Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors

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Bile acid biosynthesis

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An Orphan Nuclear Hormone Receptor That Lacks a DNA Binding Domain and Heterodimerizes with Other Receptors

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DAX-1 Inhibits SF-1-Mediated Transactivation via a Carboxy-Terminal Domain That Is Deleted in Adrenal Hypoplasia Congenita

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Nuclear Receptor DAX-1 Recruits Nuclear Receptor Corepressor N-CoR to Steroidogenic Factor 1

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The Orphan Nuclear Receptor SHP Inhibits Hepatocyte Nuclear Factor 4 and Retinoid X Receptor Transactivation: Two Mechanisms for Repression

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Identification of Nuclear Receptor mRNAs by RT-PCR Amplification of Conserved Zinc-Finger Motif Sequences

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The α1-Fetoprotein Locus Is Activated by a Nuclear Receptor of the Drosophila FTZ-F1 Family

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Disruption of Cholesterol 7α-Hydroxylase Gene in Mice

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Nuclear Orphan Receptors Control Cholesterol Catabolism

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Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols

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The Orphan Nuclear Receptor SHP Inhibits Agonist-dependent Transcriptional Activity of Estrogen Receptors ERα and ERβ

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α1-Fetoprotein Transcription Factor Is Required for the Expression of Sterol 12α-Hydroxylase, the Specific Enzyme for Cholic Acid Synthesis

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Steroidogenic Factor-1: Its Role in Endocrine Organ Development and Differentiation

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Activation of the Promoter of the Orphan Receptor SHP by Orphan Receptors That Bind DNA as Monomers

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Regulation of Bile Acid Biosynthesis

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Identification of a bile acid response element in the cholesterol 7 alpha-hydroxylase gene CYP7A

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Regulation of sterol 12α-hydroxylase and cholic acid biosynthesis in the rat

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Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

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Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

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A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

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Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

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Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

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Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

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Thematic review series: The Pathogenesis of Atherosclerosis. Effects of infection and inflammation on lipid and lipoprotein metabolism mechanisms and consequences to the host

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Targeting bile‐acid signalling for metabolic diseases

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Bile acids and the gut microbiota: metabolic interactions and impacts on disease

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Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

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Vitamin D Receptor As an Intestinal Bile Acid Sensor

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Bile salt transporters: molecular characterization, function, and regulation

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Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

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Resveratrol Attenuates Trimethylamine- <i>N</i> -Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota

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Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

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Bile acids as regulatory molecules

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Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis

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Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor

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The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis

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Molecular physiology of bile acid signaling in health, disease, and aging

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The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

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Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

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Bile Acids as Hormones: The FXR-FGF15/19 Pathway

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Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase–Dependent Regulation of the Orphan Nuclear Receptor SHP

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FXR: a metabolic regulator and cell protector

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Microbiota Modification with Probiotics Induces Hepatic Bile Acid Synthesis via Downregulation of the Fxr-Fgf15 Axis in Mice

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FXR, a multipurpose nuclear receptor

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FXR Acetylation Is Normally Dynamically Regulated by p300 and SIRT1 but Constitutively Elevated in Metabolic Disease States

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Circadian Clock Control of Liver Metabolic Functions

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Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis

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Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis

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The Mouse Microbiome Is Required for Sex-Specific Diurnal Rhythms of Gene Expression and Metabolism

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Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats

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Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism

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Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism

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New insights into bacterial bile resistance mechanisms: the role of bile salt hydrolase and its impact on human health

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Cholic acid mediates negative feedback regulation of bile acid synthesis in mice

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Metabolic Messengers: bile acids

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Intestinal absorption of bile acids in health and disease

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Molecular basis of bile acid-FXR-FGF15/19 signaling axis

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A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis

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Bile acids and their receptors

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The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis

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Identification of Farnesoid X Receptor β as a Novel Mammalian Nuclear Receptor Sensing Lanosterol

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Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration

Li, Y. T. Y., Swales, K. E., Thomas, G. J., Warner, T. D., & Bishop-Bailey, D. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.152694 · Cited by 171 · see citing works

