The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.
Histamine, histamine receptors and their role in immune pathology
Abstract
Summary: The important roles of histamine in body physiology and various pathologic events have been well established, whereas new and exciting findings are still being uncovered. Histamine is not only the major mediator of the acute inflammatory and immediate hypersensitivity responses, but has also been demonstrated to affect chronic inflammation and regulate several essential events in the immune response. The diverse effects of histamine on immune regulation are due to the differential expression and regulation of four histamine receptors (HR) and their distinct intracellular signals. Differences in the affinities of these receptors are highly decisive on the biological effects of histamine and agents that target HRs. In particular, the discovery of reciprocal regulation of T cell activity by H1 and H2 receptor activation indicating histamine‐cytokine cross‐talk, as well as the characterization of the fourth histamine receptor (HR4) and its expression on numerous immune and inflammatory cells have prompted a re‐evaluation of the actions of histamine. This accounts for a new potential for HR antagonists and agonists in targeting various immunopathologic conditions.
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Cites
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Self-citationThe role of histamine and the tuberomamillary nucleus in the nervous system
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Cited by
Eifan, A. O., & Durham, S. R. (2016) · Clinical & Experimental Allergy · doi:10.1111/cea.12780 · Cited by 379
Regulation of the immune response and inflammation by histamine and histamine receptors
O’Mahony, L., Akdis, M., & Akdis, C. A. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.06.051 · Cited by 313
Self-citationVo, T.-S., Ryu, B., & Kim, S.-K. (2013) · Journal of Functional Foods · doi:10.1016/j.jff.2013.05.001 · Cited by 209
The CCN family: A new class of inflammation modulators?
Kular, L., Pakradouni, J., Kitabgi, P., Laurent, M., & Martinerie, C. (2011) · Biochimie · doi:10.1016/j.biochi.2010.11.010 · Cited by 183
Pathophysiology of Allergic and Nonallergic Rhinitis
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Metadata
- Authors
- Jutel, M., Akdis, M., & Akdis, C. A.
- Venue
- Clinical & Experimental Allergy
- Publisher
- Wiley
- Published
- 2009-11-13
- Volume
- 39
- Issue
- 12
- Pages
- 1786-1800
- ISSN
- 0954-7894 (ISSN-L)
- 1365-2222
- OpenAlex
- W2020342012
- Cited by
- 329
- References
- 133
- FWCI
- 7.76
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
