The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex
Open accessAbstract
CBF1 is a member of the CSL family of DNA binding factors, which mediate either transcriptional repression or transcriptional activation. CSL proteins play a central role in Notch signaling and in Epstein–Barr virus-induced immortalization. Notch is a transmembrane protein involved in cell-fate decisions, and the cytoplasmic domain of Notch (NotchIC) targets CBF1. The Epstein–Barr virus-immortalizing protein EBNA2 activates both cellular and viral gene expression by targeting CBF1 and mimicking NotchIC. We have examined the mechanism of CBF1-mediated repression and show that CBF1 binds to a unique corepressor, CBF1 interacting corepressor (CIR). A CIR homolog is encoded by Caenorhabditis elegans, indicating that CIR is evolutionarily conserved. Two CBF1 mutants that were unable to bind CIR did not function as repressors, suggesting that targeting of CIR to CBF1 is an important component of repression. When expressed as a Gal4 fusion protein, CIR repressed reporter gene expression. CIR binds to histone deacetylase and to SAP30 and serves as a linker between CBF1 and the histone deacetylase complex.
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Cites
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Cited by
Notch signalling: a simple pathway becomes complex
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Ng (2000) · doi:10.1016/s0968-0004(00)01551-6 · Cited by 427
Crystal Structure of the CSL-Notch-Mastermind Ternary Complex Bound to DNA
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Metadata
- Authors
- Hsieh, J. J.-D., Zhou, S., Chen, L., Young, D. B., & Hayward, S. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-01-05
- Volume
- 96
- Issue
- 1
- Pages
- 23-28
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2082533656
- Cited by
- 305
- References
- 63
- FWCI
- 9.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hsieh, J. J.-D., Zhou, S., Chen, L., Young, D. B., & Hayward, S. D. (1999). CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.1.23
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