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Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3
Open accessAbstract
Two types of photoreceptors, rods and cones, coexist in the vertebrate retina. An in-depth analysis of the retinal circuitry that transmits rod and cone signals has been hampered by the presence of intimate physical and functional connections between rod and cone pathways. By deleting the cyclic nucleotide-gated channel CNG3 we have generated a mouse lacking any cone-mediated photoresponse. In contrast, the rod pathway is completely intact in CNG3-deficient mice. The functional loss of cone function correlates with a progressive degeneration of cone photoreceptors but not of other retinal cell types. CNG3-deficient mice provide an animal model to dissect unequivocally the contribution of rod and cone pathways for normal retinal function.
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Cited by
Hattar, S., Lucas, R. J., Mrosovsky, N., Thompson, S., Douglas, R. H., Hankins, M. W., Lem, J., Biel, M., Hofmann, F., Foster, R. G., et al. (2003) · Nature · doi:10.1038/nature01761 · Cited by 1,245
Self-citationMünzel, T., Feil, R., Mülsch, A., Lohmann, S. M., Hofmann, F., & Walter, U. (2003) · Circulation · doi:10.1161/01.cir.0000094403.78467.c3 · Cited by 316
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Kaupp, U. B., Kashikar, N. D., & Weyand, I. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100654 · Cited by 284
Colour As a Signal for Entraining the Mammalian Circadian Clock
Walmsley, L., Hanna, L., Mouland, J., Martial, F., West, A., Smedley, A. R., Bechtold, D. A., Webb, A. R., Lucas, R. J., & Brown, T. M. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002127 · Cited by 211
“This distinction was absent in mice lacking cone phototransduction (Cnga3, [29,30]; Fig 5B; 6 ± 9 min; paired t test, p = 0.”
BackgroundThiadens, A. A. H. J., Somervuo, V., van den Born, L. I., Roosing, S., van Schooneveld, M. J., Kuijpers, R. W. A. M., van Moll-Ramirez, N., Cremers, F. P. M., Hoyng, C. B., & Klaver, C. C. W. (2010) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-5680 · Cited by 148
Metadata
- Authors
- Biel, M., Seeliger, M., Pfeifer, A., Kohler, K., Gerstner, A., Ludwig, A., Jaissle, G., Fauser, S., Zrenner, E., & Hofmann, F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-06-22
- Volume
- 96
- Issue
- 13
- Pages
- 7553-7557
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2119719550
- Cited by
- 279
- References
- 0
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3. https://app.cochat.ai/papers/10.1073/pnas.96.13.7553
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- Biel, M., Seeliger, M., Pfeifer, A., Kohler, K., Gerstner, A., Ludwig, A., Jaissle, G., Fauser, S., Zrenner, E., & Hofmann, F. (1999). Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.13.7553
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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