The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
CPF: An orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7α-hydroxylase gene
Open accessAbstract
Cholesterol 7α-hydroxylase is the first and rate-limiting enzyme in a pathway through which cholesterol is metabolized to bile acids. The gene encoding cholesterol 7α-hydroxylase, CYP7A , is expressed exclusively in the liver. Overexpression of CYP7A in hamsters results in a reduction of serum cholesterol levels, suggesting that the enzyme plays a central role in cholesterol homeostasis. Here, we report the identification of a hepatic-specific transcription factor that binds to the promoter of the human CYP7A gene. We designate this factor CPF, for CYP7A promoter binding factor. Mutation of the CPF binding site within the CYP7A promoter abolished hepatic-specific expression of the gene in transient transfection assays. A cDNA encoding CPF was cloned and identified as a human homolog of the Drosophila orphan nuclear receptor fushi tarazu F1 (Ftz-F1). Cotransfection of a CPF expression plasmid and a CYP7A reporter gene resulted in specific induction of CYP7A -directed transcription. These observations suggest that CPF is a key regulator of human CYP7A gene expression in the liver.
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The Enzymes, Regulation, and Genetics of Bile Acid Synthesis
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A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
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Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors
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Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23
Degirolamo, C., Sabbà, C., & Moschetta, A. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.9 · Cited by 424
Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism
Eloranta, J. J., & Kullak-Ublick, G. A. (2005) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.09.019 · Cited by 260
Metadata
- Authors
- Nitta, M., Ku, S., Brown, C., Okamoto, A. Y., & Shan, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-06-08
- Volume
- 96
- Issue
- 12
- Pages
- 6660-6665
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2064966728
- Cited by
- 283
- References
- 10
- FWCI
- 22.38
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: CPF: An orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7α-hydroxylase gene. https://app.cochat.ai/papers/10.1073/pnas.96.12.6660
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- Nitta, M., Ku, S., Brown, C., Okamoto, A. Y., & Shan, B. (1999). CPF: An orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7α-hydroxylase gene. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.12.6660
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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