The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
β-Trcp couples β-catenin phosphorylation-degradation and regulates Xenopus axis formation
Open accessAbstract
Regulation of β-catenin stability is essential for Wnt signal transduction during development and tumorigenesis. It is well known that serine-phosphorylation of β-catenin by the Axin–glycogen synthase kinase (GSK)–3β complex targets β-catenin for ubiquitination–degradation, and mutations at critical phosphoserine residues stabilize β-catenin and cause human cancers. How β-catenin phosphorylation results in its degradation is undefined. Here we show that phosphorylated β-catenin is specifically recognized by β-Trcp, an F-box/WD40-repeat protein that also associates with Skp1, an essential component of the ubiquitination apparatus. β-catenin harboring mutations at the critical phosphoserine residues escapes recognition by β-Trcp, thus providing a molecular explanation for why these mutations cause β-catenin accumulation that leads to cancer. Inhibition of endogenous β-Trcp function by a dominant negative mutant stabilizes β-catenin, activates Wnt/β-catenin signaling, and induces axis formation in Xenopus embryos. Therefore, β-Trcp plays a central role in recruiting phosphorylated β-catenin for degradation and in dorsoventral patterning of the Xenopus embryo.
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Cited by
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Metadata
- Authors
- Liu, C., Kato, Y., Zhang, Z., Do, V. M., Yankner, B. A., & He, X.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-05-25
- Volume
- 96
- Issue
- 11
- Pages
- 6273-6278
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2142522741
- Cited by
- 398
- References
- 46
- FWCI
- 6.42
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: β-Trcp couples β-catenin phosphorylation-degradation and regulates Xenopus axis formation. https://app.cochat.ai/papers/10.1073/pnas.96.11.6273
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- Liu, C., Kato, Y., Zhang, Z., Do, V. M., Yankner, B. A., & He, X. (1999). β-Trcp couples β-catenin phosphorylation-degradation and regulates Xenopus axis formation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.11.6273
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