The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Perturbation of the T cell repertoire in rheumatoid arthritis
Open accessAbstract
Aberrations in the T cell repertoire with the emergence of oligoclonal populations have been described in patients with rheumatoid arthritis (RA). However, the extent of the repertoire perturbations as well as the underlying mechanisms are not known. We now have examined the diversity of the peripheral CD4 T cell repertoire by determining the frequencies of arbitrarily selected T cell receptor (TCR) β-chain sequences. Healthy individuals displayed a highly diverse repertoire, with a median frequency of individual TCR β-chain sequences of 1 in 2.4 × 10 7 CD4 T cells. In RA patients, the median TCR β-chain frequency was increased 10-fold, indicating marked contraction of the repertoire (P< 0.001). The loss in TCR diversity was not limited to CD4 memory T cells but also involved the compartment of naive T cells, suggesting that it reflected an abnormality in T cell repertoire formation and not a consequence of antigen recognition in the synovium. Also, control patients with chronic inflammatory disease such as hepatitis C expressed a diverse repertoire indistinguishable from that of normals. Telomere length studies indicated an increased replicative history of peripheral CD4 T cells in RA patients, suggesting an enhanced turnover within the CD4 compartment. Compared with age-matched controls, terminal restriction fragment sizes were 1.7 kilobases shorter (P< 0.001). These data demonstrate an altered CD4 T cell homeostasis in RA that may contribute to the autoimmune response as well as to the immunodeficiency in these patients.
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T-cell antigen receptor genes and T-cell recognition
Davis, M. M., & Bjorkman, P. J. (1988) · Nature · doi:10.1038/334395a0 · Cited by 3,202
Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo
Tough, D. F., Borrow, P., & Sprent, J. (1996) · Science · doi:10.1126/science.272.5270.1947 · Cited by 1,077
β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells
Zijlstra, M., Bix, M., Simister, N. E., Loring, J. M., Raulet, D. H., & Jaenisch, R. (1990) · Nature · doi:10.1038/344742a0 · Cited by 1,012
Organ-Specific Disease Provoked by Systemic Autoimmunity
Kouskoff, V., Korganow, A.-S., Duchatelle, V., Degott, C., Benoist, C., & Mathis, D. (1996) · Cell · doi:10.1016/s0092-8674(00)81989-3 · Cited by 892
Mice lacking MHC class II molecules
Cosgrove, D., Gray, D., Dierich, A., Kaufman, J., Lemeur, M., Benoist, C., & Mathis, D. (1991) · Cell · doi:10.1016/0092-8674(91)90448-8 · Cited by 852
Pannetier, C., Cochet, M., Darche, S., Casrouge, A., Zöller, M., & Kourilsky, P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.4319 · Cited by 634
Positive selection of lymphocytes
von Boehmer, H. (1994) · Cell · doi:10.1016/0092-8674(94)90330-1 · Cited by 553
MHC Class-II Molecules and Autoimmunity
Nepom, G. T., & Erlich, H. (1991) · Annual Review of Immunology · doi:10.1146/annurev.iy.09.040191.002425 · Cited by 519
McInnes, I. B., Leung, B. P., Sturrock, R. D., Field, M., & Liew, F. Y. (1997) · Nature Medicine · doi:10.1038/nm0297-189 · Cited by 512
Schmidt, D., Goronzy, J. J., & Weyand, C. M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118638 · Cited by 482
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Cited by
T-Cell Function and Migration — Two Sides of the Same Coin
von Andrian, U. H., & Mackay, C. R. (2000) · New England Journal of Medicine · doi:10.1056/nejm200010053431407 · Cited by 1,437
Lee, D. M., & Weinblatt, M. E. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06075-5 · Cited by 1,247
A Direct Estimate of the Human αβ T Cell Receptor Diversity
Arstila, T. P., Casrouge, A., Baron, V., Even, J., Kanellopoulos, J., & Kourilsky, P. (1999) · Science · doi:10.1126/science.286.5441.958 · Cited by 931
The Influence of Age on T Cell Generation and TCR Diversity
Naylor, K., Li, G., Vallejo, A. N., Lee, W.-W., Koetz, K., Bryl, E., Witkowski, J., Fulbright, J., Weyand, C. M., & Goronzy, J. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.7446 · Cited by 802
Self-citationDiversity and clonal selection in the human T-cell repertoire
Qi, Q., Liu, Y., Cheng, Y., Glanville, J., Zhang, D., Lee, J.-Y., Olshen, R. A., Weyand, C. M., Boyd, S. D., & Goronzy, J. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409155111 · Cited by 755
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Metadata
- Authors
- Wagner, U. G., Koetz, K., Weyand, C. M., & Goronzy, J. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-11-24
- Volume
- 95
- Issue
- 24
- Pages
- 14447-14452
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1972298341
- Cited by
- 278
- References
- 37
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Wagner, U. G., Koetz, K., Weyand, C. M., & Goronzy, J. J. (1998). Perturbation of the T cell repertoire in rheumatoid arthritis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.24.14447
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