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The genetic mediation of individual differences in sensitivity to pain and its inhibition

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Mogil, Jeffrey S.·1999·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.96.14.7744
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Abstract

The underlying bases of the considerable interindividual variability in pain-related traits are starting to be revealed. Although the relative importance of genes versus experience in human pain perception remains unclear, rodent populations display large and heritable differences in both nociceptive and analgesic sensitivity. The identification and characterization of particularly divergent populations provides a powerful initial step in the genetic analysis of pain, because these models can be exploited to identify genes contributing to the behavior-level variability. Ultimately, DNA sequence differences representing the differential alleles at pain-relevant genes can be identified. Thus, by using a combination of “top-down” and “bottom-up” strategies, we are now able to genetically dissect even complex biological traits like pain. The present review summarizes the current progress toward these ends in both humans and rodents.

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Metadata

Authors
Mogil, J. S.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1999-07-06
Volume
96
Issue
14
Pages
7744-7751
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.96.14.7744
OpenAlex
W2000518252
Cited by
434
References
4
FWCI
9.51
Type
journal article
Language
en
Open access
green

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Mogil, J. S. (1999). The genetic mediation of individual differences in sensitivity to pain and its inhibition. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.14.7744

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