Comprehensive Analysis of Serum and Fecal Bile Acid Profiles and Interaction with Gut Microbiota in Primary Biliary Cholangitis

Chen, W., Wei, Y., Xiong, A., Li, Y., Guan, H., Wang, Q., Miao, Q., Bian, Z., Xiao, X., Lian, M., et al. (2020) · Clinical Reviews in Allergy &amp; Immunology · doi:10.1007/s12016-019-08731-2 · Cited by 166 · see citing works

Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine in mice

Zhang, L., Wang, Y.-D., Chen, W.-D., Wang, X., Lou, G., Liu, N., Lin, M., Forman, B. M., & Huang, W. (2012) · Hepatology · doi:10.1002/hep.25905 · Cited by 151 · see citing works

Nuclear receptors as therapeutic targets in cholestatic liver diseases

Zollner, G., & Trauner, M. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00030.x · Cited by 146 · see citing works

Transcriptional regulation of hepatic stellate cells

Mann, J., & Mann, D. A. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.03.011 · Cited by 119 · see citing works

Cholesterol 7α-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders

Ferrell, J. M., Boehme, S., Li, F., & Chiang, J. Y. L. (2016) · Journal of Lipid Research · doi:10.1194/jlr.m064709 · Cited by 112 · see citing works

Farnesoid X Receptor Alleviates Age-Related Proliferation Defects in Regenerating Mouse Livers by Activating Forkhead Box M1b Transcription

Chen, W.-D., Wang, Y.-D., Zhang, L., Shiah, S., Wang, M., Yang, F., Yu, D., Forman, B. M., & Huang, W. (2010) · Hepatology · doi:10.1002/hep.23390 · Cited by 115 · see citing works

Reciprocal Regulation of a Glucocorticoid Receptor-Steroidogenic Factor-1 Transcription Complex on the Dax-1 Promoter by Glucocorticoids and Adrenocorticotropic Hormone in the Adrenal Cortex

Gummow, B. M., Scheys, J. O., Cancelli, V. R., & Hammer, G. D. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0461 · Cited by 114 · see citing works

Nuclear receptor-mediated repression of human cholesterol 7α-hydroxylase gene transcription by bile acids

Chen, W., Owsley, E., Yang, Y., Stroup, D., & Chiang, J. Y. L. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30272-8 · Cited by 112 · see citing works

Bile acids: From digestion to cancers

Baptissart, M., Vega, A., Maqdasy, S., Caira, F., Baron, S., Lobaccaro, J.-M. A., & Volle, D. H. (2013) · Biochimie · doi:10.1016/j.biochi.2012.06.022 · Cited by 97 · see citing works

Nuclear receptors as therapeutic targets in liver disease: are we there yet?

Rudraiah, S., Zhang, X., & Wang, L. (2016) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103209 · Cited by 87 · see citing works

Nonsteroidal FXR Ligands: Current Status and Clinical Applications

Gege, C., Hambruch, E., Hambruch, N., Kinzel, O., & Kremoser, C. (2019) · Handbook of Experimental Pharmacology · doi:10.1007/164_2019_232 · Cited by 83 · see citing works

Role of bile acids in the regulation of the metabolic pathways

Taoka, H., Yokoyama, Y., Morimoto, K., Kitamura, N., Tanigaki, T., Takashina, Y., Tsubota, K., & Watanabe, M. (2016) · World Journal of Diabetes · doi:10.4239/wjd.v7.i13.260 · Cited by 80 · see citing works

Quantification of bile acids: a mass spectrometry platform for studying gut microbe connection to metabolic diseases

Choucair, I., Nemet, I., Li, L., Cole, M. A., Skye, S. M., Kirsop, J. D., Fischbach, M. A., Gogonea, V., Brown, J. M., Tang, W. H. W., et al. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra119000311 · Cited by 77 · see citing works

Na + -taurocholate cotransporting polypeptide inhibition has hepatoprotective effects in cholestasis in mice

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Administration of Ampicillin Elevates Hepatic Primary Bile Acid Synthesis through Suppression of Ileal Fibroblast Growth Factor 15 Expression

