The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils
Open accessAbstract
IL-18 is a proinflammatory cytokine that plays an important role in natural killer cell activation and T helper 1 (Th1) cell responses. Mast cells and basophils are major inducers and effectors of allergic inflammation. Here we show that basophils and mast cells derived by culture of bone marrow cells with IL-3 for 10 days express IL-18Rα chain and that basophils produce large amounts of IL-4 and IL-13 in response to stimulation with IL-3 and IL-18. Injection of IL-12 and IL-18 inhibits IgE production in helminth-infected wild-type mice and abolishes the capacity of their basophils to produce IL-4 and IL-13 in response to stimulation either with IL-3 and IL-18 or with FcɛR cross-linkage. By contrast, this combination of cytokines actually increases IgE levels in helminth-infected IFN-γ−/−mice and enhances IL-4 and IL-13 production by their basophils. Furthermore, injection of IL-18 alone enhances basophil production of IL-4 and histamine both in wild-type and IFN-γ−/−mice. Thus, IL-18 has the potential to stimulate basophils but, when given with IL-12, exhibits an antiallergic action in vivo.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cloning of a new cytokine that induces IFN-γ production by T cells
Okamura, H., Tsutsui, H., Komatsu, T., Yutsudo, M., Hakura, A., Tanimoto, T., Torigoe, K., Okura, T., Nukada, Y., Hattori, K., et al. (1995) · Nature · doi:10.1038/378088a0 · Cited by 2,600
Self-citationMast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores
Plaut, M., Pierce, J. H., Watson, C. J., Hanley-Hyde, J., Nordan, R. P., & Paul, W. E. (1989) · Nature · doi:10.1038/339064a0 · Cited by 1,170
Self-citationAnderson, P. C. (1999) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.281.24.2351 · Cited by 1,006
IL-18: A TH1 -inducing, proinflammatory cytokine and new member of the IL-1 family
Dinarello, C. A. (1999) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(99)70518-x · Cited by 819
Yoshimoto, T., Takeda, K., Tanaka, T., Ohkusu, K., Kashiwamura, S., Okamura, H., Akira, S., & Nakanishi, K. (1998) · PubMed · Cited by 770
Self-citationRobinson, D., Shibuya, K., Mui, A., Zonin, F., Murphy, E., Sana, T., Hartley, S. B., Menon, S., Kastelein, R., Bazan, F., et al. (1997) · Immunity · doi:10.1016/s1074-7613(00)80378-7 · Cited by 720
Yoshimoto, T., Takeda, K., Tanaka, T., Ohkusu, K., Kashiwamura, S.-I., Okamura, H., Akira, S., & Nakanishi, K. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.7.3400 · Cited by 675
Self-citationInduction of human IgE synthesis in B cells by mast cells and basophils
Gauchat, J.-F., Henchoz, S., Mazzei, G., Aubry, J.-P., Brunner, T., Blasey, H., Life, P., Talabot, D., Flores-Romo, L., Thompson, J., et al. (1993) · Nature · doi:10.1038/365340a0 · Cited by 656
Ushio, S., Namba, M., Okura, T., Hattori, K., Nukada, Y., Akita, K., Tanabe, F., Konishi, K., Micallef, M., Fujii, M., et al. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.11.4274 · Cited by 624
Self-citationBurd, P. R., Rogers, H. W., Gordon, J. R., Martin, C. A., Jayaraman, S., Wilson, S. D., Dvorak, A. M., Galli, S. J., & Dorf, M. E. (1989) · The Journal of experimental medicine · doi:10.1084/jem.170.1.245 · Cited by 539
Cited by
Dextran Sulfate Sodium (DSS)‐Induced Colitis in Mice
Chassaing, B., Aitken, J. D., Malleshappa, M., & Vijay‐Kumar, M. (2014) · Current Protocols in Immunology · doi:10.1002/0471142735.im1525s104 · Cited by 2,090
Interleukin-18 Regulates Both Th1 and Th2 Responses
Nakanishi, K., Yoshimoto, T., Tsutsui, H., & Okamura, H. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.423 · Cited by 1,315
Self-citationHurst, S. D., Muchamuel, T., Gorman, D. M., Gilbert, J. M., Clifford, T., Kwan, S., Menon, S., Seymour, B., Jackson, C., Kung, T. T., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.1.443 · Cited by 619
Type 2 Immunity Reflects Orchestrated Recruitment of Cells Committed to IL-4 Production
Voehringer, D., Shinkai, K., & Locksley, R. M. (2004) · Immunity · doi:10.1016/s1074-7613(04)00026-3 · Cited by 425
Histamine, histamine receptors and their role in immune pathology
Jutel, M., Akdis, M., & Akdis, C. A. (2009) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2009.03374.x · Cited by 329
Metadata
- Authors
- Yoshimoto, T., Tsutsui, H., Tominaga, K., Hoshino, K., Okamura, H., Akira, S., Paul, W. E., & Nakanishi, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-11-23
- Volume
- 96
- Issue
- 24
- Pages
- 13962-13966
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2161937009
- Cited by
- 438
- References
- 33
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils. https://app.cochat.ai/papers/10.1073/pnas.96.24.13962
- The paper
- Yoshimoto, T., Tsutsui, H., Tominaga, K., Hoshino, K., Okamura, H., Akira, S., Paul, W. E., & Nakanishi, K. (1999). IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.24.13962
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
