Membrane Microparticles: Two Sides of the Coin
Abstract
Microparticles are plasma membrane-derived vesicles shed from stimulated cells, in the broad sense of the term. Their presence is interpreted by proximal or remote cells in fundamental physiological processes including intercellular communication, hemostasis, and immunity. On the other hand, variations of their number or characteristics are frequently observed in pathophysiological situations.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Actin-myosin interactions appear critical to formation of all four EV types, and phosphatidylserine translocation to the outer membrane is common to apoptotic bodies and microvesicles.
“For instance, actin-myosin interactions appear critical to the formation of all four types of EVs [66, 85, 100, 115].”
From Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies (2013) · cites this paper as [65]
Microvesicle formation involves phosphatidylserine translocation to the outer membrane leaflet and completion by actin-myosin cytoskeletal contraction.
“Membrane budding/vesicle formation is induced by translocation of phosphatidylserine to the outer-membrane leaflet [62, 65]. The budding process is completed through contraction of cytoskeletal structures by actin-myosin interactions [66, 67].”
From Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies (2013) · cites this paper as [65]
Cited by
Sorted by citations
Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles
Colombo, M., Raposo, G., & Théry, C. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122326 · Cited by 6,186 · see citing works
Akers, J. C., Gonda, D., Kim, R., Carter, B. S., & Chen, C. C. (2013) · Journal of Neuro-Oncology · doi:10.1007/s11060-013-1084-8 · Cited by 1,423 · see citing works
“Membrane budding/vesicle formation is induced by translocation of phosphatidylserine to the outer-membrane leaflet [62, 65].”
Turturici, G., Tinnirello, R., Sconzo, G., & Geraci, F. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00228.2013 · Cited by 483 · see citing works
Delivery of chemotherapeutic drugs in tumour cell-derived microparticles
Tang, K., Zhang, Y., Zhang, H., Xu, P., Liu, J., Ma, J., Lv, M., Li, D., Katirai, F., Shen, G.-X., et al. (2012) · Nature Communications · doi:10.1038/ncomms2282 · Cited by 453 · see citing works
Inhibition of the Multidrug Resistance P-Glycoprotein: Time for a Change of Strategy?
Callaghan, R., Luk, F., & Bebawy, M. (2014) · Drug Metabolism and Disposition · doi:10.1124/dmd.113.056176 · Cited by 453 · see citing works
Endothelial microparticles in diseases
Chironi, G. N., Boulanger, C. M., Simon, A., Dignat-George, F., Freyssinet, J.-M., & Tedgui, A. (2009) · Cell and Tissue Research · doi:10.1007/s00441-008-0710-9 · Cited by 420 · see citing works
Self-citationExtracellular vesicles: A bright star of nanomedicine
Wu, P., Zhang, B., Ocansey, D. K. W., Xu, W., & Qian, H. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2020.120467 · Cited by 368 · see citing works
Ticket to a bubble ride: Cargo sorting into exosomes and extracellular vesicles
Anand, S., Samuel, M., Kumar, S., & Mathivanan, S. (2019) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2019.02.005 · Cited by 284 · see citing works
Extracellular vesicles: pathogenetic, diagnostic and therapeutic value in traumatic brain injury
Mondello, S., Thelin, E. P., Shaw, G., Salzet, M., Visalli, C., Cizkova, D., Kobeissy, F., & Buki, A. (2018) · Expert Review of Proteomics · doi:10.1080/14789450.2018.1464914 · Cited by 53 · see citing works
Tadokoro, R., Murai, H., Sakai, K.-I., Okui, T., Yokota, Y., & Takahashi, Y. (2016) · Scientific Reports · doi:10.1038/srep38277 · Cited by 38 · see citing works
- Authors
- Hugel, B., Martínez, M. C., Kunzelmann, C., & Freyssinet, J.-M.
- Affiliations
- Inserm (FR)
- ORCID
- Martínez, M. Carmen
- Venue
- Physiology
- Publisher
- American Physiological Society
- Published
- 2005-02
- Volume
- 20
- Issue
- 1
- Pages
- 22-27
- ISSN
- 0886-1714 (ISSN-L)
- 1548-9213
- 1548-9221
- OpenAlex
- W2162159732
- Cited by
- 698
- References
- 0
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 21 · 2023: 26 · 2022: 34 · 2021: 32 · 2020: 33 · 2019: 35 · 2018: 46 · 2017: 51 · 2016: 36 · 2015: 29 · 2014: 41 · 2013: 50 · 2012: 42
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Keywords
- membrane microparticles, intercellular communication, hemostasis, immunity, pathophysiology, cell shedding
- MeSH terms
- Animals, Blood Coagulation, Cell Communication, Cell Membrane, Cell Physiological Phenomena, Humans, Immunity, Particle Size, Protein Transport
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