Miyata, M., Takamatsu, Y., Kuribayashi, H., & Yamazoe, Y. (2009) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.160093 · Cited by 72 · see citing works

Loss of orphan receptor small heterodimer partner sensitizes mice to liver injury from obstructive cholestasis

Park, Y. J., Qatanani, M., Chua, S. S., LaRey, J. L., Johnson, S. A., Watanabe, M., Moore, D. D., & Lee, Y. K. (2008) · Hepatology · doi:10.1002/hep.22196 · Cited by 68 · see citing works

Mouse phenogenomics: the fast track to “systems metabolism

Argmann, C. A., Chambon, P., & Auwerx, J. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.11.002 · Cited by 51 · see citing works

Nuclear Receptors in Nonalcoholic Fatty Liver Disease

López-Velázquez, J. A., Carrillo-Córdova, L. D., Chávez-Tapia, N. C., Uribe, M., & Méndez-Sánchez, N. (2012) · Journal of Lipids · doi:10.1155/2012/139875 · Cited by 48 · see citing works

The coming of age of our understanding of the enterohepatic circulation of bile salts

Redinger, R. N. (2003) · The American Journal of Surgery · doi:10.1016/s0002-9610(02)01212-6 · Cited by 46 · see citing works

Farnesoid X receptor alpha: a molecular link between bile acids and steroid signaling

Baptissart, M., Vega, A., Martinot, E., Baron, S., Lobaccaro, J.-M. A., & Volle, D. H. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1387-0 · Cited by 32 · see citing works

Alteration in bile acids profile in large white pigs during chronic heat exposure

Fang, W., Wen, X., Meng, Q., Wu, W., Everaert, N., Xie, J., & Zhang, H. (2019) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2019.07.027 · Cited by 26 · see citing works

Activation of Constitutive Androstane Receptor (CAR) in mice results in maintained biliary excretion of bile acids despite a marked decrease of bile acids in liver

Lickteig, A. J., Csanaky, I. L., Pratt-Hyatt, M., & Klaassen, C. D. (2016) · Toxicological Sciences · doi:10.1093/toxsci/kfw054 · Cited by 26 · see citing works

Local synthesis of immunosuppressive glucocorticoids in the intestinal epithelium regulates anti-viral immune responses

Huang, J., Jia, R., & Brunner, T. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.08.009 · Cited by 24 · see citing works

Effects of absence of Constitutive Androstane Receptor (CAR) on bile acid homeostasis in male and female mice

Lickteig, A. J., Zhang, Y., Klaassen, C. D., & Csanaky, I. L. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz143 · Cited by 7 · see citing works

Liver Receptor Homolog-1 Regulates Bile Acid Homeostasis but Is Not Essential for Feedback Regulation of Bile Acid Synthesis

Lee, Y.-K., Schmidt, D. R., Cummins, C. L., Choi, M., Peng, L., Zhang, Y., Goodwin, B. J., Hammer, R. E., Mangelsdorf, D. J., & Kliewer, S. A. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0565 · Cited by 151 · see citing works

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00051-4 · Cited by 1,940 · see citing works

Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis

Sanyal, S., Båvner, A., Haroniti, A., Nilsson, L.-M., Lundåsen, T., Rehnmark, S., Witt, M. R., Einarsson, C., Talianidis, I., Gustafsson, J.-Α., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706736104 · Cited by 95 · see citing works

Loss of Nuclear Receptor SHP Impairs but Does Not Eliminate Negative Feedback Regulation of Bile Acid Synthesis

Kerr, T. A., Saeki, S., Schneider, M., Schaefer, K., Berdy, S., Redder, T., Shan, B., Russell, D. W., & Schwarz, M. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00154-5 · Cited by 351 · see citing works

Differential Regulation of Rat and HumanCYP7A1by the Nuclear Oxysterol Receptor Liver X Receptor-α

Goodwin, B. J., Watson, M. A., Kim, H., Miao, J., Kemper, J. K., & Kliewer, S. A. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0246 · Cited by 196 · see citing works