The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
The relationship between the volume of antimicrobial consumption in human communities and the frequency of resistance
Open accessAbstract
The threat to human health posed by antibiotic resistance is of growing concern. Many commensal and pathogenic organisms have developed resistance to well established and newer antibiotics. The major selection pressure driving changes in the frequency of antibiotic resistance is the volume of drug use. However, establishing a quantitative relationship between the frequency of resistance and volume of drug use has proved difficult. Using population genetic methods and epidemiological observations, we report an analysis of the influence of the selective pressure imposed by the volume of drug use on temporal changes in resistance. Analytical expressions are derived to delineate key relationships between resistance and drug consumption. The analyses indicate that the time scale for emergence of resistance under a constant selective pressure is typically much shorter than the decay time after cessation or decline in the volume of drug use and that significant reductions in resistance require equally significant reductions in drug consumption. These results highlight the need for early intervention once resistance is detected.
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Cites
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Self-citationThe crisis in antibiotic resistance
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Cited by
Outpatient antibiotic use in Europe and association with resistance: a cross-national database study
Goossens, H., Ferech, M., Vander Stichele, R., & Elseviers, M. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17907-0 · Cited by 3,359
Call of the wild: antibiotic resistance genes in natural environments
Allen, H. K., Donato, J., Wang, H. H., Cloud-Hansen, K. A., Davies, J., & Handelsman, J. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2312 · Cited by 2,361
Probiotic bacteria: safety, functional and technological properties
Saarela, M., Mogensen, G., Fondén, R., Mättö, J., & Mattila-Sandholm, T. (2000) · Journal of Biotechnology · doi:10.1016/s0168-1656(00)00375-8 · Cited by 1,202
The biological cost of antibiotic resistance
Andersson, D. I., & Levin, B. R. (1999) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(99)00005-3 · Cited by 867
The fitness costs of antibiotic resistance mutations
Melnyk, A. H., Wong, A., & Kassen, R. (2015) · Evolutionary Applications · doi:10.1111/eva.12196 · Cited by 689
Metadata
- Authors
- Austin, D. J., Kristinsson, K. G., & Anderson, R. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-02-02
- Volume
- 96
- Issue
- 3
- Pages
- 1152-1156
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2001700040
- Cited by
- 784
- References
- 30
- FWCI
- 37.23
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
