, G., Laties, A., Nathanson, N. M., Pasricha, P. J., et al. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706780 · Cited by 632
Modulatory functions of neurotransmitters in the striatum: ACh/dopamine/NMDA interactions
Di Chiara, G., Morelli, M., & Consolo, S. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90005-1 · Cited by 467
Muscarinic acetylcholine receptors: novel opportunities for drug development
Kruse, A. C., Kobilka, B. K., Gautam, D., Sexton, P. M., Christopoulos, A., & Wess, J. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4295 · Cited by 437
Metadata
- Authors
- Hulme, E. C., Birdsall, N. J. M., & Buckley, N. J.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 1990-04
- Volume
- 30
- Issue
- 1
- Pages
- 633-673
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2113630547
- Cited by
- 1,338
- References
- 1
- FWCI
- 36.87
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Muscarinic Receptor Subtypes. https://app.cochat.ai/papers/10.1146/annurev.pa.30.040190.003221
- The paper
- Hulme, E. C., Birdsall, N. J. M., & Buckley, N. J. (1990). Muscarinic Receptor Subtypes. Annual Review of Pharmacology and Toxicology. https://doi.org/10.1146/annurev.pa.30.040190.003221
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
