The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
“Global” cell replacement is feasible via neural stem cell transplantation: Evidence from the dysmyelinated shiverer mouse brain
Open accessAbstract
Many diseases of the central nervous system (CNS), particularly those of genetic, metabolic, or infectious/inflammatory etiology, are characterized by “global” neural degeneration or dysfunction. Therapy might require widespread neural cell replacement, a challenge not regarded conventionally as amenable to neural transplantation. Mouse mutants characterized by CNS-wide white matter disease provide ideal models for testing the hypothesis that neural stem cell transplantation might compensate for defective neural cell types in neuropathologies requiring cell replacement throughout the brain. The oligodendrocytes of the dysmyelinated shiverer ( shi ) mouse are “globally” dysfunctional because they lack myelin basic protein (MBP) essential for effective myelination. Therapy, therefore, requires widespread replacement with MBP-expressing oligodendrocytes. Clonal neural stem cells transplanted at birth—using a simple intracerebroventricular implantation technique—resulted in widespread engraftment throughout the shi brain with repletion of MBP. Accordingly, of the many donor cells that differentiated into oligodendroglia—there appeared to be a shift in the fate of these multipotent cells toward an oligodendroglial fate—a subgroup myelinated up to 52% (mean = ≈40%) of host neuronal processes with better compacted myelin of a thickness and periodicity more closely approximating normal. A number of recipient animals evinced decrement in their symptomatic tremor. Therefore, “global” neural cell replacement seems feasible for some CNS pathologies if cells with stem-like features are used.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(1991) · Medical Entomology and Zoology · Cited by 1,512
Stem Cells in the Central Nervous System
McKay, R. (1997) · Science · doi:10.1126/science.276.5309.66 · Cited by 1,472
Regulatory Mechanisms in Stem Cell Biology
Morrison, S. J., Shah, N. M., & Anderson, D. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81867-x · Cited by 1,043
Gritti, A., Parati, E., Cova, L., Frolichsthal, P., Galli, R., Wanke, E., Faravelli, L., Morassutti, D., Roisen, F., Nickel, D., et al. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-03-01091.1996 · Cited by 1,030
Multipotent neural cell lines can engraft and participate in development of mouse cerebellum
Snyder, E. Y., Deitcher, D. L., Walsh, C., Arnold-Aldea, S., Hartwieg, E. A., & Cepko, C. L. (1992) · Cell · doi:10.1016/0092-8674(92)90204-p · Cited by 915
Self-citationIsolation, Characterization, and use of Stem Cells from the CNS
Gage, F. H., Ray, J., & Fisher, L. J. (1995) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.18.030195.001111 · Cited by 829
Flax, J. D., Aurora, S., Yang, C., Simonin, C., Wills, A. M., Billinghurst, L. L., Jendoubi, M., Sidman, R. L., Wolfe, J. H., Kim, S. U., et al. (1998) · Nature Biotechnology · doi:10.1038/3473 · Cited by 770
Self-citationVescovi, A. L., Parati, E. A., Gritti, A., Poulin, P., Ferrario, M., Wanke, E., Frölichsthal-Schoeller, P., Cova, L., Arcellana-Panlilio, M., Colombo, A., et al. (1999) · Experimental Neurology · doi:10.1006/exnr.1998.6998 · Cited by 558
Is there a neural stem cell in the mammalian forebrain?
Weiss, S., Reynolds, B. A., Vescovi, A. L., Morshead, C., Craig, C. G., & der Kooy, D. V. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10035-7 · Cited by 528
Neural progenitor cell engraftment corrects lysosomal storage throughout the MRS VII mouse brain
Snyder, E. Y., Taylor, R. M., & Wolfe, J. H. (1995) · Nature · doi:10.1038/374367a0 · Cited by 473
Self-citation
Cited by
Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 4,786
Biology of Oligodendrocyte and Myelin in the Mammalian Central Nervous System
Baumann, N., & Pham-Dinh, D. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.871 · Cited by 1,828
Aboody, K. S., Brown, A., Rainov, N. G., Bower, K. A., Liu, S., Yang, W., Small, J. E., Herrlinger, U., Ourednik, V., Black, P. M., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.23.12846 · Cited by 1,207
Self-citationNistor, G. I., Totoiu, M. O., Haque, N., Carpenter, M. K., & Keirstead, H. S. (2005) · Glia · doi:10.1002/glia.20127 · Cited by 580
Windrem, M. S., Nunes, M. C., Rashbaum, W. K., Schwartz, T. H., Goodman, R. A., McKhann, G., Roy, N. S., & Goldman, S. A. (2004) · Nature Medicine · doi:10.1038/nm974 · Cited by 451
Metadata
- Authors
- Yandava, B. D., Billinghurst, L. L., & Snyder, E. Y.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-06-08
- Volume
- 96
- Issue
- 12
- Pages
- 7029-7034
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2094505884
- Cited by
- 396
- References
- 33
- FWCI
- 7.64
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: “Global” cell replacement is feasible via neural stem cell transplantation: Evidence from the dysmyelinated shiverer mouse brain. https://app.cochat.ai/papers/10.1073/pnas.96.12.7029
- The paper
- Yandava, B. D., Billinghurst, L. L., & Snyder, E. Y. (1999). “Global” cell replacement is feasible via neural stem cell transplantation: Evidence from the dysmyelinated shiverer mouse brain. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.12.7029
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
