The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis
Open accessAbstract
Nonsteroidal antiinflammatory drugs (NSAIDs) can inhibit colorectal tumorigenesis and are among the few agents known to be useful for the chemoprevention of neoplasia. Here, we show that the tumor suppressive effects of NSAIDs are not likely to be related to a reduction in prostaglandins but rather are due to the elevation of the prostaglandin precursor arachidonic acid (AA). NSAID treatment of colon tumor cells results in a dramatic increase in AA that in turn stimulates the conversion of sphingomyelin to ceramide, a known mediator of apoptosis. These results have significant implications for understanding and improving colon cancer chemoprevention.
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Cited by
Surh, Y.-J., Chun, K.-S., Cha, H.-H., Han, S. S., Keum, Y.-S., Park, K.-K., & Lee, S. S. (2001) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(01)00183-x · Cited by 1,620
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Greenhough, A., Smartt, H. J. M., Moore, A. E., Roberts, H. R., Williams, A. C., Paraskeva, C., & Kaidi, A. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp014 · Cited by 1,220
PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs
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Self-citationThe molecular biology of cancer
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Metadata
- Authors
- Chan, T. A., Morin, P. J., Vogelstein, B., & Kinzler, K. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-01-20
- Volume
- 95
- Issue
- 2
- Pages
- 681-686
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2043944220
- Cited by
- 579
- References
- 39
- FWCI
- 39.14
- Type
- journal article
- Language
- en
- Open access
- green
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- Chan, T. A., Morin, P. J., Vogelstein, B., & Kinzler, K. W. (1998). Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.2.681
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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