The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Blood-borne tissue factor: Another view of thrombosis
Open accessAbstract
Arterial thrombosis is considered to arise from the interaction of tissue factor (TF) in the vascular wall with platelets and coagulation factors in circulating blood. According to this paradigm, coagulation is initiated after a vessel is damaged and blood is exposed to vessel-wall TF. We have examined thrombus formation on pig arterial media (which contains no stainable TF) and on collagen-coated glass slides (which are devoid of TF) exposed to flowing native human blood. In both systems the thrombi that formed during a 5-min perfusion stained intensely for TF, much of which was not associated with cells. Antibodies against TF caused ≈70% reduction in the amount of thrombus formed on the pig arterial media and also reduced thrombi on the collagen-coated glass slides. TF deposited on the slides was active, as there was abundant fibrin in the thrombi. Factor VII ai , a potent inhibitor of TF, essentially abolished fibrin production and markedly reduced the mass of the thrombi. Immunoelectron microscopy revealed TF-positive membrane vesicles that we frequently observed in large clusters near the surface of platelets. TF, measured by factor X a formation, was extracted from whole blood and plasma of healthy subjects. By using immunostaining, TF-containing neutrophils and monocytes were identified in peripheral blood; our data raise the possibility that leukocytes are the main source of blood TF. We suggest that blood-borne TF is inherently thrombogenic and may be involved in thrombus propagation at the site of vascular injury.
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Cites
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Self-citationWhole Blood Tissue Factor Procoagulant Activity Is Elevated in Patients With Sickle Cell Disease
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Expression of tissue factor procoagulant activity: regulation by cytosolic calcium.
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Low molecular weight, non-peptide fibrinogen receptor antagonists
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Design and Synthesis of Potent and Highly Selective Thrombin Inhibitors
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Self-citationAssociation of tissue factor activity with the surface of cultured cells.
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Self-citationIncreased plasma tissue factor levels in acute myocardial infarction
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Thrombosis as an intravascular effector of innate immunity
Engelmann, B., & Massberg, S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3345 · Cited by 1,989
Mechanisms of Thrombus Formation
Furie, B., & Furie, B. C. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0801082 · Cited by 1,926
A Cell-based Model of Hemostasis
Monroe, D., & Hoffman, M. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1615947 · Cited by 1,542
Membrane Microparticles: Two Sides of the Coin
Hugel, B., Martínez, M. C., Kunzelmann, C., & Freyssinet, J.-M. (2005) · Physiology · doi:10.1152/physiol.00029.2004 · Cited by 698
Platelets in inflammation and thrombosis
Wagner, D. D., & Burger, P. C. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000095974.95122.ec · Cited by 570
Metadata
- Authors
- Giesen, P. L. A., Rauch, U., Bohrmann, B., Kling, D., Roqué, M., Fallon, J. T., Badimon, J. J., Himber, J., Riederer, M. A., & Nemerson, Y.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-03-02
- Volume
- 96
- Issue
- 5
- Pages
- 2311-2315
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2142649232
- Cited by
- 991
- References
- 15
- FWCI
- 16.79
- Type
- journal article
- Language
- en
- Open access
- green
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- Giesen, P. L. A., Rauch, U., Bohrmann, B., Kling, D., Roqué, M., Fallon, J. T., Badimon, J. J., Himber, J., Riederer, M. A., & Nemerson, Y. (1999). Blood-borne tissue factor: Another view of thrombosis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.5.2311
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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