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The Arabidopsis thaliana HY1 locus, required for phytochrome-chromophore biosynthesis, encodes a protein related to heme oxygenases
Open accessAbstract
The hy1 mutants of Arabidopsis thaliana fail to make the phytochrome-chromophore phytochromobilin and therefore are deficient in a wide range of phytochrome-mediated responses. Because this defect can be rescued by feeding seedlings biliverdin IXα, it is likely that the mutations affect an enzyme that converts heme to this phytochromobilin intermediate. By a combination of positional cloning and candidate-gene isolation, we have identified the HY1 gene and found it to be related to cyanobacterial, algal, and animal heme oxygenases. Three independent alleles of hy1 contain DNA lesions within the HY1 coding region, and a genomic sequence spanning the HY1 locus complements the hy1–1 mutation. HY1 is a member of a gene family and is expressed in a variety of A. thaliana tissues. Based on its homology, we propose that HY1 encodes a higher-plant heme oxygenase, designated At HO1, responsible for catalyzing the reaction that opens the tetrapyrrole ring of heme to generate biliverdin IXα.
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Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741
Liscum, E., & Briggs, W. R. (1996) · Plant Physiology · doi:10.1104/pp.112.1.291 · Cited by 140
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Bacteriophytochromes are photochromic histidine kinases using a biliverdin chromophore
Bhoo, S.-H., Davis, S. J., Walker, J., Karniol, B., & Vierstra, R. D. (2001) · Nature · doi:10.1038/414776a · Cited by 320
Self-citationRPT2: A Signal Transducer of the Phototropic Response in Arabidopsis
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Metadata
- Authors
- Davis, S. J., Kurepa, J., & Vierstra, R. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-05-25
- Volume
- 96
- Issue
- 11
- Pages
- 6541-6546
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2082925435
- Cited by
- 235
- References
- 2
- FWCI
- 19.80
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The Arabidopsis thaliana HY1 locus, required for phytochrome-chromophore biosynthesis, encodes a protein related to heme oxygenases. https://app.cochat.ai/papers/10.1073/pnas.96.11.6541
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- Davis, S. J., Kurepa, J., & Vierstra, R. D. (1999). The Arabidopsis thaliana HY1 locus, required for phytochrome-chromophore biosynthesis, encodes a protein related to heme oxygenases. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.11.6541
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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