The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion
Open accessAbstract
Apoptotic and necrotic cell death are well characterized and are influenced by intracellular ATP levels. Poly(ADP-ribose) polymerase (PARP), a nuclear enzyme activated by DNA strand breaks, physiologically participates in DNA repair. Overactivation of PARP after cellular insults can lead to cell death caused by depletion of the enzyme’s substrate β-nicotinamide adenine dinucleotide and of ATP. In this study, we have differentially elicited apoptosis or necrosis in mouse fibroblasts. Fibroblasts from PARP-deficient (PARP −/− ) mice are protected from necrotic cell death and ATP depletion but not from apoptotic death. These findings, together with cell death patterns in PARP −/− animals receiving other types of insults, indicate that PARP activation is an active trigger of necrosis, whereas other mechanisms mediate apoptosis.
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Pyroptosis: Mechanisms and Diseases
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Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor
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Metadata
- Authors
- Ha, H. C., & Snyder, S. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-11-23
- Volume
- 96
- Issue
- 24
- Pages
- 13978-13982
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2061298493
- Cited by
- 907
- References
- 41
- FWCI
- 10.66
- Type
- journal article
- Language
- en
- Open access
- green
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- Ha, H. C., & Snyder, S. H. (1999). Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.24.13978
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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