The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation
Abstract
Human embryonic stem cells (hESCs) demonstrate remarkable proliferative and developmental capacity. Clinical interest arises from their ability to provide an apparently unlimited cell supply for transplantation, and from the hope that they can be directed to desirable phenotypes in high purity. Here we present for the first time a method for obtaining oligodendrocytes and their progenitors in high yield from hESCs. We expanded hESCs, promoted their differentiation into oligodendroglial progenitors, amplified those progenitors, and then promoted oligodendroglial differentiation using positive selection and mechanical enrichment. Transplantation into the shiverer model of dysmyelination resulted in integration, differentiation into oligodendrocytes, and compact myelin formation, demonstrating that these cells display a functional phenotype. This differentiation protocol provides a means of generating human oligodendroglial lineage cells in high purity, for use in studies of lineage development, screening assays of oligodendroglial‐specific compounds, and treating neurodegenerative diseases and traumatic injuries to the adult CNS. © 2004 Wiley‐Liss, Inc.
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Cited by
Remyelination in the CNS: from biology to therapy
Franklin, R. J. M., & ffrench-Constant, C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2480 · Cited by 1,544
Douvaras, P., Wang, J., Zimmer, M., Hanchuk, S., O’Bara, M. A., Sadiq, S., Sim, F. J., Goldman, J., & Fossati, V. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.06.012 · Cited by 302
Differentiation of spinal motor neurons from pluripotent human stem cells
Hu, B.-Y., & Zhang, S.-C. (2009) · Nature Protocols · doi:10.1038/nprot.2009.127 · Cited by 298
Neural Subtype Specification from Human Pluripotent Stem Cells
Tao, Y., & Zhang, S.-C. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.10.015 · Cited by 287
Führmann, T., Tam, R. Y., Ballarin, B., Coles, B., Elliott Donaghue, I., van der Kooy, D., Nagy, A., Tator, C. H., Morshead, C. M., & Shoichet, M. S. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2015.12.032 · Cited by 192
Metadata
- Authors
- Nistor, G. I., Totoiu, M. O., Haque, N., Carpenter, M. K., & Keirstead, H. S.
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2004-11-10
- Volume
- 49
- Issue
- 3
- Pages
- 385-396
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- OpenAlex
- W2168579634
- Cited by
- 580
- References
- 59
- FWCI
- 10.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nistor, G. I., Totoiu, M. O., Haque, N., Carpenter, M. K., & Keirstead, H. S. (2005). Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation. Glia. https://doi.org/10.1002/glia.20127
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