The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Widespread expression of beta‐defensin hBD‐1 in human secretory glands and epithelial cells
Abstract
We compared the expression of human α‐ and β‐defensins by various human tissues. mRNA for α‐defensins HNP1‐3, abundant in bone marrow, was detected in peripheral blood leukocytes, spleen and thymus by RT‐PCR, which revealed α‐defensins HD5 and HD6 only in the small intestine. In contrast, the pancreas and kidney expressed high levels of hBD‐1 and lower levels of this β‐defensin were found in many organs by RT‐PCR (salivary gland > trachea > prostate and placenta > thymus, testis, small intestine). hBD‐1 mRNA was produced constitutively by cultured normal human epithelial cells derived from the trachea, bronchi, small airways and the mammary gland. These largely non‐overlapping tissue distributions of human α‐ and β‐defensins suggest that hBD‐1 may be positioned to defend epithelial cells and mucosae from infection, whereas expression of HNP1‐3 in neutrophils and HD5 and HD6 in Paneth cells allows these α‐defensins to participate in systemic and small intestinal host defenses, respectively.
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Cites
Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein
Larrick, J. W., Hirata, M., Balint, R. F., Lee, J., Zhong, J., & Wright, S. C. (1995) · Infection and Immunity · doi:10.1128/iai.63.4.1291-1297.1995 · Cited by 573
hBD‐1: a novel β‐defensin from human plasma
Bensch, K. W., Raida, M., Mägert, H.-J., Schulz-Knappe, P., & Forssmann, W.-G. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00687-5 · Cited by 545
Paneth cells of the human small intestine express an antimicrobial peptide gene
Jones, D. E., & Bevins, C. L. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50079-x · Cited by 534
Selsted, M. E., Tang, Y. Q., Morris, W. L., McGuire, P. A., Novotny, M. J., Smith, W., Henschen, A. H., & Cullor, J. S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53298-1 · Cited by 443
Antibacterial peptides from pig intestine: isolation of a mammalian cecropin.
Lee, J. Y., Boman, A., Sun, C. X., Andersson, M., Jörnvall, H., Mutt, V, & Boman, H. G. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.23.9159 · Cited by 435
Epithelial Antibiotics Induced at Sites of Inflammation
Schonwetter, B. S., Stolzenberg, E. D., & Zasloff, M. A. (1995) · Science · doi:10.1126/science.7886453 · Cited by 407
Jones, D. E., & Bevins, C. L. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81160-2 · Cited by 341
Ganz, T., & Lehrer, R. I. (1994) · Current Opinion in Immunology · doi:10.1016/0952-7915(94)90145-7 · Cited by 337
Self-citationMallow, E. B., Harris, A., Salzman, N., Russell, J. P., DeBerardinis, R. J., Ruchelli, E., & Bevins, C. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.8.4038 · Cited by 296
Gallinacins: cysteine‐rich antimicrobial peptides of chicken leukocytes
Harwig, S. S. L., Swiderek, K. M., Kokryakov, V. N., Tan, L., Lee, T. D., Panyutich, E. A., Aleshina, G. M., Shamova, O. V., & Lehrer, R. I. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)80517-2 · Cited by 217
Self-citation
Cited by
Isolation and Characterization of Human μ-Defensin-3, a Novel Human Inducible Peptide Antibiotic
Harder, J., Bartels, J., Christophers, E., & Schröder, J.-M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008557200 · Cited by 1,311
Furrie, E., Macfarlane, S., Kennedy, A., Cummings, J. H., Walsh, S. V., O’Neil, D. A., & Macfarlane, G. T. (2005) · Gut · doi:10.1136/gut.2004.044834 · Cited by 766
Agerberth, B., Charo, J., Werr, J., Olsson, B., Idali, F., Lindbom, L., Kiessling, R., Jörnvall, H., Wigzell, H., & Gudmundsson, G. H. (2000) · Blood · doi:10.1182/blood.v96.9.3086 · Cited by 758
Yang, D., Biragyn, A., Hoover, D. M., Lubkowski, J., & Oppenheim, J. J. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104603 · Cited by 572
Liévin-Le Moal, V., & Servin, A. L. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.19.2.315-337.2006 · Cited by 568
Metadata
- Authors
- Zhao, C., Wang, I., & Lehrer, R. I.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1996-11-04
- Volume
- 396
- Issue
- 2-3
- Pages
- 319-322
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2060300255
- Cited by
- 561
- References
- 15
- FWCI
- 20.90
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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