Colour As a Signal for Entraining the Mammalian Circadian Clock
Open accessAbstract
Twilight is characterised by changes in both quantity ("irradiance") and quality ("colour") of light. Animals use the variation in irradiance to adjust their internal circadian clocks, aligning their behaviour and physiology with the solar cycle. However, it is currently unknown whether changes in colour also contribute to this entrainment process. Using environmental measurements, we show here that mammalian blue-yellow colour discrimination provides a more reliable method of tracking twilight progression than simply measuring irradiance. We next use electrophysiological recordings to demonstrate that neurons in the mouse suprachiasmatic circadian clock display the cone-dependent spectral opponency required to make use of this information. Thus, our data show that some clock neurons are highly sensitive to changes in spectral composition occurring over twilight and that this input dictates their response to changes in irradiance. Finally, using mice housed under photoperiods with simulated dawn/dusk transitions, we confirm that spectral changes occurring during twilight are required for appropriate circadian alignment under natural conditions. Together, these data reveal a new sensory mechanism for telling time of day that would be available to any mammalian species capable of chromatic vision.
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Color signals, particularly the blue-yellow color discrimination, entrain the inner clock.
“Beside the influence of irradiance it was also shown that color signals, particularly the blue‐yellow color discrimination, entrain the inner clock 76.”
From The inner clock-Blue light sets the human rhythm (2019) · cites this paper as [76]
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- Authors
- Walmsley, L., Hanna, L., Mouland, J., Martial, F., West, A., Smedley, A. R., Bechtold, D. A., Webb, A. R., Lucas, R. J., & Brown, T. M.
- Affiliations
- University of Manchester (GB)
- Corresponding author
- Lucas, Robert J.
- Brown, Timothy M.
- ORCID
- Venue
- PLOS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-04-17
- Volume
- 13
- Issue
- 4
- Pages
- e1002127
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- PMC
- PMC4401556
- OpenAlex
- W2052034821
- Cited by
- 211
- References
- 50
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 24 · 2023: 18 · 2022: 13 · 2021: 34 · 2020: 29 · 2019: 22 · 2018: 14 · 2017: 18 · 2016: 18 · 2015: 6
- FWCI
- 10.35
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS Biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Research Explorer (The University of Manchester) (submittedVersion, other-oa)
- Funders
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council (BB/J017744/1, BB/I018654/1, BB/I017836/1, 1200479)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- circadian entrainment, twilight, light color, suprachiasmatic nucleus, cone photoreceptors, irradiance, color vision, photoperiod, clock neurons
- MeSH terms
- Melanopsin, Animals, Color, Photic Stimulation, Suprachiasmatic Nucleus, Rod Opsins, Mice, Knockout, Mice, Circadian Clocks
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